Antibacterial effect of plant extracts againstHelicobacter pylori

Abstract

The aim of this work was to evaluate the antibacterial effect of plant extracts as alternative and[sol ]or as active agents supporting antibiotics for treating Helicobacter pylori infection. The effect of either, ethanolic or aqueous extracts from 17 plant materials were studied against one H. pylori standard strain and 11 clinical isolates using a disc diffusion test and by evaluating the minimum inhibitory concentration (MIC) on solid media. An inhibitory activity against H. pylori strains was recorded in a large percentage of tested plants. MIC values of ethanolic extracts were from two to four concentration steps lower than the aqueous ones. In particular, ethanolic extracts of Cuminum cyminum L. and Propolis expressed MIC90 values of 0.075 mg/mL. The results show a significant in vitro effect of plant extracts against H. pylori that could be considered a valuable support in the treatment of the infection and may contribute to the development of new and safe agents for inclusion in anti-H. pylori regimens.

Medicinal plants in the treatment ofHelicobacter pyloriinfections

“…The resistant strains, when tested against this plant extract, expressed a similar profile to the other sensitive ones (Nostro et al, 2005).…”

<i>Cuminum cyminum </i>Linn (Apiaceae) extract attenuates MPTP-induced oxidative stress and behavioral impairments in mouse model of Parkinson’s disease

“…cyminum) Apiaceaeis is an annual herb widely used as a traditional medicine for the treatment of several disorders, such as toothaches, dyspepsia, diarrhea, epilepsy and jaundice [4]. Pharmacologically, C. cyminum has been reported to possess anti-diabetic, anti-bacterial, hepatoprotective, neuroprotective, anti-epileptic, hypolipidemic, anti-stress anti-oxidant and memory -enhancing properties [5][6][7].…”

Role of Natural Antioxidants in Gastritis

“…Recently, this plant has been shown to protect against gastric ulcers induced by non-steroidal anti-inflammatory drugs (NSAID) in rats (Trabadela et al, 2009). Numerous plant remedies have shown to be active against Helicobacter pylori infection, such as the oil extract of Chamomilla recutita (Shikov et al, 2008), the ethanolic extract of Cuminum cyminum L., Propolis (Nostro et al, 2005) as well as the methanolic extract of Alchornea triplinervia (Spreng.) Mull.…”