Antibacterial coating of titanium-doped hydroxyapatite nanoparticles on a polymer substrate

Abstract

Calcined and dispersible titanium-doped hydroxyapatite (Ti-HAp) nanoparticles at different [Ti/(Ca+Ti)] atomic ratios (0.3, 0.4, and 0.5) were prepared using an anti-sintering method. The Ti substitution ratios of the HAp structures in the feed of Ti-HAp preparation were approximately 80%. Ti-HAp nanoparticles were coated on polyethylene terephthalate (PET) sheets through polyacrylic acid graft-polymers. The PET substrate was almost completely covered with monolayer nanoparticles (over 95%). Antibacterial activity of coated Ti-HAp was calculated from the survival ratio of the bacteria, Staphylococcus aureus, after ultraviolet (UV) irradiation at 312 nm and 6.4 mW/cm2 for 30 s. The number of S. aureus on the Ti-HAp coated substrate decreased by 43% compared to those on the original PET and normal HAp coatings as negative controls. The antibacterial activity of Ti-HAp coated substrate was, furthermore, no statistically difference with TiO2 sheet as a positive control.

Continuous antimicrobial mechanism of dispersible hydroxyapatite nanoparticles doped with zinc ions for percutaneous device coatings

“…Graft-polymerization with polyAA (PAA) on PET sheets by corona discharge treatment was conducted according to a previous report. 14 PAA-grafted PET (PAA-g-PET) sheets with an approximate density of 10 μg/cm 2 were coated with Zn-HAp nanoparticles via ionic interactions. PAA-g-PET sheets (50 × 40 mm) were immersed in a solution of 3 mg/ mL Zn-HAp nanoparticles dispersed in ethanol (200 mL) and stirred for 0.5 h. The Zn-HAp-coated sheets were dried for 24 h at room temperature.…”

“…In our research group, highly dispersible and crystalline hydroxyapatite [HAp, Ca 10 (PO 4 ) 6 (OH) 2 ] nanoparticles doped with metallic or halogen ions with antibacterial effects and suitability for nano-coating on polymer substrates have been developed. [12][13][14][15] It is well-known that HAp is a biocompatible material that is a main component of teeth and bones, 16 and can be substituted with various ions in the HAp lattice due to inherent ion-exchange properties, aiming to elevate its biological functionalities. 17 This study focused on the antibacterial and allergenic properties of dispersible and crystalline Zn ion-doped HAp (Zn-HAp) nanoparticles, which represent one of the essential biological trace elements.…”

Shareability of antibacterial and osteoblastic‐proliferation activities of zinc‐doped hydroxyapatite nanoparticles in vitro

“…14,15 Moreover, ions (silver, fluoride, or titanium)-doped HAp nanoparticles were also prepared by the method. [16][17][18][19][20] In particular, the antibacterial activities of ion-doped HAp nanoparticles were evaluated against several types of pathogenic microorganisms.…”

Antimicrobial Nanomaterials: A Review

“…As a result, the researchers found that the number of S. aureus on the Ti-HAp-coated substrate was reduced by 43% compared to those on the normal HAp and original PET coating [98]. Ghule et al reported for the first time that ZnO nanoparticles can be coated on cellulose fibers of paper by using an ultrasonic approach.…”