Antibacterial Compounds from Mushrooms I: A Lanostane-Type Triterpene and Prenylphenol Derivatives fromJahnoporus hirtusandAlbatrellus flettiiand Their Activities AgainstBacillus cereusandEnterococcus faecalis

Liu, Xueting; Winkler, Abby L.; Schwan, William R.; Volk, Thomas; Rott, Marc; Monte, Aaron

doi:10.1055/s-0029-1186001

Cited by 39 publications

(28 citation statements)

References 18 publications

(36 reference statements)

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“…Confluentin (1a), grifolin (1b), and neogrifolin (1c) from Albatrellus fletti showed activity against Bacillus cereus and Enterococcus faecalis. The best result was for Enterococcus faecalis (MIC 0.5 to 1.0 mg/mL)[56]. Ganomycin A and B (5 a, b), isolated from Ganoderma pfeifferi, showed activity against Bacillus subtilis, Micrococcus flavus, and Staphylococcus aureus (15-25 mm zones of inhibition at a concentration of 250 µg/mL[57].…”

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“…Ganomycin A and B (5 a, b), isolated from Ganoderma pfeifferi, showed activity against Bacillus subtilis, Micrococcus flavus, and Staphylococcus aureus (15-25 mm zones of inhibition at a concentration of 250 µg/mL[57]. A steroid, 3,11-dioxolanosta-8,24(Z)-diene-26-oic acid (2), was isolated from the Jahnoporus hirtus mushroom and revealed activity against Bacillus cereus and Enterococcus faecalis[56]. Four sesquiterpenes with antimicrobial activity were described.…”

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A Review on Antimicrobial Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds

et al. 2012

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Despite the huge diversity of antibacterial compounds, bacterial resistance to first-choice antibiotics has been drastically increasing. Moreover, the association between multiresistant microorganisms and nosocomial infections highlight the problem, and the urgent need for solutions. Natural resources have been exploited in the last years and among them, mushrooms could be an alternative source of new antimicrobials. In this review, we present an overview of the antimicrobial properties of mushroom extracts and highlight some of the active compounds identified, including low- and high-molecular weight (LMW and HMW, respectively) compounds. LMW compounds are mainly secondary metabolites, such as sesquiterpenes and other terpenes, steroids, anthraquinones, benzoic acid derivatives, and quinolines, but also primary metabolites such as oxalic acid. HMW compounds are mainly peptides and proteins. Data available from the literature indicate a higher antimicrobial activity of mushroom extracts against gram-positive bacteria. Among all the mushrooms, Lentinus edodes is the most studied species and seems to have a broad antimicrobial action against both gram-postive and gram-negative bacteria. Plectasin peptide, obtained from Pseudoplectania nigrella, is the isolated compound with the highest antimicrobial activity against gram-positive bacteria, while 2-aminoquinoline, isolated from Leucopaxillus albissimus, presents the highest antimicrobial activity against gram-negative bacteria.

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A Review on Antimicrobial Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds

et al. 2012

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“…As part of an ongoing screening program aimed at finding new antibacterial compounds from fungi [1], the dichloromethane crude extract of Fomitopsis pinicola (Swartz ex Fr.) Karst showed activity against Bacillus cereus in standard disc diffusion assays (DDAs).…”

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Antibacterial Compounds from Mushrooms II: Lanostane Triterpenoids and an Ergostane Steroid with Activity AgainstBacillus cereusIsolated fromFomitopsis pinicola

et al. 2009

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Anti- Bacillus cereus bioassay-guided fractionation of a crude extract of the American mushroom, Fomitopsis pinicola, was performed using thin-layer chromatography, Sephadex LH-20 column chromatography, and preparative-scale HPLC. Five lanostane triterpenoids (1-5) and one ergostane steroid (6) were isolated and identified. Compound 1 is a new lanostane triterpenoid, and its structure was determined using 1D and 2D NMR experiments, HR-MS, and physical data. Each of the purified compounds (1-6) was tested for antibacterial activity against B. cereus using standard MIC assays. Compounds 1-6 had MIC values of 32, 16, 32, 32, 128, and 64 microg/mL, respectively.

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“…In recent studies, natural agents have been widely used for cancer therapy. Grifolin (2-trans, trans-farnesyl-5-methylresorcinol), a secondary metabolite extracted from the mushroom Albatrellus confluens, is an antibiotic belonging to basidiomycota (2,3). Several mechanisms have been reported, including inhibition of G1 phase cell cycle (4-6), promotion of apoptosis proteins (7,8) suppression of cell metastasis (9) which have been proposed to explain grifolin's antitumor effects.…”

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Grifolin induces autophagic cell death by inhibiting the Akt/mTOR/S6K pathway in human ovarian cancer cells

et al. 2016

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Abstract. Grifolin, a secondary metabolic product isolated from the mushroom Albatrellus confluence, has been reported to possess antitumor activities in various tumors. To date, no report exists on the role of autophagy in grifolin-treated human ovarian cancer cells. In the present study, we investigated the effect and the mechanism of autophagy in ovarian cancer. Ovarian cancer cell lines A2780 and SKOV3 were treated with grifolin. Cell proliferation was assessed by MTT assay and the autophagic effect was determined using flow cytometry, electron microscopy, immunofluorescence staining and GFP-LC3 puncta formation assay. The expression of autophagy markers and the main autophagy-associated Akt/ mTOR/S6K pathway proteins were measured by western blot analysis. MTT assay indicated that grifolin inhibits the proliferation of human ovarian cancer cell lines A2780 and SKOV3. Flow cytometry, electron microscopy, immunofluorescence and GFP-LC3 puncta formation assay proved that grifolin induces autophagic cell death in human ovarian cancer. The results of the western blot analysis suggested that grifolin treatment leads to upregulation of autophagy markers LC3B, Atg7, Beclin-1 along with downregulation of P62. In addition, the proteins of the pathways p-Akt, p-mTOR, p-p70S6K and p-4E-BP1 were downregulated while the total of these proteins remained unaffected. The present study indicated that grifolin could induce autophagic cell death in human ovarian cancer by inhibiting the Akt/mTOR/S6K pathway.

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Antibacterial Compounds from Mushrooms I: A Lanostane-Type Triterpene and Prenylphenol Derivatives fromJahnoporus hirtusandAlbatrellus flettiiand Their Activities AgainstBacillus cereusandEnterococcus faecalis

Cited by 39 publications

References 18 publications

A Review on Antimicrobial Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds

A Review on Antimicrobial Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds

Antibacterial Compounds from Mushrooms II: Lanostane Triterpenoids and an Ergostane Steroid with Activity AgainstBacillus cereusIsolated fromFomitopsis pinicola

Grifolin induces autophagic cell death by inhibiting the Akt/mTOR/S6K pathway in human ovarian cancer cells

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