Antibacterial and Immunomodulating Activity of Silver Nanoparticles on Mice Experimental Tuberculosis Model

Kalmantaeva, O. V.; Фирстова, В В; Grishchenko, N. S.; Rudnitskaya, Tatiana I.; Потапов, В. Д.; Ignatov, Sergei G.

doi:10.1134/s0003683820020088

Cited by 15 publications

(7 citation statements)

References 21 publications

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“…Silver nanoparticles' applications are extensive, from food processing, cosmetics, home cleaning, catalytic and garment production to medicinal applications (Bansod et al 2015 ; Benn et al 2010 ; Zhu et al 2022 ). Medicinally AgNPs have been used for the treatment of diseases such as cancer, HIV, diabetes, malaria and tuberculosis (Casañas Pimentel et al 2016 ; Kalmantaeva et al 2020 ; Kasithevar et al 2017 ; Muthukumaran et al 2015 ). Green chemistry-based strategies have been addressed in the synthesis of nanoparticles in recent years, among the various chemical and physical ways of nanoparticle synthesis (Noah and Ndangili 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of silver nanoparticles using Eupatorium adenophorum leaf extract: characterizations, antioxidant, antibacterial and photocatalytic activities

et al. 2023

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The green synthesis of metallic nanoparticles has tremendous impacts in various fields as found in recent years due to their low cost, easy and environmentally friendly synthesis. In this article, we report a simple and eco-friendly method for the synthesis of silver nanoparticles (AgNPs) using an aqueous Eupatorium adenophorum ( E. adenophorum ) leaf extract as a bioreductant. Interestingly, Fourier transform infrared (FTIR) spectroscopy analysis established that the E. adenophorum extract not only served as a bioreductant but also acted as a capping agent to stabilize the nanoparticles by functionalizing the surfaces. Various characterization techniques were adopted, such as X-ray powder diffraction (XRD), FTIR, ultraviolet–visible absorption (UV–Vis) spectroscopy, dynamic light scattering, scanning electron microscopy and energy-dispersive X-ray spectroscopy (EDX) to analyze the biosynthesized AgNPs. Biosynthesized nanoparticles were also explored for antioxidant, antibacterial and photocatalytic activities. The AgNPs showed improved free radical scavenging activity (IC 50 48.96 ± 0.84 µg/mL) and bacterial inhibitory effects against both gram-positive ( Staphylococcus aureus ; 64.5 µg/mL) and gram-negative ( Escherichia coli ; 82.5 µg/mL) bacteria. Photocatalytic investigation showed AgNPs were effective at degrading rhodamine dye (78.69% in 90 min) when exposed to sunlight. These findings collectively suggest that E. adenophorum AgNPs were successfully prepared without the involvement of any hazardous chemical and it may be an effective antibacterial, antioxidant and promising agent for the removal of hazardous dye from waste water produced by industrial dyeing processes.

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Section: Introductionmentioning

confidence: 99%

Green synthesis of silver nanoparticles using Eupatorium adenophorum leaf extract: characterizations, antioxidant, antibacterial and photocatalytic activities

et al. 2023

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“…Among them, silver and gold nanoparticles (AgNPs and AuNPs) are considered as important and effective because of their distinctive physical, chemical and biological characteristics [ 84 ]. In former times, silver was considered as an essential antimicrobial agent in treatment of various infectious entities [ 85 ]. So, both of these AgNPs and AuNPs may exhibit antimycobacterial effect alone or by being conjugated with various stabilizing agents/antibiotics/peptides/polymers to show a combinatorial effect which will help in the treatment of MDR/XDR TB [ 84 ].…”

Section: Nanotechnology Based Strategies To Treat Tuberculosismentioning

confidence: 99%

“…The alterations in the number of colony forming units (CFUs) observed after the treatment with these nanoparticles were in agreement with the results of fluorescence experiment [ 86 ]. An independent study by Ignatov and coworkers revealed that the growth of M. tuberculosis H37Rv was inhibited in the in vitro treatment of 0.1–50 μg/ml polyvinylpyrrolidone (PVP) stabilized single dispersed silver nanoparticles (SNPs-PVP) [ 85 ]. The maximum inhibition (by two times) was observed in presence of 50 µg/ml SNPs-PVP.…”

Section: Nanotechnology Based Strategies To Treat Tuberculosismentioning

confidence: 99%

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Impact of nanoparticles on amyloid β-induced Alzheimer’s disease, tuberculosis, leprosy and cancer: a systematic review

et al. 2023

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Nanotechnology is an interdisciplinary domain of science, technology and engineering that deals with nano-sized materials/particles. Usually, the size of nanoparticles lies between 1-100 nm. Due to their small size and large surface area-to-volume ratio, nanoparticles exhibit high reactivity, greater stability and adsorption capacity. These important physicochemical properties attract scientific community to utilize them in biomedical field. Various types of nanoparticles (inorganic and organic) have broad applications in medical field ranging from imaging to gene therapy. These are also effective drug carriers. In recent times, nanoparticles are utilized to circumvent different treatment limitations. For example, the ability of nanoparticles to cross the blood brain barrier and having a certain degree of specificity towards amyloid deposits, makes themselves important candidates for the treatment of Alzheimer’s disease. Furthermore, nanotechnology has been used extensively to overcome several pertinent issues like drug-resistance phenomenon, side effects of conventional drugs and targeted drug delivery issue in leprosy, tuberculosis and cancer. Thus, in this review, the application of different nanoparticles for the treatment of these four important diseases (Alzheimer’s disease, tuberculosis, leprosy and cancer) as well as for the effective delivery of drugs used in these diseases has been presented systematically. Although nanoformulations have many advantages over traditional therapeutics for treating these diseases, nanotoxicity is a major concern which has been discussed subsequently. Lastly, we have presented the promising future prospective of nanoparticles as alternative therapeutics. In that section, we have discussed about the futuristic approach(es) that could provide promising candidate(s) for the treatment of these four diseases.

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“…The discovery of antibiotics in the 1940s interrupted the use of silver against microbial infections. However, the emergence of antibiotic-resistant bacteria within recent decades has revived interest in the antibacterial and antiviral properties of silver [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Aerosol Inhalation Delivery of Ag Nanoparticles in Mice: Pharmacokinetics and Antibacterial Action

Valiulin,

Onischuk,

Pyryaeva

et al. 2023

Antibiotics

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The aerosol inhalation delivery of composite particles consisting of Ag nanoparticles enveloped by polyvinylpyrrolidone was investigated in experiments with mice. An ultrasonic nebulizing system was created for the generation of aerosols with a mean diameter and mass concentration of 700 ± 50 nm and 65 ± 5 mg/m3, respectively. The mass fraction of Ag in the composite particles was α = 0.061. The aerosol delivery was performed in a whole-body chamber with an exposition time of 20 min. Pharmacokinetic measurements were taken and the silver concentrations in the blood and lungs of the mice were measured as a function of time after exposition by means of electrothermal (graphite furnace) atomic absorption spectrometry. The inhalation dose and other pharmacokinetic parameters were determined. The antibacterial effect of aerosolized silver was assessed for mice infected with Klebsiella pneumoniae 82 and Staphylococcus aureus ATCC 25953. The survival rate of the infected mice after the aerosol exposure demonstrated the high antibacterial efficiency of Ag nanoparticles after inhalation delivery.

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Antibacterial and Immunomodulating Activity of Silver Nanoparticles on Mice Experimental Tuberculosis Model

Cited by 15 publications

References 21 publications

Green synthesis of silver nanoparticles using Eupatorium adenophorum leaf extract: characterizations, antioxidant, antibacterial and photocatalytic activities

Green synthesis of silver nanoparticles using Eupatorium adenophorum leaf extract: characterizations, antioxidant, antibacterial and photocatalytic activities

Impact of nanoparticles on amyloid β-induced Alzheimer’s disease, tuberculosis, leprosy and cancer: a systematic review

Aerosol Inhalation Delivery of Ag Nanoparticles in Mice: Pharmacokinetics and Antibacterial Action

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