Antibacterial, antifungal and cytotoxic activities exhibited by endophytic fungi from the Brazilian marine red alga Bostrychia tenella (Ceramiales)

Felício, Rafael de; Pavão, Gabriel Brolio; Oliveira, Ana Lígia Leandrini de; Erbert, Cíntia; Conti, Raphael; Pupo, Mônica Tallarico; Furtado, Niege Araçari Jacometti Cardoso; Ferreira, Elthon G.; Costa-Lotufo, Letı́cia V.; Young, Maria Cláudia M.; Yokoya, Nair S.; Debonsi, Hosana Maria

doi:10.1016/j.bjp.2015.08.003

Cited by 63 publications

(44 citation statements)

References 69 publications

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“…isolated from Cinnamomum mollissimum offered potent cytotoxicity against murine leucemia cells (Santiago et al 2012). Also, the ethyl acetate extract of endophytic fungi isolated from P. crocatum and red alga Bostrychia tenella inhibited the growth of different tumour cell lines with IC 50 value of 37.43 (T47D) and 1 lg/mL (SF-295), respectively (Astuti et al 2014;de Felicio et al 2015). It was also noted that EAC cells without the treatment of extract had no cytotoxicity effect in the present study.…”

Section: Anticancer and Dna Fragmentation Assaymentioning

confidence: 56%

Molecular profiling and bioactive potential of an endophytic fungus Aspergillus sulphureus isolated from Sida acuta : a medicinal plant

Murali

Mahendra

Hema

et al. 2017

Pharmaceutical Biology

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Context: Sida acuta Burm.f. (Malvaceae) extracts are reported to have applications against malaria, diuretic, antipyretic, nervous and urinary diseases. No fungal endophytes of S. acuta are reported. Objective: Isolation, identification and evaluation of antibacterial, antioxidant, anticancer and haemolytic potential of fungal endophytes from the ethnomedcinal plant S. acuta. Materials and methods: Sida acuta stem segments were placed on PDA medium to isolate endophytic fungi. The fungus was identified by genomic DNA analysis and phylogenetic tree was constructed using ITS sequences (GenBank) to confirm species. The antibacterial efficacy of Aspergillus sulphureus MME12 ethyl acetate extract was tested against Gram-positive and Gram-negative pathogenic bacteria. DPPH free radical scavenging activity, anticancer and DNA fragmentation against EAC cells, and direct haemolytic activity (100-500 lg/mL) using human erythrocytes were determined. Results and discussion: The ethyl acetate extract of A. sulphureus (Fresen.) Wehmer (Trichocomaceae) demonstrated significant antibacterial potential against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Salmonella typhi compared to streptomycin. MIC against test pathogens was in the range of 15.6-62.5 lg/mL. The antioxidant results revealed significant RSA from 12.43% to 62.02% (IC 50 ¼ 350.4 lg/ mL, p 0.05). MME12 offered considerable inhibition of EAC proliferation (23% to 84%, IC 50 ¼ 216.7 lg/mL, p 0.05) supported by DNA fragmentation studies. The extract also offered insignificant haemolysis (5.6%) compared to Triton X-100. Conclusions: A single endophytic fungus, A. sulphureus MME12 was isolated and identified using molecular profiling. The above-mentioned findings support the pharmacological application of A. sulphureus MME12 extract and demand for purification of the active principle(s).

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Section: Anticancer and Dna Fragmentation Assaymentioning

confidence: 56%

Molecular profiling and bioactive potential of an endophytic fungus Aspergillus sulphureus isolated from Sida acuta : a medicinal plant

Murali

Mahendra

Hema

et al. 2017

Pharmaceutical Biology

View full text Add to dashboard Cite

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“…and Phoma pinodella can produce phenolics like phomodione, usnic acid, cercosporamide, pestalol D and E and several others, some of which have antiproliferative activity against a panel of human cancer cell lines (lung, prostate, ovary, colon, cervix, pancreas and malignant tumor of melanoma) [14]. Immunosuppression for kidney transplant recipients [18] Dicerandrol C (xanthone) Antimicrobial actions against S. aureus [19,20] Cytosporone B and C (phenylacetates)…”

Section: Biosynthesis Of Phenolic Compounds In Fungimentioning

confidence: 99%

“…Inhibitory action against C. albicans and Fusarium oxysporum [20] Phomopsin A and B (mycotoxins) Antiviral, antibacterial and antifungal activities [21] Altersolanol A, B and N (anthraquinone)…”

Section: Biosynthesis Of Phenolic Compounds In Fungimentioning

confidence: 99%

Beyond Enzyme Production: Solid State Fermentation (SSF) as an Alternative to Produce Antioxidant Polysaccharides

Gutiérrez-Uribe¹,

Verduzco-Oliva²

2019

Preprint

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Solid state fermentation (SSF) is considered more sustainable than traditional fermentation because it uses low amounts of water and transforms agro-industrial residues into value added products. Enzymes, biofuels, nanoparticles and bioactive compounds can be obtained from SSF. The key factor in SSF processes is the choice of microorganisms and their substrates. Many fungal species can be used and are mainly used due their lower requirements of water, O2 and light. Residues rich in soluble and insoluble fiber are utilized by lignocellulolytic fungi because they have the enzymes that break fiber hard structure (lignases, celullases or hemicelullases). During the hydrolysis of lignin, some phenolic compounds are released but fungi also synthetize compounds such as mycophenolic acid, dicerandrol C, phenylacetates, anthraquinones, benzofurans and alkenyl phenols that have health beneficial effects such as antitumoral, antimicrobial, antioxidant and antiviral activities. Another important group of compounds synthetized by fungi during fermentation are polysaccharides that also have important health promoting properties. Fungal biofermentation has also proved to be a process which can release high contents of phenolics and it also increases the bioactivity of these compounds.

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“…Penicillium chrysogenum QEN 24S, an endophytic fungus isolated from an unidentified marine red algal species of genus Laurencia, yielded penicitide A, which possessed moderate cytotoxic activity against a human liver carcinoma cell line with IC 1.8 μg/ml) [59]. Recently, a culture of the fungus Xylaria sp., isolated from Brazilian marine seaweed Bostrychia tenella, yielded cytochalasin D, which expressed moderate activity against tumor cells SF-295 and HCT-8 [60] (Fig. 4).…”

Section: Anticancer Compoundsmentioning

confidence: 99%

Marine Algicolous Endophytic Fungi - A Promising Drug Resource of the Era

Sarasan

Puthumana

Job

et al. 2017

Journal of Microbiology and Biotechnology

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Endophytic fungi have currently been acknowledged as the most promising source of bioactive compounds for drug discovery, and considerable progress has been made in exploring their diversity, species richness, and bioprospecting. Fungal endophytes from unique environmental settings offer a pool of potentially useful medicinal entities. Owing to the constant stresses imposed on macroalgae by marine environments, it is believed that algae and their associated endophytic symbionts represent a good source of structurally diverse bioactive secondary metabolites. Despite the proven significance of active metabolites of algal endophytes, little have been exploited. This review highlights the latest discoveries in algicolous endophytic research, with particular focus on the bioactive metabolites from algal endophytes. Compounds are classified according to their reported biological activities, like anticancer, antibacterial, antifungal, and antioxidant properties. Present experimental evidence suggests that a majority of the bioactive metabolites were reported from Phaeophyceae followed by Rhodophyceae and Chlorophyceae. An intensive search for newer and more effective bioactive metabolites has generated a treasure trove of publications, and this review partially covers the literature published up to 2016.

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Antibacterial, antifungal and cytotoxic activities exhibited by endophytic fungi from the Brazilian marine red alga Bostrychia tenella (Ceramiales)

Cited by 63 publications

References 69 publications

Molecular profiling and bioactive potential of an endophytic fungus Aspergillus sulphureus isolated from Sida acuta : a medicinal plant

Molecular profiling and bioactive potential of an endophytic fungus Aspergillus sulphureus isolated from Sida acuta : a medicinal plant

Beyond Enzyme Production: Solid State Fermentation (SSF) as an Alternative to Produce Antioxidant Polysaccharides

Marine Algicolous Endophytic Fungi - A Promising Drug Resource of the Era

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