Antibacterial and conductive injectable hydrogels based on quaternized chitosan-graft-polyaniline/oxidized dextran for tissue engineering

Zhao, Xin; Li, Peng; Guo, Baolin; Peter, X.

doi:10.1016/j.actbio.2015.08.006

Cited by 464 publications

(223 citation statements)

References 82 publications

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“…Figure 4 reveals that the conductivity of hydrogel results in better cellular activity, such as proliferation. Conductive substrate facilitates the intracellular biosignal transition and ameliorates cell -cell interaction (23). However, increasing the PANI content resulted in toxicity and reduced cell viability; therefore, the optimum value of the conductive part should be determined in a conductive substrate.…”

Section: Discussionmentioning

confidence: 99%

Bio - Conductive Scaffold Based on Agarose - Polyaniline for Tissue Engineering

et al. 2017

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Architecting novel scaffold for tissue engineering has attracted significant attention. Biomimic scaffolds can enhance cellular activity and tissue regeneration. Conductive scaffold exhibited ameliorated regeneration and tissue repair. In this research, conductive hydrogel based on agarose/polyaniline was synthesized to evaluate hydrogel performance as a novel candidate for tissue engineering. Agarose/polyaniline was synthesized using in -situ oxidative polymerization to achieve conductive hydrogel. Fourier Transform Infrared Spectroscopy (FTIR) was utilized for characterization of the hydrogel. Cyclic voltammetry and conductivity measurement were applied for determining the electro -activity and hydrogel conductivity. Hydrogel conductivity was around 10 to 4 S/cm and exhibited two redox peaks attributed to electroactive transitional state around 0.8 and 0.6. Polyaniline addition to hydrogel decreased the hydrogel swelling capacity because of the hydrophobic nature of polyaniline from 60% to 30%. Cell viability test revealed that the conductive substrate enhanced cellular proliferation. Agarose/polyaniline can be widely utilized in tissue engineering because of adjustable swelling behavior and conductivity, which can affect cellular activity and regeneration.

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Section: Discussionmentioning

confidence: 99%

Bio - Conductive Scaffold Based on Agarose - Polyaniline for Tissue Engineering

et al. 2017

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“…Fibroblast cells demonstrate good adhesion and growth on the hydrogel surfaces. Many efforts have been devoted to the development of EHs as 3D scaffold of tissues (Mawad et al, ; Sasaki et al, ; Zarrintaj et al, ; X. Zhao, Li, Guo, & Ma, ), which have great promise for use as conducting substrates for the growth of electro‐responsive cells in tissue engineering. A thorough review of conducting polymers for tissue engineering application has been published by Ma, where bone tissue engineering, muscle tissue engineering, nerve tissue engineering, cardiac tissue engineering, and wound healing application are discussed in detail (B. Guo & Ma, ).…”

Section: Ehs For Biomedical Applicationsmentioning

confidence: 99%

Electroconductive hydrogels for biomedical applications

Han

Zhang

2019

WIREs Nanomed Nanobiotechnol

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Electroconductive hydrogels (EHs), combining both the biomimetic features of hydrogels and the electrochemical properties of conductive polymers and carbon‐based materials, have received immense considerations over the past decade. The three‐dimensional porous structure, hydrophilic properties, and regulatable chemical and physical properties of EH resemble the extracellular matrix in tissues, enable EHs a good matrix for cell growth, proliferation, and migration. Different from nonconductive hydrogels, EHs possess high electrical conductivity and electrochemical redox properties, which can be utilized to detect electric signals generated in biological systems, and also to supply electrical stimulation to regulate the activity and function of cells and tissues. Hence, this article provides a summary of the new development of EH for biomedical applications in the decade. We give a brief introduction of the design and synthesis of EHs, as well as current applications of EHs in biomedical fields, including cell culture, tissue engineering, drug delivery and controlled release, biosensors, and implantable bioelectronics. The development trends and challenges of EHs for biomedical applications are also discussed. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Diagnostic Tools > Biosensing Therapeutic Approaches and Drug Discovery > Emerging Technologies

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“…It proved to have antibacterial properties and stimulated C2C12 myoblast formation. Rabbit adipose tissue-derived MSC showed good survival and proliferation rates on the scaffolds [85]. Very recently, scaffolds based on chitosan and gelatin have been synthesized for use with dental pulp stem cell (DPSC) differentiation and alveolar bone regeneration.…”

Section: Polysaccharide Scaffoldsmentioning

confidence: 99%

Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

et al. 2019

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Bone tissue engineering is an ever-changing, rapidly evolving, and highly interdisciplinary field of study, where scientists try to mimic natural bone structure as closely as possible in order to facilitate bone healing. New insights from cell biology, specifically from mesenchymal stem cell differentiation and signaling, lead to new approaches in bone regeneration. Novel scaffold and drug release materials based on polysaccharides gain increasing attention due to their wide availability and good biocompatibility to be used as hydrogels and/or hybrid components for drug release and tissue engineering. This article reviews the current state of the art, recent developments, and future perspectives in polysaccharide-based systems used for bone regeneration.

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Antibacterial and conductive injectable hydrogels based on quaternized chitosan-graft-polyaniline/oxidized dextran for tissue engineering

Cited by 464 publications

References 82 publications

Bio - Conductive Scaffold Based on Agarose - Polyaniline for Tissue Engineering

Bio - Conductive Scaffold Based on Agarose - Polyaniline for Tissue Engineering

Electroconductive hydrogels for biomedical applications

Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

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