Antibacterial, antisecretory and antihemorrhagic activity of Azadirachta indica used to treat cholera and diarrhea in India

Thakurta, Prarthana; Bhowmik, Poulami; Mukherjee, Souryadeep; Hajra, Tapas K.; Patra, Amarendra; Bag, Prasanta K.

doi:10.1016/j.jep.2007.01.022

Cited by 111 publications

(80 citation statements)

References 21 publications

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“…The susceptibility of V. cholerae to vegetable extracts was also tested by THAKURTA et al 40 who found serotypes O1, O139, non-O1 and non-O139 to be inhibited by extracts of the neem tree (Azadirachta indica). Moreover, AKINSINDE & OLUKOYA 1 observed vibriocidal effects of medicinal plants from Nigeria, and in a study testing the bactericidal effect in vitro of 14 plant species upon V. cholerae, GUEVARA et al 19 proposed using extracts of pomegranate peel (Punica granatum), the most efficient of the samples, as an alternative treatment for cholera.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial effect (in vitro) of Moringa oleifera and Annona muricata against Gram positive and Gram negative bacteria

Viera

Mourão

Ângelo

et al. 2010

Rev. Inst. Med. trop. S. Paulo

144

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SUMMARYAntibacterial effects of aqueous and ethanolic extracts of seeds of moringa (Moringa oleifera) and pods of soursop (Annona muricata) in the concentration of 1:5 and 1:10 in volumes 50, 100, 150 and 200 μL were examined against Staphylococcus aureus, Vibrio cholerae, Escherichia coli (isolated from the organism and the aquatic environment) and Salmonella Enteritidis. Antibacterial activity (inhibition halo > 13 mm) against S. aureus, V. cholerae and E. coli isolated from the whiteleg shrimp, Litopenaeus vannmaei, was detected in aqueous and ethanolic extracts of moringa. E. coli isolated from tilapiafish, Oreochromis niloticus, was sensitive to the ethanolic extract of moringa. The aqueous extracts of soursop showed an antibacterial effect against S. aureus and V. cholerae, but the antibacterial activity by the ethanol extracts of this plant was not demonstrated.

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Section: Resultsmentioning

confidence: 99%

Antibacterial effect (in vitro) of Moringa oleifera and Annona muricata against Gram positive and Gram negative bacteria

Viera

Mourão

Ângelo

et al. 2010

Rev. Inst. Med. trop. S. Paulo

144

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“…The antibacterial test was conducted by the agar dilution method using the general procedure outlined by Thakurta et al [21]. The cultural concentration of bacteria was E. coli= 4.2×10 8 cfu/mL and S. Aureus = 3.2×10 7 cfu/mL.…”

Section: Biological Activities Evaluationmentioning

confidence: 99%

Antibacterial and Cytotoxic Potencies of Stilbene Oligomers From Stem Barks of Baoti (Dryobalanops Lanceolata) Growing in Kendari, Indonesia

Sahidin

Wahyuni²,

Malaka³

et al. 2017

Asian J Pharm Clin Res

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Objective: The purpose of the research is to isolate and to identify compounds from stem barks of Dryobalanops lanceolata and to evaluate their activities toward bacteria and cancer cell lines. Methods:Isolation of the compounds worked with chromatography methods including thin-layer chromatography, vacuum liquid chromatography, and radial chromatography. All compound structures were determined based on the spectroscopic evidence including ultraviolet (UV), Infrared, and one-dimension and two-dimension nuclear magnetic resonance spectra and comparison the spectroscopy data with related data from references. The biological properties of compounds are evaluated toward bacteria Escherichia coli ATCC 35219 and Staphylococcus aureus ATCC 25923 and human breast cancer cell lines T-47D as cytotoxic potency.Results: Five stilbene oligomers have been isolated and identified from acetone extract of D. lanceolata stem barks namely balanocarpol (1), e-viniferin (2), a-viniferin (3), vaticanol B (4), and hopeaphenol (5). The inhibition zone value (in mm) of e-viniferin, balanocarpol, a-viniferin, hopeaphenol, and vaticanol B toward E. coli and S. aureus is 11±0.22 and 7±0.17, 9±0.17 and 13±0.12, 8±0.20 and 8±0.16, 6±0.16 and 8±0.11, and 5±0.12 and 4±0.14, respectively. Biological activity of the compounds against breast cancer cell lines T-47D (inhibitory concentration 50% in µM) for e-viniferin, balanocarpol, a-viniferin, hopeaphenol, and vaticanol B is 34.13±0.15, 98.17±0.41, 84.79±0.24, 52.04±0.26, and 119.30±0.54, respectively.Conclusions: e-viniferin is the most active compound toward E. coli and human breast cancer cell lines T-47D. Biological activity against bacteria S. aureus indicated that balanocarpol is the most potential compound.

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“…Among the clinical strains of Vibrio cholerae used in this study, strain NB2 belongs to the O1 serotype and strain SG24(1) belongs to the O139 serotype. These strains are able to produce cholera toxin and hemolysin (24,25). The other strains used in this study were non-O1 and non-O139 strains of V. cholerae (strains CO6 and PC2) (24) and strains of Shigella flexneri (26).…”

Section: Microorganismsmentioning

confidence: 99%

“…Accordingly, compound 3 had significant antibacterial activity against V. cholerae CO6, V. cholerae NB2, V. cholerae PC2, S. flexneri, and S. aureus while compound 6 had significant antibacterial activity against Shigella flexneri SDINT and Staphylococcus aureus ATCC 25923. The strains of V. cholerae NB2, PC2 (24,25) and Shigella flexneri (26) included in the present study were MDR clinical isolates and these were resistant to commonly used drugs such as ampicillin, streptomycin, tetracycline, nalidixic acid, furazolidone, and co-trimoxazole. However, most of the tested samples displayed antibacterial activity against these microbial strains, suggesting that their administration may represent an alternative treatment for V. cholerae, the cause of the dreadful disease cholera, and S. flexneri, the cause of shigellosis.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Complex secondary metabolites from <i>Ludwigia leptocarpa</i> with potent antibacterial and antioxidant activities

Mabou

Tamokou

Ngnokam

et al. 2016

DD&T

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Antibacterial, antisecretory and antihemorrhagic activity of Azadirachta indica used to treat cholera and diarrhea in India

Cited by 111 publications

References 21 publications

Antibacterial effect (in vitro) of Moringa oleifera and Annona muricata against Gram positive and Gram negative bacteria

Antibacterial effect (in vitro) of Moringa oleifera and Annona muricata against Gram positive and Gram negative bacteria

Antibacterial and Cytotoxic Potencies of Stilbene Oligomers From Stem Barks of Baoti (Dryobalanops Lanceolata) Growing in Kendari, Indonesia

Complex secondary metabolites from <i>Ludwigia leptocarpa</i> with potent antibacterial and antioxidant activities

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