Antibacterial, antibiofilm and antibiotic-potentiating effects of a polyphenol-rich fraction of Dicranopteris linearis (Burm.f.) Underw.

Lai, Choon-Sheen; Ponnusamy, Yasodha; Lim, Gaik-Ling; Ramanathan, Surash

doi:10.1016/j.hermed.2020.100419

Cited by 6 publications

(7 citation statements)

References 19 publications

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“…The increasing incidence of infectious diseases, severe side effects related to the intake of many antibiotics and the development of antibiotic resistance substantiate the growing interest in the identification of new antimicrobial compounds, both natural and synthetic agents [ 131 , 132 , 133 ]. Plant resin has been applied to treat diseases in folk medicine for thousands of years.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Pinus Species as Prospective Reserves of Bioactive Compounds with Potential Use in Functional Food—Current State of Knowledge

Dziedziński

Kobus‐Cisowska

Stachowiak

2021

Plants

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The pine (Pinus L.) is the largest and most heteromorphic plant genus of the pine family (Pinaceae Lindl.), which grows almost exclusively in the northern hemisphere. The demand for plant-based remedies, supplements and functional food is growing worldwide. Although pine-based products are widely available in many parts of the world, they are almost absent as food ingredients. The literature shows the beneficial effects of pine preparations on human health. Despite the wide geographical distribution of pine trees in the natural environment, there are very few data in the literature on the widespread use of pine in food technology. This study aims to present, characterise and evaluate the content of phytochemicals in pine trees, including shoots, bark and conifer needles, as well as to summarise the available data on their health-promoting and functional properties, and the potential of their use in food and the pharmaceutical industry to support health. Various species of pine tree contain different compositions of bioactive compounds. Regardless of the solvent, method, pine species and plant part used, all pine extracts contain a high number of polyphenols. Pine tree extracts exhibit several described biological activities that may be beneficial to human health. The available examples of the application of pine elements in food are promising. The reuse of residual pine elements is still limited compared to its potential. In this case, it is necessary to conduct more research to find and develop new products and applications of pine residues and by-products.

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Section: Antimicrobial Activitymentioning

confidence: 99%

Pinus Species as Prospective Reserves of Bioactive Compounds with Potential Use in Functional Food—Current State of Knowledge

Dziedziński

Kobus‐Cisowska

Stachowiak

2021

Plants

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“…The time–kill curves of 3-carene against P. lundensis were evaluated according to a flat colony-counting method [ 18 ]. 3-Carene solution prepared according to the method in Section 2.2 was added into the bacterial suspension with the concentration of 8–9 log CFU/mL to obtain final concentrations (1 × MIC and 2 × MIC ).…”

Section: Methodsmentioning

confidence: 99%

Antibacterial Mechanism of 3-Carene against the Meat Spoilage Bacterium Pseudomonas lundensis and Its Application in Pork during Refrigerated Storage

Tang

Chen

Zou

et al. 2021

Foods

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Pseudomonas lundensis is the main bacterium responsible for meat spoilage and its control is of great significance. 3-Carene, a natural monoterpene, has been proved to possess antimicrobial activities. This study aimed to investigate the antibacterial activity and mechanism of 3-carene against the meat spoilage bacterium P. lundensis, and explore its application on pork. After 3-carene treatment, cellular structural changes were observed. Cell walls and membranes were destroyed, resulting in the leakage of alkaline phosphatase and cellular contents. The decreased activity of Ca2+-Mg2+-ATPase and Na+-K+-ATPase showed the imbalance of intracellular ions. Subsequently, adenosine triphosphate (ATP) content and oxidative respiratory metabolism characteristics indicated that 3-carene inhibited the metabolism of the tricarboxylic acid cycle in P. lundensis. The results of binding 3-carene with the vital proteins (MurA, OmpW, and AtpD) related to the formation of the cell wall, the composition of the cell membrane, and the synthesis of ATP further suggested that 3-carene possibly affected the normal function of those proteins. In addition, the growth of P. lundensis and increase in pH were inhibited in pork during the 5 days of cold storage after the samples were pre-treated with 3-carene. These results show the anti-P. lundensis activity and mechanism of 3-carene, and its potential use in meat preservation under refrigerated conditions.

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“…Nanotechnology-based approaches, predominantly different types of NPs, metal organic frameworks (MOFs), and other nanomaterials, are also amongst the most studied line of attack to deal with pathogenic biofilms [ 22 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 35 , 36 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ]. Natural plant-based products are being developed to help overcome the problem with multidrug-resistant bacteria, namely plant extracts and isolated compounds, as well as essential oils that contain large amounts of phytochemicals [ 33 , 34 , 37 , 38 , 39 , 40 , 41 , 42 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. In addition, physical approaches (cryogenic freezing, ultrasound), bacteriophages, electrochemical treatments, photodynamic therapy (PDT), combination approaches, and other strategies are also among a few other examples that are being presently implemented [ 26 , 30 , ...…”

Section: Novel Strategies To Control Biofilm-associated Ssismentioning

confidence: 99%

“…Natural plant-based products are being developed to help overcome the problem with multidrug-resistant bacteria, namely plant extracts and isolated compounds, as well as essential oils that contain large amounts of phytochemicals [ 33 , 34 , 37 , 38 , 39 , 40 , 41 , 42 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. In addition, physical approaches (cryogenic freezing, ultrasound), bacteriophages, electrochemical treatments, photodynamic therapy (PDT), combination approaches, and other strategies are also among a few other examples that are being presently implemented [ 26 , 30 , 35 , 36 , 44 , 52 , 54 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ]. For example, the use of antimicrobial PDT, has been extensively studied over the last decade.…”

Section: Novel Strategies To Control Biofilm-associated Ssismentioning

confidence: 99%

“…Also, lectins cause oxidative stress, energetic collapse, and enter fungal cells, thus blocking enzymes involved in the synthesis of wall polymers [ 61 ]. Another study that explored the combined effects of phytochemicals obtained from plant sources and conventional antibiotics was developed by Lai et al [ 62 ]. The antibiotics gentamicin, chloramphenicol, penicillin G, vancomycin, and ampicillin were combined with the polyphenol-rich fraction of Dicranopteris linearis , and its antibacterial and antibiofilm activities were evaluated against S. aureus and P. aeruginosa .…”

Section: Novel Strategies To Control Biofilm-associated Ssismentioning

confidence: 99%

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Biofilms in Surgical Site Infections: Recent Advances and Novel Prevention and Eradication Strategies

2022

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Surgical site infections (SSIs) are common postoperative occurrences due to contamination of the surgical wound or implanted medical devices with community or hospital-acquired microorganisms, as well as other endogenous opportunistic microbes. Despite numerous rules and guidelines applied to prevent these infections, SSI rates are considerably high, constituting a threat to the healthcare system in terms of morbidity, prolonged hospitalization, and death. Approximately 80% of human SSIs, including chronic wound infections, are related to biofilm-forming bacteria. Biofilm-associated SSIs are extremely difficult to treat with conventional antibiotics due to several tolerance mechanisms provided by the multidrug-resistant bacteria, usually arranged as polymicrobial communities. In this review, novel strategies to control, i.e., prevent and eradicate, biofilms in SSIs are presented and discussed, focusing mainly on two attractive approaches: the use of nanotechnology-based composites and natural plant-based products. An overview of new therapeutic agents and strategic approaches to control epidemic multidrug-resistant pathogenic microorganisms, particularly when biofilms are present, is provided alongside other combinatorial approaches as attempts to obtain synergistic effects with conventional antibiotics and restore their efficacy to treat biofilm-mediated SSIs. Some detection and real-time monitoring systems to improve biofilm control strategies and diagnosis of human infections are also discussed.

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Antibacterial, antibiofilm and antibiotic-potentiating effects of a polyphenol-rich fraction of Dicranopteris linearis (Burm.f.) Underw.

Cited by 6 publications

References 19 publications

Pinus Species as Prospective Reserves of Bioactive Compounds with Potential Use in Functional Food—Current State of Knowledge

Pinus Species as Prospective Reserves of Bioactive Compounds with Potential Use in Functional Food—Current State of Knowledge

Antibacterial Mechanism of 3-Carene against the Meat Spoilage Bacterium Pseudomonas lundensis and Its Application in Pork during Refrigerated Storage

Biofilms in Surgical Site Infections: Recent Advances and Novel Prevention and Eradication Strategies

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