Antibacterial effect of titanium dioxide-doped phosphate glass microspheres filled total-etch dental adhesive on S. mutans biofilm

Antibacterial and Antibiofilm Efficacy of Copper-Doped Phosphate Glass on Pathogenic Bacteria

“…Copper-doped phosphate glass (CDPG), having 50 P 2 O 5 , 30 CaO, 10 Na 2 O, and 10 CuO, was prepared using the melt quenching process [ 15 , 16 ]; the number indicates the mol% of each component. The raw materials used for the glass preparation are phosphorus pentoxide, calcium hydrogen phosphate, sodium dihydrogen phosphate, and copper oxide.…”

“…They are degradable and the degradation can be effortlessly controlled by changing the glass chemistry. They can be modified with various metallic oxides that could induce antibacterial [ 14 , 15 ] or remineralizing actions [ 16 ]. Examples of these oxides include copper oxide [ 14 ], titanium dioxide [ 15 ], and gallium oxide [ 17 ].…”

“…They can be modified with various metallic oxides that could induce antibacterial [ 14 , 15 ] or remineralizing actions [ 16 ]. Examples of these oxides include copper oxide [ 14 ], titanium dioxide [ 15 ], and gallium oxide [ 17 ]. They can also be prepared in a variety of forms as a powder [ 18 ], microspheres [ 15 ], and fibers [ 19 ] to modulate their therapeutic potential.…”

“…Examples of these oxides include copper oxide [ 14 ], titanium dioxide [ 15 ], and gallium oxide [ 17 ]. They can also be prepared in a variety of forms as a powder [ 18 ], microspheres [ 15 ], and fibers [ 19 ] to modulate their therapeutic potential. Copper-doped phosphate glasses, for example, are effective as an antibacterial agent against Gram-positive cariogenic cocci ( Streptococcus mutans ), Gram-negative, rod-shaped, opportunistic multidrug-resistant bacteria Pseudomonas aeruginosa [ 18 ], and Gram-positive skin-related Staphylococcus epidermidis [ 14 ].…”

“…Copper-doped phosphate glasses, for example, are effective as an antibacterial agent against Gram-positive cariogenic cocci ( Streptococcus mutans ), Gram-negative, rod-shaped, opportunistic multidrug-resistant bacteria Pseudomonas aeruginosa [ 18 ], and Gram-positive skin-related Staphylococcus epidermidis [ 14 ]. Titanium-doped phosphate glasses have also proven to be biocompatible [ 20 , 21 ] with a promising antibacterial action against S. mutans when they were incorporated into total-etch dental adhesives [ 15 ]. Furthermore, copper-doped mesoporous glass nanospheres modified experimental dental composites could be a promising path for future investigations of antibacterial properties and ion release [ 22 ].…”