Antibacterial and mechanical properties of arginine-containing glass ionomer cements

L-Arginine-containing mesoporous silica nanoparticles embedded in dental adhesive for targeting cariogenic dental biofilm

“…In 2017, Geraldeli et al [18], proposed the inclusion of L-arginine in a concentration of 7% in a dental adhesive reporting that its release endowed a signi cant antibacterial effect against S. mutans that was speci c for this cariogenic bacterium. This behaviour as bio lm modi er was also observed when 4% L-arginine was added to a glass ionomer cement [11], and a commercial orthodontic resin cement [23]. The same letter read vertically indicates differences that were not statistically signi cant according to the Games-Howell test.…”

“…The inclusion of a natural amino acid, as L-arginine, instead of other antibacterial agents, limits the possibility of antimicrobial resistance in pathogens [61] while promotes the growth of healthy bacteria that may maintain or restore the homeostasis in bio lms adjacent to resin composite restorations [11]. This could inhibit or limit the progression of secondary caries lesions.…”

“…One of the strategies to prevent the development of secondary caries is to introduce bio lm modi ers, mainly in dental adhesives, since they would inhibit microbial populations with cariogenic action and enhance the growth of pro-healthy bacteria [11][12][13][14][15][16][17][18][19][20][21][22]. However, the disadvantage of the free addition of antibacterial agents or drugs into resin composite is the short duration of the antibacterial effect due to the absence of restrictions to be released, as well as the possible impairment of the mechanical and adhesive properties [23,24].…”

“…Moreover, different studies have demonstrated that arginine inhibits the growth of pathogenic bacteria, such as S. mutans [36,40,41] and its incorporation in uorinated toothpaste has shown to clinically reduce the incidence of dental caries [42]. Accordingly, this oral prebiotic has been also included in its free form in uoride varnishes [43], glass ionomer cements [11], orthodontic light-cured resin cements [23] and dental adhesives [18].…”

Concentration-Dependent Multi-Potentiality of L-Arginine: Antimicrobial Effect, Hydroxyapatite Stability, and MMPs Inhibition

“…The remineralisation potential, enamel F uptake, and antimicrobial effect of F in the presence of arg were explored by our previous studies [30][31][32][33][34]. Although studies have investigated the effect of arg on the biofilms and substrates (i.e., HA discs, enamel, etc.…”