Antibacterial behavior of organosilicon composite with nano aluminum oxide without influencing animal cells

Astashev, Maxim E.; Sarimov, Ruslan M.; Serov, Dmitriy A.; Matveeva, Tatiana; Simakin, Alexander V.; Ignatenko, Dmitry N.; Burmistrov, Dmitriy; Smirnova, Veronika V.; Kurilov, Alexander D.; Mashenko, V.I.; Ivashkin, Petr I.; Уваров, О. В.; Voronov, V. V.; Shkirin, A. V.; Nagaev, Egor V.; Ефимов, А Д; Иванов, В. Э.; Брусков, В. И.; Dubinin, Mikhail V.; Шарапов, М. Г.; Козлов, В. А.; Bunkin, N. F.; Volkov, Mikhail Yu; Vedunova, Maria; Rebezov, Мaksim; Семенова, А.А.; Lisitsyn, Andrey B.; Glinushkin, Alexey; Чаусов, Д. Н.; Gudkov, Sergey V.

doi:10.1016/j.reactfunctpolym.2021.105143

Cited by 13 publications

(15 citation statements)

References 37 publications

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“…Various approaches for AlOxNP synthesis are used including bottom-up and top- down methods. The most used top-down methods are laser ablation [ 28 , 29 ] and ball milling [ 30 ]. Other methods include sol–gel process [ 31 ], microemulsion method [ 32 ], microwave processing, [ 19 , 33 , 34 ], solvothermal synthesis [ 35 ], and combustion [ 36 ].…”

Section: Literature Reviewmentioning

confidence: 99%

A Mini Review of Antibacterial Properties of Al2O3 Nanoparticles

et al. 2022

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Bacterial antibiotic resistance is one of the most serious modern biomedical problems that prioritizes the search for new agents to combat bacterial pathogens. It is known that nanoparticles of many metals and metal oxides can have an antibacterial effect. However, the antibacterial efficacy of aluminum oxide nanoparticles has been studied little compared to the well-known antimicrobial properties of nanoparticles of oxides of metals such as zinc, silver, iron, and copper. In this review, we have focused on the experimental studies accumulated to date demonstrating the antibacterial effect of aluminum oxide nanoparticles. The review discusses the main ways of synthesis and modification of these nanoparticles, provides the proposed mechanisms of their antibacterial action against gram-positive and gram-negative bacteria, and also compares the antibacterial efficacy depending on morphological characteristics. We have also partially considered the activity of aluminum oxide nanoparticles against water microalgae and fungi. In general, a more detailed study of the antibacterial properties of aluminum oxide nanoparticles is of great interest due to their low toxicity to eukaryotic cells.

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Section: Literature Reviewmentioning

confidence: 99%

A Mini Review of Antibacterial Properties of Al2O3 Nanoparticles

et al. 2022

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“…The most commonly used polymer matrices are chitosan [ 74 , 78 , 79 ], starch [ 80 ], and thermoplastic synthetic materials [ 76 , 77 , 81 ]. It is also possible to use organo-silicon polymers with controlled physicochemical properties and biodegradable polymers [ 57 , 58 ]. A wide range of polymers “compatible” with ZnO NPs expands the range of possible applications of nanocomposites based on ZnO NPs.…”

Section: Discussionmentioning

confidence: 99%

“…In most studies, spherical ZnO NPs were obtained by chemical synthesis methods, and they had a spherical shape [ 78 , 79 , 82 , 83 ]. Laser ablation makes it possible to obtain rod-shaped ZnO NPs with an expected higher antimicrobial activity [ 57 , 58 ]. Secondly, for fluoroplast, the ability to prevent the adhesion of microorganisms to surfaces treated with it has been described [ 21 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Combining a polymer matrix and metal oxide NPs can be a new step in the creation of materials with the desired physical properties and protection against bacterial contamination. We have previously obtained materials based on polymeric matrices of borosiloxane or PLGA and nanoparticles of silver, aluminum, iron, and zinc oxides [ 57 , 58 , 59 , 60 ]. The previously obtained materials possessed good antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

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Composite Coating for the Food Industry Based on Fluoroplast and ZnO-NPs: Physical and Chemical Properties, Antibacterial and Antibiofilm Activity, Cytotoxicity

et al. 2022

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Bacterial contamination of meat products during its preparation at the enterprise is an important problem for the global food industry. Cutting boards are one of the main sources of infection. In order to solve this problem, the creation of mechanically stable coatings with antibacterial activity is one of the most promising strategies. For such a coating, we developed a composite material based on “liquid” Teflon and zinc oxide nanoparticles (ZnO-NPs). The nanoparticles obtained with laser ablation had a rod-like morphology, an average size of ~60 nm, and a ζ-potential of +30 mV. The polymer composite material was obtained by adding the ZnO-NPs to the polymer matrix at a concentration of 0.001–0.1% using the low-temperature technology developed by the research team. When applying a composite material to a surface with damage, the elimination of defects on a micrometer scale was observed. The effect of the composite material on the generation of reactive oxygen species (H2O2, •OH), 8-oxoguanine in DNA in vitro, and long-lived reactive protein species (LRPS) was evaluated. The composite coating increased the generation of all of the studied compounds by 50–200%. The effect depended on the concentration of added ZnO-NPs. The antibacterial and antibiofilm effects of the Teflon/ZnO NP coating against L. monocytogenes, S. aureus, P. aeruginosa, and S. typhimurium, as well as cytotoxicity against the primary culture of mouse fibroblasts, were studied. The conducted microbiological study showed that the fluoroplast/ZnO-NPs coating has a strong bacteriostatic effect against both Gram-positive and Gram-negative bacteria. In addition, the fluoroplast/ZnO-NPs composite material only showed potential cytotoxicity against primary mammalian cell culture at a concentration of 0.1%. Thus, a composite material has been obtained, the use of which may be promising for the creation of antibacterial coatings in the meat processing industry.

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“…[ 4 ]. In some cases, the oxides of various metals are embedded into the bulk of the polymer to promote the generation of reactive oxygen species (ROS) inside the membrane; see, for example, studies [ 5 , 6 , 7 ]. The effect of ROS generation is widely applied in agriculture, specifically in greenhouses based on polymer films for the destruction of bacterial cell walls and their subsequent death; see, for example, [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Methylene Blue on the Surface of Polymer Membrane; Dependence on the Isotopic Composition of Liquid Matrix

et al. 2022

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As was found in our previous works, when Nafion swells in water, polymer fibers unwind into the bulk of the surrounding liquid. This effect is controlled by the content of deuterium in water. Here, we present the results of studying the dynamics of methylene blue (MB) adsorption on the Nafion surface for MB solutions based on natural water (deuterium content is 157 ppm, the unwinding effect occurs) and based on deuterium-depleted water (DDW; deuterium content is 3 ppm, there is no unwinding). In addition, we studied the dynamics of water desorption during drying of the Nafion polymer membrane after soaking in MB solution based on natural water and DDW. It turned out that in the case of natural water, the rate of MB adsorption and water desorption is higher than in the case of DDW. It also turned out that the amount of MB adsorbed on the membrane in the case of natural water is greater than in the case of DDW. Finally, it was found that the desorption of water during drying is accompanied by a rearrangement of the absorption spectrum of Nafion. This rearrangement occurs earlier in the case of DDW. Thus, by infinitesimal changes in the deuterium content (from 3 to 157 ppm) in an aqueous solution, in which a polymer membrane swells, we can control the dynamics of adsorption and desorption processes. A qualitative model, which connects the observed effects with the slowing down of diffusion processes inside the layer of unwound fibers, is proposed.

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Antibacterial behavior of organosilicon composite with nano aluminum oxide without influencing animal cells

Cited by 13 publications

References 37 publications

A Mini Review of Antibacterial Properties of Al2O3 Nanoparticles

A Mini Review of Antibacterial Properties of Al2O3 Nanoparticles

Composite Coating for the Food Industry Based on Fluoroplast and ZnO-NPs: Physical and Chemical Properties, Antibacterial and Antibiofilm Activity, Cytotoxicity

Adsorption of Methylene Blue on the Surface of Polymer Membrane; Dependence on the Isotopic Composition of Liquid Matrix

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