Antibacterial, antidiarrhoeal, and cytotoxic activities of methanol extract and its fractions of Caesalpinia bonducella (L.) Roxb leaves

Billah, Muhammad Mutassim; Islam, Rafikul; Khatun, Hajera; Parvin, Shahnaj; Islam, Ekramul; Islam, SM Anisul; Mia, Akbar Ali

doi:10.1186/1472-6882-13-101

Cited by 47 publications

(31 citation statements)

References 36 publications

(23 reference statements)

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“…The revelation of viable anti-microbial agents, vaccines have diminished the overwhelming effect of irresistible maladies and enhanced personal satisfaction. However, the efficacy of many antimicrobials is being undermined by the development of microbial resistance to existing chemotherapeutic agents [10]. Despite many efforts taken by the government and international organizations as well as advancement in medicines current rate of diarrheal patients is still high at large.…”

Section: Page 2 Ofmentioning

confidence: 99%

Phytochemical Investigation and Anti-Diarrheal Activity of Hydroalcoholic Extract of Fruits of Citrullus colocynthis (L.) Schrad. (Cucurbitaceae)

Pk¹

2017

J Mol Genet Med

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Background: Cucurbitaceae family is one of the best genetically assorted accumulations of restorative plants in the plant kingdom. Previous studies have suggested that Citrullus colocynthis (L.) Schrad. plant parts (root, stem, leaf, fruits, and seeds) have been utilized in the traditional system of medicine. Pharmacological activities reported for this plant include antioxidant activity, antimicrobial activity, anti-diabetic activity, anti-hyperlipidemic activity. The antidiarrheal activity of hydroalcoholic extract of fruits of this plant is reported for the first time in the present study.Objective: To evaluate the anti-diarrheal activity of Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) in experimentally induced diarrhea in Wistar rats. Materials and methods:Hydroalcoholic extract of fruits of Citrullus colocynthis was examined for its acute toxicity on rats, in order to establish the safe doses. Castor oil induced diarrhea model and gastrointestinal motility test using barium sulfate milk were done to assess the antidiarrheal activity of plant extracts. Extract of Citrullus colocynthis at the dose of 50 mg/kg, 100 mg/kg and per se group (100 mg/kg) were used in Wistar rats of either sex. Loperamide (2 mg/kg) was taken as a standard drug in both the models.Results: Phytochemical analysis showed the presence of phenols, alkaloids, terpenoids, flavonoids, saponins, cardiac glycosides, steroids, tannins, and carbohydrates. The acute toxicity studies revealed that extract is relatively safe when given orally; no death was recorded at a dose of 2000 mg/kg. The dose of 100 mg/kg (P<0.001) and 50 mg/kg (P<0.01) of plant fruit extract significantly reduced defecation frequency in 6 h and also increased the latency time which showed similar effects as produced in loperamide treated group. Both doses of fruit extract and loperamide reduced the gastrointestinal motility in Wistar rats significantly (P<0.001). Conclusion:The hydroalcoholic extract of fruits of Citrullus colocynthis showed significant antidiarrheal activity and supports its use as a complementary and alternative medicine for treatment of diarrhea.Although WHO launched Diarrhea Disease Control Program in 1983 to eradicate diarrhea in developing countries included measures like use of traditional remedies, but more than 85% of plants still wait for scientific results in terms of their pharmacological activities [6]. Herbal medicines indicate potential uses in future in light of the fact that the greater part of the plants, their activities, and pharmacological actions have not been investigated totally [7]. The more noteworthy efficiency of plant-origin medicines is because of the antioxidative role which prevents oxidation and provides protection to living beings from harm caused by excessive generation of ROS, lipid peroxidation, DNA strand breaking and protein damage. Prevention of cell oxidative damage, therefore, limits the events of the vast majority of the illnesses. It is the world's third most elevated executioner illness to undernouri...

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Section: Page 2 Ofmentioning

confidence: 99%

Phytochemical Investigation and Anti-Diarrheal Activity of Hydroalcoholic Extract of Fruits of Citrullus colocynthis (L.) Schrad. (Cucurbitaceae)

Pk¹

2017

J Mol Genet Med

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“…It was noticed that the 800 μg/disc concentration shows better activity against all bacteria. Only chloroform extract with all concentrations exhibited better antibacterial activity against all bacteria 8 .…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…As traditionally the use of this plant is made to treat diarrhea, its antidiarrhoeal activity is also supported by the methanol extract of C. bonducella leaves 8 .…”

Section: Antidiarrhoeal Activitymentioning

confidence: 99%

“…In folk core medicines, it is useful in the treatment of paralysis and seed oil of C. bonducella possesses anticonvulsant property 6 . It is reported that it functions as anti-asthmatic, anti-filarial, antioxidant, immunomodulatory, anxiolytic, hypoglycemic activity, antidiarrhoeal, analgesic, adaptogenic, anticonvulsant, antispasmodic, antifeedant, insecticidal and antiamoebic 8 .…”

Section: Morphology Charactersmentioning

confidence: 99%

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Phytochemical and Pharmacological Review of Caesalpinia Bonducella

Kakade¹,

Pingale²,

Chaskar³

2017

Int. Res. J. Pharm.

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Caesalpinia bonducella is classified under the family of Caesalpiniaceae. It is also known as C. bonducella Flem and C. crista Linn. The plant is found in the tropical and the subtropical parts of Asia. It is also found in Andaman, Nicobar islands and in all over India. The plant is a large prickly shrub. The branches are finely gray downy armed with hooked and hard prickles. Leaves, seeds, roots and bark of this plant are useful parts as a medicine. Caesalpinia bonducella (roxb.) shows antipyretic, anti-inflammatory, anthelmintic, antimalarial, antioxidant, antibacterial, antitumor and antidiabetic activities. The Phytochemical screening of C.bonducella shows the existence of different bioactive compounds like sterols,

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“…The extracts were filtered through filter paper, afterwards were dried in vacuum at 40 °C [8] and kept at 4 °C until further uses [9].…”

Section: Preparation Of Extractmentioning

confidence: 99%

Evaluation of antibacterial effect of Cyperus species on typical food-borne pathogens

Lotfabadi¹,

Sani²

2017

JCLM

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Antibacterial, antidiarrhoeal, and cytotoxic activities of methanol extract and its fractions of Caesalpinia bonducella (L.) Roxb leaves

Cited by 47 publications

References 36 publications

Phytochemical Investigation and Anti-Diarrheal Activity of Hydroalcoholic Extract of Fruits of Citrullus colocynthis (L.) Schrad. (Cucurbitaceae)

Phytochemical Investigation and Anti-Diarrheal Activity of Hydroalcoholic Extract of Fruits of Citrullus colocynthis (L.) Schrad. (Cucurbitaceae)

Phytochemical and Pharmacological Review of Caesalpinia Bonducella

Evaluation of antibacterial effect of Cyperus species on typical food-borne pathogens

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