Antibacterial Effects of Ethanol and Acetone Extract of Plantago major L. on Gram Positive and Gram Negative Bacteria

Metiner, Kemal; Özkan, Oktay; Srivastava, A. K.

doi:10.9775/kvfd.2011.5824

Cited by 11 publications

(4 citation statements)

References 10 publications

(6 reference statements)

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“…Several authors have mentioned P. major as an antibacterial, antifungal, and antiviral compound. A study in Turkey demonstrated that the acetone extract of P. major has antimicrobial properties against nine species of bacteria, and also, an ethyl alcohol extract has bactericidal activity against E. coli and Bacillus cereus [24]. Fungicidal activity of P. major against growth, metabolic activity, and biofilm formation of Candida albicans was proved in a study by Shirley et al [25].…”

Section: Discussionmentioning

confidence: 98%

Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study

Keshavarzi

Montaseri

Akrami

et al. 2022

International Journal of Clinical Practice

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Background. Great plantain (Plantago major L. or P.major) is a medicinal plant that is available all around the world. The whole plant has several bioactive compounds including terpenoids, flavonoids, phenolic compounds, alkaloids, fatty acids, iridoid glycosides, polysaccharides, and vitamins. Scientific studies have recognized several medical benefits like wound healing, anti-inflammatory, antimicrobial, antiulcerative, and antioxidative agents. The wound-healing capacity of this plant has been investigated under in vivo and ex vivo conditions. In the current study, we aim to compare the therapeutic effect of the P.major extract with 1% sulfadiazine on the healing of second-degree burn wounds. Method. Second-degree burn victims were included in our study. The investigation and control group, respectively, received P. major ointment 10% and silver sulfadiazine ointment 1%. The bacterial culture from the wound site was taken on days 3, 7, 10, 13, and last day of hospitalization. Patients’ subjective complaints were obtained through the visual analog scale (VAS). All patients were treated and evaluated in the hospital. Result. Among the 15 patients, 11 were male, and the mean age was 33.3 years. The average complete healing duration was 11.73 vs. 13 days in the P. major and control group, respectively ( P = 0.166 ). On the third day, infection control was similar between the two groups, and on the seventh day, all bacterial cultures were negative. Although there was a significant reduction in pain scores during the recovery time, no significant differences in pain reduction were noted between the two groups ( P = 0.849 ). Conclusion. We showed that P.major ointment is a safe and suitable herbal compound in the treatment of second-degree burn wounds that not only has wound-healing properties but also is an analgesic and antimicrobial compound.

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Section: Discussionmentioning

confidence: 98%

Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study

Keshavarzi

Montaseri

Akrami

et al. 2022

International Journal of Clinical Practice

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“…Similarly, the highest antimicrobial activity of Rumex acetosa L. against all strains had a significant effect against Salmonella enteritidis compared to the other extracts, while the highest antimicrobial activity of Urtica dioca L. was recorded against L. innocua, with each plant demonstrating relatively lower but fairly significant activity against the other strains. The antimicrobial properties of Rumex acetosa L. against staphylococci and Gramnegative bacteria, including Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, as well as fungi Candida spp., or Trichophyton mentagrophytes, have been reported using the agar dilution method [35]. Urtica dioca L. has also demonstrated antimicrobial activity against Acinetobacter calcoaceticus, Bacillus cereus, Bacillus spizizenii, Micrococcus spp., Vibrio parahaemolyticus, Escherichia coli, Bacillus subtilis, methicillin-resistant Staphylococcus aureus, Klebsiella pneumonia, and Salmonella paratyphi B [36,37].…”

Section: Discussionmentioning

confidence: 99%

New Insights into Bioactive Compounds of Wild-Growing Medicinal Plants

Salem,

Szwajkowska-Michałek,

Przybylska-Balcerek

et al. 2023

Applied Sciences

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Plants contain bioactive substances and secondary metabolites that have a variety of functions, including antibacterial, antioxidant, anti-inflammatory, and anticancer activities. In this study, the content of bioactive compounds in five medicinal plants was determined, i.e., Plantago major L., Armoracia rusticana, Hypericum perforatum L., Rumex acetosa L., and Urtica dioica L., from 38 locations. Additionally, the antimicrobial effect of extracts of bioactive compounds from the above-mentioned plants was checked. The experiment used an original method of extracting bioactive compounds. Purpose of the research: the assessment of antimicrobial activity and chemical characterization of extracts obtained using our own method of isolating bioactive compounds from green parts of medical plants in Poland. Based on the research, the presence of bioactive compounds, i.e., phenolic acids and flavonoids, was found in the tested plant extracts. The results of this study suggest that the geographic parameters of the locations where these plants grow have different effects on their biochemical composition and biological activity. The results showed that all tested plants had significant antibacterial activities. Rumex acetose L. showed the highest antimicrobial activity against Escherichia coli and Salmonella enteritidis. These studies supplement the existing literature on the subject with information about the antimicrobial properties of the tested plant extracts that can be used in herbal medicine. The results have significant implications for the pharmaceutical, nutraceutical, and cosmetic sectors, establishing a foundation for future research in this area.

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“…Acetone extract performed well when used against Bacillus cereus (3.562 mg/mL), while performing poorly when used against B. subtilis, P. mirabilis, P. aeruginosa, and S. epidermidis (28.500 mg/mL) [65]. However, investigations by Metiner et al (2012) showed that all the bacteria utilized in the study-aside from E. coli and B. cereus-are resistant to the ethanol extract of Plantago major's roots [66]. At the same time, two strains of Porphyromonas gingivalis and Fusobacterium nucleatum in vitro were inhibited by ethanol extracts of the root of Plantago major at doses of 75% and 100%.…”

Section: Antimicrobial Effectsmentioning

confidence: 99%

Antimicrobial and Other Biomedical Properties of Extracts from Plantago major, Plantaginaceae

Zhakipbekov,

Turgumbayeva,

Issayeva

et al. 2023

Pharmaceuticals

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Since ancient times, many scientists and doctors have used various herbs to treat diseases. Conventional drugs often have side effects, and pathogens are becoming resistant to these types of drugs. In such circumstances, the study of traditional medicinal plants is an effective and logical strategy for finding new herbal medicines. One such herb is Plantago major, a perennial plant in the Plantaginaceae family that is found throughout the world. The Plantago major plant has been used as a medicine for the treatment of various diseases. Studies have shown that plant extracts of Plantago major exhibit antimicrobial, antiviral, and anti-inflammatory effects, and have wound-healing properties. This review collects and presents the results of various studies of Plantago major plant extracts with antimicrobial, antiviral, antifungal, anti-inflammatory, and wound-healing properties, which demonstrate a wide range of therapeutic possibilities of Plantago major plant extracts and have a huge potential for use as a medicinal raw material.

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Antibacterial Effects of Ethanol and Acetone Extract of Plantago major L. on Gram Positive and Gram Negative Bacteria

Cited by 11 publications

References 10 publications

Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study

Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study

New Insights into Bioactive Compounds of Wild-Growing Medicinal Plants

Antimicrobial and Other Biomedical Properties of Extracts from Plantago major, Plantaginaceae

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