Antibacterial effects of iron oxide (Fe3O4) nanoparticles: distinguishing concentration-dependent effects with different bacterial cells growth and membrane-associated mechanisms

Gabrielyan, Lilit; Hovhannisyan, A.; Gevorgyan, Vladimir; Ananyan, Michail; Trchоunian, Armen

doi:10.1007/s00253-019-09653-x

Cited by 114 publications

(90 citation statements)

References 41 publications

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“…In this case, the particles are able to destroy the cells inside the biofilm. It has been shown that iron-oxide NPs were able to reduce biofilm growth by S. aureus , E. coli , P. aeruginosa [ 88 ], S. epidermidis [ 38 ], and Enterococcus hirae [ 89 ].…”

Section: Effects Of Metal Oxide Nps On Plankton Cells and Biofilmmentioning

confidence: 99%

Metal Oxide Nanoparticles Against Bacterial Biofilms: Perspectives and Limitations

2020

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At present, there is an urgent need in medicine and industry to develop new approaches to eliminate bacterial biofilms. Considering the low efficiency of classical approaches to biofilm eradication and the growing problem of antibiotic resistance, the introduction of nanomaterials may be a promising solution. Outstanding antimicrobial properties have been demonstrated by nanoparticles (NPs) of metal oxides and their nanocomposites. The review presents a comparative analysis of antibiofilm properties of various metal oxide NPs (primarily, CuO, Fe3O4, TiO2, ZnO, MgO, and Al2O3 NPs) and nanocomposites, as well as mechanisms of their effect on plankton bacteria cells and biofilms. The potential mutagenicity of metal oxide NPs and safety problems of their wide application are also discussed.

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Section: Effects Of Metal Oxide Nps On Plankton Cells and Biofilmmentioning

confidence: 99%

Metal Oxide Nanoparticles Against Bacterial Biofilms: Perspectives and Limitations

2020

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“…And the point of attack depends on the particle location upon excitation. Such oxidative reactions can affect cell integrity and the chemical arrangement of surface structures and are the main mechanisms of their photocatalytic antibacterial activities [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Study on Photocatalytic Antibacterial and Sustained-Release Properties of Cellulose/TiO₂/β-CD Composite Hydrogel

Zhang

Zhu

et al. 2019

Journal of Nanomaterials

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A novel cellulose/TiO2/β-CD hydrogel with high photocatalytic antibacterial activity and sustained release of drug was prepared. TiO2 sol with a diameter of about 9 nm in this hydrogel was the photoantibacterial agent. β-CD can significantly enhance photoantibacterial activity and the sustained-release effect of this hydrogel. The structure and property of this hydrogel composite were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Escherichia coli and Staphylococcus aureus were selected as model bacteria to evaluate the antibacterial activity of the composite hydrogel under natural light irradiation and darkness, respectively. The in vitro release experiment used curcumin as a model drug in PBS buffer solution. The influence of β-CD on the antibacterial activity and sustained-release effect of the composite hydrogel was investigated. The results showed that the hydrogel composite presented a good photoantibacterial property, while the antibacterial activity can be neglected under the condition of no light. The complete release of curcumin from the composite was achieved after 120 h. Therefore, the hydrogel system has the characteristics of low cost and high effect, which could be used for an antibacterial sustained-release material.

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“…Wang et al also demonstrated that ZnO/GO composites have a much stronger ability to kill bacteria at low concentrations, and at the low concentrations the viability of HeLa cells was not affected. Gram‐negative Escherichia coli BW 25 113 and Gram‐positive Enterococcus ATCC 9790 biofilms treated with Fe 3 O 4 nanoparticles exhibited a dose‐dependent decrease in bacteria viability …”

Section: Factors Influencing the Antibiofilm Properties Of Nanoparticlesmentioning

confidence: 99%

Nanoparticles for the Treatment of Oral Biofilms: Current State, Mechanisms, Influencing Factors, and Prospects

Wang

Yuan

et al. 2019

Adv Healthcare Materials

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Due to their excellent size, designability, and outstanding targeted antibacterial effects, nanoparticles have become a potential option for controlling oral biofilm‐related infections. However, the formation of an oral biofilm is a dynamic process, and factors affecting the performance of antibiofilm treatments are complex. As such, when examining the existing literature on the antibiofilm effects of nanoparticles, attention should be paid to the specific mechanisms of action at different stages of oral biofilm formation, as well as relevant influencing factors, in order to achieve an objective and comprehensive evaluation. This review is intended to detail the antibacterial mechanisms of nanoparticles during the four stages of the formation of oral biofilms: 1) acquired film formation; 2) bacterial adhesion; 3) early biofilm development; and 4) biofilm maturation. In addition, factors influencing the antibiofilm properties of nanoparticles are summarized from the aspects of nanoparticles themselves, biofilm models, and host factors. The limitations of current research and possible trends for future research are also discussed. In summary, nanoparticles are a promising antioral biofilm strategy. It is hoped that this review can serve as a reference and inspire ideas for further research on the application of nanoparticles for effectively targeting and treating oral biofilms.

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Antibacterial effects of iron oxide (Fe3O4) nanoparticles: distinguishing concentration-dependent effects with different bacterial cells growth and membrane-associated mechanisms

Cited by 114 publications

References 41 publications

Metal Oxide Nanoparticles Against Bacterial Biofilms: Perspectives and Limitations

Metal Oxide Nanoparticles Against Bacterial Biofilms: Perspectives and Limitations

Study on Photocatalytic Antibacterial and Sustained-Release Properties of Cellulose/TiO₂/β-CD Composite Hydrogel

Nanoparticles for the Treatment of Oral Biofilms: Current State, Mechanisms, Influencing Factors, and Prospects

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Antibacterial effects of iron oxide (Fe3O4) nanoparticles: distinguishing concentration-dependent effects with different bacterial cells growth and membrane-associated mechanisms

Cited by 114 publications

References 41 publications

Metal Oxide Nanoparticles Against Bacterial Biofilms: Perspectives and Limitations

Metal Oxide Nanoparticles Against Bacterial Biofilms: Perspectives and Limitations

Study on Photocatalytic Antibacterial and Sustained-Release Properties of Cellulose/TiO2/β-CD Composite Hydrogel

Nanoparticles for the Treatment of Oral Biofilms: Current State, Mechanisms, Influencing Factors, and Prospects

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Study on Photocatalytic Antibacterial and Sustained-Release Properties of Cellulose/TiO₂/β-CD Composite Hydrogel