Antibacterial and non-cytotoxic effect of nanocomposites based in polyethylene and copper nanoparticles

Tamayo, Laura; Zapata, Paula Andrea; Rabagliati, Franco M.; Azócar, Manuel; Muñoz, Lisa; Zhou, Xiaorong; Thompson, G.E.; Páez, Maritza

doi:10.1007/s10856-015-5475-6

Cited by 19 publications

(11 citation statements)

References 16 publications

(19 reference statements)

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“…Tamayo et al . () demonstrated the antibacterial and noncytotoxic effect of nanocomposites based in polyethylene and copper nanoparticles (PE‐CuNPs nanocomposites) against E. coli isolated from nosocomial infections. Complete inhibition of E. coli was reported after incubation of 12 h with PE‐CuNPs nanocomposites.…”

Section: Role Of Various Nanomaterials For the Management Of Infectionsmentioning

confidence: 99%

“…They concluded that this approach was very efficient to kill the pathogens present in the water and ultimately useful for the management of infections caused due to waterborne pathogens. Tamayo et al (2015) demonstrated the antibacterial and noncytotoxic effect of nanocomposites based in polyethylene and copper nanoparticles (PE-CuNPs nanocomposites) against E. coli isolated from nosocomial infections. Complete inhibition of E. coli was reported after incubation of 12 h with PE-CuNPs nanocomposites.…”

Section: Nanocompositesmentioning

confidence: 99%

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Nanotechnology based anti-infectives to fight microbial intrusions

et al. 2016

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SummaryWith the rise in human population across the globe especially in developing countries, the incidence of microbial infections are increasing with greater pace. On the other hand, available medication and therapies are found to be insufficient for the complete cure of such microbial infections due to the development of resistance against various antibiotics. Therefore, to cope up the menace of microbial infections and drug resistance, there is demand for new and compelling technology, which has the ability to impede these problems. Many research groups worldwide are finding a ray of hope in nanomaterials owing to their unique properties. In the present review we have discussed the reasons behind the development of new materials based on nanotechnology. It is mainly focused on pioneering studies on application of nanomaterials like carbon nanotube, fullerene, dendrimers, nanocomposite and metal nanoparticles in combating dreadful pathogens. Moreover, the concerns about their toxicity have also been discussed.

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Section: Role Of Various Nanomaterials For the Management Of Infectionsmentioning

confidence: 99%

Section: Nanocompositesmentioning

confidence: 99%

Nanotechnology based anti-infectives to fight microbial intrusions

et al. 2016

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“…2,3 Copper nanoparticles (Cu NPs), one of the manufactured NPs, are now industrially produced and available commercially. Recently, Cu NP has shown great promise as an antibacterial material [4][5][6][7] and even been used as intrauterine contraceptive device (IUD). [8][9][10][11][12][13][14] Recently, a new type of nano-Cu IUD was invented by However, numerous studies have unequivocally indicated that exposure to Cu NPs can result in adverse effects in vivo and in vitro.…”

Section: Introductionmentioning

confidence: 99%

Copper nanoparticle-induced ovarian injury, follicular atresia, apoptosis, and gene expression alterations in female rats

Yang¹,

Hu²,

Rao³

et al. 2017

IJN

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Numerous studies have reported the accumulation of copper nanoparticles (Cu NPs) in organs and the corresponding damage, although whether Cu NPs can be translocated to the ovaries and their ovarian toxicity are still unknown. In this study, three groups of female rats were injected with 3.12, 6.25, or 12.5 mg/kg Cu NPs for 14 consecutive days. The pathological changes, hormone levels, apoptosis and apoptotic proteins, oxidative stress, and gene expression characteristics in the ovaries were then investigated. The results demonstrated that the Cu NPs exhibited obvious accumulation in the rat ovaries, leading to ovarian injury, an imbalance of sex hormones, and ovarian cell apoptosis. Cu NP exposure activated caspase 3, caspase 8, caspase 9, and tBid, decreased the protein levels of Bcl-2, increased the expression levels of the proteins Bax and cytochrome c , and promoted malondialdehyde (MDA) accumulation and superoxide dismutase (SOD) reduction. Furthermore, gene microarray analysis showed that Cu NPs (12.5 mg/kg/d) caused 321 differentially expressed genes. Of these, 180 and 141 genes were upregulated and downregulated, respectively. Hsd17b1 , Hsd3b1 , Hsd3b6 , and Hsd3b were involved in steroid and hormone metabolism, whereas Mt3 and Cebpb were associated with apoptosis. Overall, these findings provide strong evidence that Cu NPs trigger both intrinsic and extrinsic apoptotic pathways and regulate key ovarian genes in oxidative stress-mediated ovarian dysfunction.

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“…Usually, antibacterial agents used in plastics can be classified into two kinds: inorganic antibacterial agents and organic antibacterial agents. Inorganic antibacterial agents are some metals such as copper, silver, zinc, and their oxides . For example, Chen prepared ABS/Ag composite through injection molding process.…”

Section: Introductionmentioning

confidence: 99%

Preparation and properties of antibacterial ABS plastics based on polymeric quaternary phosphonium salts antibacterial agents

Zeng

Liu

2019

Polymers for Advanced Techs

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Antibacterial acrylonitrile‐butadiene‐styrene (ABS) plastics were prepared by adding polymeric quaternary phosphonium salts as antibacterial agents through a double screw extruder. The novel polymeric quaternary phosphonium salts (PBrMAP‐n) with alkyl chain length ranging from 3 to 11 were synthesized, and their chemical structures were confirmed by Nuclear magnetic resonance hydrogen spectroscopy (1H‐NMR) and Fourier transform infrared spectroscopy (FT‐IR) spectra. The thermogravimetric analysis (TGA) results showed that all of the antibacterial agents had good thermal stability. The influence of addition amount as well as the alkyl chain length on mechanical properties and antibacterial properties was investigated. Compared with the pure ABS, all of PBrMAP‐n containing specimens had comparable tensile strength and flexural properties but reduced impact strength. Only samples with 10 wt% of PBrMAP‐11 exhibited more than 90% antibacterial efficiency against Escherichia coli and Staphylococcus aureus.

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Antibacterial and non-cytotoxic effect of nanocomposites based in polyethylene and copper nanoparticles

Cited by 19 publications

References 16 publications

Nanotechnology based anti-infectives to fight microbial intrusions

Nanotechnology based anti-infectives to fight microbial intrusions

Copper nanoparticle-induced ovarian injury, follicular atresia, apoptosis, and gene expression alterations in female rats

Preparation and properties of antibacterial ABS plastics based on polymeric quaternary phosphonium salts antibacterial agents

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