Antibacterial biomaterials in bone tissue engineering

Abstract

Bone infection is a devastating disease with recurrent, drug-resistant, and high morbidity features, that have prompted clinicians and scientists to develop novel approaches to combat it. Currently, although numerous biomaterials...

Synergic effect of aqueous extracts of Ocimum sanctum and Trigonella foenum-graecum L on the in situ green synthesis of silver nanoparticles and as a preventative agent against antibiotic-resistant food spoiling organisms

“…in plant extract which synergistically interfering in more efficiently way with bacterial cell wall and shows more effect on cellular interaction leading to cell death. 30,57–62 These results show that Ag NPs exhibit potential antimicrobial activity and food preservation activity, even at low concentration.…”

“… 29 However, recent interest on Ag NPs has particularly focused on the increasing threat of antibiotic resistance due to the excessive use/abuse of antibiotics. 30 …”

“…Recently, the synthesis of Ag NPs via a biological reduction method has been developed as a promising technique because of its special advantages, such as mild reaction conditions, nontoxic reagents, and absence of synthetic chemical additives as the stabilizing or reducing agents of the NPs. 30 Because of their environmentally-friendly nature, biosynthetic processes are being researched for the synthesis of Ag NPs. 37 In biosynthesis methods, the reaction time for the reduction of silver ions requires more time due to the slow rate of the reaction.…”

Advances in Copper-Based Biomaterials With Antibacterial and Osteogenic Properties for Bone Tissue Engineering

“…Therefore, the biotoxicity of copper-based biomaterials should be evaluated before it is used in bone tissue engineering. It has been demonstrated that the toxicity of copper-based biomaterials is reduced by optimizing copper doping concentration, releasing curve or reducing metal particle size ( Chen et al, 2021 ). At the same time, biocompatibility and antibacterial ability must also be achieved.…”

Mg-, Zn-, and Fe-Based Alloys With Antibacterial Properties as Orthopedic Implant Materials

“…Therefore, an alternative is urgently needed to avoid the short life cycles of antibiotic-eluting devices and provide the implants with a lasting antibacterial effect. In light of this, the inherent antibacterial properties of some implant materials have gained increasing attention from researchers ( Tran et al, 2015 ; Xu et al, 2016 ; Bee et al, 2021 ; Calabrese et al, 2021 ; Chen et al, 2021 ).…”