Antibacterial effect of 3-p-trans-coumaroyl-2-hydroxyquinic acid, a phenolic compound from needles ofCedrus deodara, on cellular functions ofStaphylococcus aureus

Wu, Yanping; Bai, Jinrong; Liu, Xiaoyan; Liu, Lijin; Huang, Yina; Gao, Hong

doi:10.1039/c7ra13457f

Cited by 15 publications

(12 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It should also be highlighted that the part of the plant used and the phenolic compound concentration will also have a great influence on the antibacterial activity obtained for each extract. Thus, the antimicrobial activity obtained for both extracts of J. phoenicea could also be related to the presence of phenolic compounds, such as quercetin derivatives and p-coumaroylquinic acid, which are recognized for their antimicrobial actions, 4,44 supporting the antibacterial effectiveness of the studied species.…”

Section: Cytotoxic Effectsmentioning

confidence: 77%

Phenolic profile and in vitro bioactive potential of Saharan Juniperus phoenicea L. and Cotula cinerea (Del) growing in Algeria

et al. 2018

View full text Add to dashboard Cite

The aim of this study was to characterize the individual phenolic profile and antioxidant, anti-inflammatory, cytotoxic, and antimicrobial activities of hydroethanolic and infusion extracts prepared from Algerian Saharan Juniperus phoenicea L. and Cotula cinerea (Del). The phenolic profile was determined using a liquid chromatograph coupled to a diode array detector and an electrospray ionization mass spectrometer (LC-DAD-ESI/MS). A total of thirteen and nine individual phenolic compounds were identified in J. phoenicea and C. cinerea, respectively. 3-p-Coumaroylquinic acid, quercetin- and myricetin-O-pentoside were the major compounds present in J. phoenicea; on the other hand, C. cinerea presented luteolin-7-O-glucoside, luteolin-O-malonylhexoside, and 5-O-caffeoylquinic acid as the main molecules. In general, all samples exhibited interesting antioxidant activity when compared to the standard Trolox, but J. phoenicea extracts presented the highest bioactivity. Likewise, all the samples exhibited anti-inflammatory activity; thus J. phoenicea hydroethanolic extracts showed the highest potential (88 ± 8 μg mL-1). In addition, their cytotoxicity was evaluated towards a panel of four selected cell lines (HeLa, NCI-H460, MCF-7 and HepG2), and all the extracts showed cytotoxic effects, with J. phoenicea extracts being the most effective. The in vitro antimicrobial activity of the plant extracts was moderate, Gram-positive bacteria thus being more sensitive than the Gram-negative strains (MIC values between 5 and 20 mg mL-1). The present work suggests that J. phoenicea and C. cinerea are sources of bioactive ingredients with potential use in the food and pharmaceutical industries.

show abstract

Section: Cytotoxic Effectsmentioning

confidence: 77%

Phenolic profile and in vitro bioactive potential of Saharan Juniperus phoenicea L. and Cotula cinerea (Del) growing in Algeria

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Plant‐based phenolic compounds have been suggested as a valuable source as antioxidants which are capable of scavenging ROS or chelating of metals involved in ROS formation (Ashraf, Sarfraz, & Mahmood, ; Köksal et al, ). In addition, plants with high phenolic compounds have been shown to have a wide variety of other biological activities such as antibacterial, antiviral, antitumor, antidiabetic, and anticancer activity (Altay & Bozoğlu, ; Nazia et al, ; Wu et al, ). Consequently, identification of the major phenolic compounds in medicinal plants and their biological action mechanisms has become the topic of many researchers.…”

Section: Introductionmentioning

confidence: 99%

Preliminary phytochemical analysis and evaluation of in vitro antioxidant, antiproliferative, antidiabetic, and anticholinergics effects of endemicGypsophilataxa from Turkey

et al. 2019

View full text Add to dashboard Cite

The phenolic contents and antioxidant, anticancer, antidiabetic, and anticholinergic potentials of four endemic Gysophila taxa (G. pallida, G. arrosti, G. tuberculosa, and G. eriocalyx) were investigated. The HPLC analysis showed that methanol extracts of all the tested species were richer in phenolics than water extracts. 3,4‐dihydroxybenzoic acid, p‐hydroxybenzoic acid, vanillin, syringic acid, and p‐coumaric acid were detected in all extracts. In parallel to the phenolic contents, methanol extracts displayed comparatively higher antioxidant activity than water extracts. Additionally, all extracts exhibited dose‐dependent antiproliferative activity on the cancer cell lines with lower IC50 values changing from 0.170 to 1.805 mg/ml. Moreover, the extracts impressively inhibited the acetylcholinesterase (0.63–26.04), butyrylcholinesterase (3.66–10.73), and α‐glycosidase (98.52–235.55) enzymes with very low IC50 (mg/ml) values. Together, the present results indicate that Gysophila taxa have various biological activities together with higher phenolic contents. Hence, these species hold good potential for use in the pharmaceutical industry. Practical applications Gypsophila taxa having numerous biological activities have been used for different purpose in folk medicine as well as their use in the food industry. The obtained results of the current study indicated that the extracts of Gypsophila taxa are rich in phenolics and flavonoids with powerful antioxidant and antiproliferative activity against different type of cancer cell lines. In addition, the extracts obtained from these taxa showed notable antidiabetic and anticholinergics effects. Gypsophila taxa could be used as a natural material to develop anticancer, antidiabetic, and anticholinergic drugs.

show abstract

“…1A) from pine needles of Cedrus deodara, which exhibited strong antibacterial activity against S. aureus through damaging bacterial cell membrane and disturbing cellular functions. 24,25 In the present study, we evaluated the inhibitory effect of CHQA on the biolm formation by S. aureus, and further elucidated that the primary antibiolm mechanism of CHQA might be due to the inhibition of the attachment phase of biolm formation by targeting S. aureus SrtA.…”

Section: Introductionmentioning

confidence: 93%

Inhibitory effect of a natural phenolic compound, 3-p-trans-coumaroyl-2-hydroxyquinic acid against the attachment phase of biofilm formation of Staphylococcus aureus through targeting sortase A

Liu

Bai

et al. 2019

RSC Adv.

Self Cite

View full text Add to dashboard Cite

show abstract

Antibacterial effect of 3-p-trans-coumaroyl-2-hydroxyquinic acid, a phenolic compound from needles ofCedrus deodara, on cellular functions ofStaphylococcus aureus

Abstract: Structure–activity relationship of 3-p-trans-coumaroyl-2-hydroxyquinic acid, a phenolic compound from needles of Cedrus deodara, against Staphylococcus aureus and its effect on the cellular functions.

Cited by 15 publications

References 32 publications

Phenolic profile and in vitro bioactive potential of Saharan Juniperus phoenicea L. and Cotula cinerea (Del) growing in Algeria

Phenolic profile and in vitro bioactive potential of Saharan Juniperus phoenicea L. and Cotula cinerea (Del) growing in Algeria

Preliminary phytochemical analysis and evaluation of in vitro antioxidant, antiproliferative, antidiabetic, and anticholinergics effects of endemicGypsophilataxa from Turkey

Inhibitory effect of a natural phenolic compound, 3-p-trans-coumaroyl-2-hydroxyquinic acid against the attachment phase of biofilm formation of Staphylococcus aureus through targeting sortase A

Contact Info

Product

Resources

About