Antibacterial effect of copper composites against Xanthomonas euvesicatoria

Fan, Qiurong; Liao, Ying-Yu; Kunwar, Sanju; Silva, Susannah Da; Young, Mikhaeel; Santra, Swadeshmukul; Minsavage, Gerald V.; Freeman, Joshua H.; Jones, Jeffrey B.; Paret, Mathews L.

doi:10.1016/j.cropro.2020.105366

Cited by 23 publications

(7 citation statements)

References 28 publications

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“…The new copper composites coreshell copper (CS‐Cu), multivalent copper (MV‐Cu), and fixed quaternary ammonium copper (FQ‐Cu) have shown promising results as potential alternatives to commercially available micron‐sized copper bactericides (Strayer‐Scherer et al, 2018 ). Greenhouse assays using three copper‐based nanocomposites gave promising results, while MV‐Cu is the only copper composite with no phytotoxicity on plants under controlled conditions (Fan et al, 2021 ).…”

Section: Managementmentioning

confidence: 99%

A centenary for bacterial spot of tomato and pepper

Osdaghi

Jones

Sharma

et al. 2021

Molecular Plant Pathology

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Section: Managementmentioning

confidence: 99%

A centenary for bacterial spot of tomato and pepper

Osdaghi

Jones

Sharma

et al. 2021

Molecular Plant Pathology

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“…In this context, nanotechnology has shown great promise, consistently demonstrating that Cu at nanoscale can be significantly more effective than its bulk counterpart. 8,18,19 Therefore, it might be possible to reduce current Cu application rates owing to the improved efficacy of different Cu types. Hemp (Cannabis sativa L.) is a hardy crop from which, among many secondary metabolites, two topically pertinent compounds, the psychoactive compound tetrahydrocannabinol (THC) and the medically relevant related compound cannabidiol (CBD), collectively termed cannabinoids, are produced.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Nevertheless, when used intensively and persistently, Cu residues build up over time and can be detrimental to the environment. Associated consequences include Cu runoff into surface waters, development of Cu tolerance in pathogens, inhibition of the soil microbiome, and potential aquatic, phyto, and mammalian toxicities. − In addition to direct inhibitory effects as a pesticide, another mode by which Cu can protect plants from biotic and abiotic stresses is through systemic elicitation of the expression of disease resistance genes, such as polyphenol oxidase (PPO), pathogenicity related proteins (PRIs), and polyamine oxidase (PAO). , Additionally, modulation of metal reductase enzyme activities that could alter particulate Cu toxicity in plants have been reported . However, Cu is also known to modulate the production of a variety of critically important primary and secondary metabolites in different organisms, including suppression of siderophores but enhancement of indoleacetic acid production in bacteria , and inhibition of gluconate and butyrate in wheat .…”

Section: Introductionmentioning

confidence: 99%

“…There is, however, an increasing quest to improve the efficiency of Cu use to minimize its environmental footprint. In this context, nanotechnology has shown great promise, consistently demonstrating that Cu at nanoscale can be significantly more effective than its bulk counterpart. ,, Therefore, it might be possible to reduce current Cu application rates owing to the improved efficacy of different Cu types.…”

Section: Introductionmentioning

confidence: 99%

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Copper Stimulation of Tetrahydrocannabinol and Cannabidiol Production in Hemp (Cannabis sativa L.) Is Copper-Type, Dose, and Cultivar Dependent

Cahill,

Arsenault,

Bui

et al. 2024

J. Agric. Food Chem.

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Copper (Cu) is an element widely used as a pesticide for the control of plant diseases. Cu is also known to influence a range of plant secondary metabolisms. However, it is not known whether Cu influences the levels of the major metabolites in hemp (Cannabis sativa L.), tetrahydrocannabinol (THC) and cannabidiol (CBD). This study investigated the impact of Cu on the levels of these cannabinoids in two hemp cultivars, Wife and Merlot, under field conditions, as a function of harvest time (August− September), Cu type (nano, bulk, or ionic), and dose (50, 100, and 500 ppm). In Wife, Cu caused significant temporal increases in THC and CBD production during plant growth, reaching increases of 33% and 31% for THC and 51% and 16.5% for CBD by harvests 3 and 4, respectively. CuO nanoparticles at 50 and 100 ppm significantly increased THC and CBD levels, compared to the control, respectively, by 18% and 27% for THC and 19.9% and 33.6% for CBD. These nanospecific increases coincided with significantly more Cu in the inflorescences (buds) than in the control and bulk CuO treatments. Contrarily, no temporal induction of the cannabinoids by Cu was noticed in Merlot, suggesting a cultivar-specific response to Cu. However, overall, in Merlot, Cu ions, but not particulate Cu, induced THC and CBD levels by 27% and 36%, respectively, compared to the control. Collectively, our findings provide information with contrasting implications in the production of these cannabinoids, where, dependent on the cultivar, metabolite levels may rise above the 0.3% regulatory threshold for THC but to a more profitable level for CBD. Further investigations with a wider range of hemp cultivars, CuO nanoparticle (NP) doses, and harvest times would clarify the significance and broader implications of the findings.

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“…In recent years, a variety of nanomaterials have been developed/discovered to have antibacterial properties both in vitro and in planta against Cu-tolerant strains of X. perforans . This includes copper-core–shell silica, multivalent copper, and copper-fixed quat, − DNA-graphene oxide-Ag, , TiO 2 doped with Zn or Ag, MgO, ZnO, and Cu 2 O, , and Cu–Zn hybrid . Among these MgO is potentially a more sustainable treatment compared to Cu, and it is not on the list of the United State Environmental Protection Agency (EPA) Toxic Release Inventory (TRI) Program or in the Integrated Risk Information System (; ).…”

Section: Introductionmentioning

confidence: 99%

Magnesium Oxide Nanomaterial, an Alternative for Commercial Copper Bactericides: Field-Scale Tomato Bacterial Spot Disease Management and Total and Bioavailable Metal Accumulation in Soil

Liao

Huang

Carvalho

et al. 2021

Environ. Sci. Technol.

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Copper (Cu) is the most extensively used bactericide worldwide in many agricultural production systems. However, intensive application of Cu bactericide have increased the selection pressure toward Cu-tolerant pathogens, including Xanthomonas perforans, the causal agent of tomato bacterial spot. However, alternatives for Cu bactericides are limited and have many drawbacks including plant damage and inconsistent effectiveness under field conditions. Also, potential ecological risk on nontarget organisms exposed to field runoff containing Cu is high. However, due to lack of alternatives for Cu, it is still widely used in tomato and other crops around the world in both conventional and organic production systems. In this study, a Cu-tolerant X. perforans strain GEV485, which can tolerate eight tested commercial Cu bactericides, was used in all the field trials to evaluate the efficacy of MgO nanomaterial. Four field experiments were conducted to evaluate the impact of intensive application of MgO nanomaterial on tomato bacterial spot disease severity, and one field experiment was conducted to study the impact of soil accumulation of total and bioavailable Cu, Mg, Mn, and Zn. In the first two field experiments, twice-weekly applications of 200 μg/mL MgO significantly reduced disease severity by 29–38% less in comparison to a conventional Cu bactericide Kocide 3000 and 19–30% less in comparison to the water control applied at the same frequency (p = 0.05). The disease severity on MgO twice-weekly was 12–32% less than Kocide 3000 + Mancozeb treatment. Single weekly applications of MgO had 13–19% higher disease severity than twice weekly application of MgO. In the second set of two field trials, twice-weekly applications of MgO at 1000 μg/mL significantly reduced disease severity by 32–40% in comparison to water control applied at the same frequency (p = 0.05). There was no negative yield impact in any of the trials. The third field experiment demonstrated that application of MgO did not result in significant accumulation of total and bioavailable Mg, Mn, Cu, or Zn in the root-associated soil and in soil farther away from the production bed compared to the water control. However, Cu bactericide contributed to significantly higher Mn, Cu, and Zn accumulation in the soil compared to water control (p = 0.05). This study demonstrates that MgO nanomaterial could be an alternative for Cu bactericide and have potential in reducing risks associated with development of tolerant strains and for reducing Cu load in the environment.

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Antibacterial effect of copper composites against Xanthomonas euvesicatoria

Cited by 23 publications

References 28 publications

A centenary for bacterial spot of tomato and pepper

A centenary for bacterial spot of tomato and pepper

Copper Stimulation of Tetrahydrocannabinol and Cannabidiol Production in Hemp (Cannabis sativa L.) Is Copper-Type, Dose, and Cultivar Dependent

Magnesium Oxide Nanomaterial, an Alternative for Commercial Copper Bactericides: Field-Scale Tomato Bacterial Spot Disease Management and Total and Bioavailable Metal Accumulation in Soil

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