Antibacterial Distribution and Drug–Drug Interactions in Cancer Patients

Theuretzbacher, Ursula; Zeitlinger, Markus

doi:10.1007/978-1-60761-644-3_38

Cited by 3 publications

(4 citation statements)

References 88 publications

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“…The results of the previous research showed that Polygonum capitatum could induce CYP2C9 and CYP3A4 and did not influence CYP1A2, CYP2C19, or CYP2E1 [ 23 ]. According to previous reports, sulfamethoxazole is eliminated mainly by metabolism, and CYP2C9 plays an important role in its N 4 -hydroxylation [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Our previous study indicated that CYP450 activity was induced by treatment with P. capitatum water extract [ 22 ]. However, it is well known that CYP450 enzymes are essential for the metabolism of many medications, including the majority of antibiotics [ 23 ]. Theoretically, the combination of RLQ with ciprofloxacin hydrochloride tablets or compound sulfamethoxazole tablets may lead to herb-drug interaction, while the occurrence of herb-drug interactions may affect the antibiotic activities of ciprofloxacin and sulfamethoxazole.…”

Section: Introductionmentioning

confidence: 99%

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Herb‐Drug Interaction: Effects of Relinqing® Granule on the Pharmacokinetics of Ciprofloxacin, Sulfamethoxazole, and Trimethoprim in Rats

Lü

Gong

Xie

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Relinqing granule (RLQ) is the best-selling Chinese patent drug for treatment of urinary system diseases. In this study, the effects of RLQ on the pharmacokinetics of ciprofloxacin, sulfamethoxazole, and trimethoprim in SD rats were investigated. Rats were randomly divided into control group 1, control group 2, RLQ group 1, and RLQ group 2. RLQ group 1 and RLQ group 2 were treated orally with RLQ for 7 days, and rats were treated with the same volume of water in control group 1 and control group 2. Then, RLQ group 1 and control group 1 were given intragastrically ciprofloxacin on day 8, while RLQ group 2 and control group 2 were given intragastrically sulfamethoxazole and trimethoprim on day 8. Blood samples were collected and determined. There was no significant influence of pharmacokinetic parameters of trimethoprim on two groups. But some pharmacokinetic parameters of ciprofloxacin and sulfamethoxazole in RLQ pretreated rats were evidently altered (P < 0.05), which indicated that absorption of ciprofloxacin and sulfamethoxazole in RLQ pretreated rats was significantly affected. It indicated the coadministration of RLQ would have an influence on the efficacy of ciprofloxacin and sulfamethoxazole, and the doses of ciprofloxacin tablet and compound sulfamethoxazole tablet need adjustment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Herb‐Drug Interaction: Effects of Relinqing® Granule on the Pharmacokinetics of Ciprofloxacin, Sulfamethoxazole, and Trimethoprim in Rats

Lü

Gong

Xie

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…It is always co-administered with quinolones, macrolides and other antibiotics. Cytochrome P450 (CYP) enzymes are essential for the metabolism of many medications, including the majority of antibiotics (Theuretzbacher and Zeitlinger, 2011). However, no systematic study of the impact of Polygonum capitatum on hepatic CYP enzyme activities has been reported to date Q3 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the impact of Polygonum capitatum, a traditional Chinese herbal medicine, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs

Zheng

Lü

Cao

et al. 2014

Journal of Ethnopharmacology

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“…Low albumin concentrations reduce plasma oncotic pressure, subsequently leading to enhanced fluid extravasation. However, the effect of hypoalbuminemia is most prominent for highly protein-bound antibiotics and therefore might have limited contribution toward the increased piperacillin V observed in this study (30% protein binding) (4,15). Changes in the glomerular filtration rate (GFR) have been implicated in the variability of antibiotic CL in febrile patients with hematological malignancies (6).…”

mentioning

confidence: 95%

Altered Pharmacokinetics of Piperacillin in Febrile Neutropenic Patients with Hematological Malignancy

Sime

Roberts

Warner

et al. 2014

Antimicrob Agents Chemother

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h This study assessed the pharmacokinetics and dosing adequacy of piperacillin in febrile neutropenic patients after the first dose. Pharmacokinetic analysis was performed using noncompartmental methods. We observed an elevated volume of distribution (29.7 ؎ 8.0 liters [mean ؎ standard deviation]) and clearance (20.2 ؎ 7.5 liters/h) compared to data from other patient populations. Antibiotic exposure did not consistently result in therapeutic targets. We conclude that alternative dosing strategies guided by therapeutic drug monitoring may be required to optimize exposure.

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Antibacterial Distribution and Drug–Drug Interactions in Cancer Patients

Cited by 3 publications

References 88 publications

Herb‐Drug Interaction: Effects of Relinqing® Granule on the Pharmacokinetics of Ciprofloxacin, Sulfamethoxazole, and Trimethoprim in Rats

Herb‐Drug Interaction: Effects of Relinqing® Granule on the Pharmacokinetics of Ciprofloxacin, Sulfamethoxazole, and Trimethoprim in Rats

Evaluation of the impact of Polygonum capitatum, a traditional Chinese herbal medicine, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs

Altered Pharmacokinetics of Piperacillin in Febrile Neutropenic Patients with Hematological Malignancy

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