Antibacterial and bioactive properties of stabilized silver on titanium with a nanostructured surface for dental applications

Kim, Sung-Won; Park, Cheonil; Cheon, Kwang-Hee; Jung, Hyun‐Do; Song, Juha; Kim, Hyoun‐Ee; Jang, Tae‐Sik

doi:10.1016/j.apsusc.2018.04.270

Cited by 48 publications

(23 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PLGA(Ag-Fe3O4)-coated dental implants [175] Sm 7 inhibited bacteria adherence Ag nanoparticles coated on titanium [179] E coli, Sa showed antibacterial effect and sustained release for 7 days Antibiotics doxycycline-coated abutment surfaces [180] Se 8 inhibited the bacterial growth; showed sustained release for least 2 weeks Tetracycline-containing fibers coated titanium implant [171] Pg, Fn 9 ,Pi 10 , Aa showed inhibition of biofilm and kept releasing for 3 days silica-gentamycin coated titanium implant [170] Sa showed antibacterial effect and sustained release for 14 days Tetracycline loaded nanofibers coated titanium implant [43] Aa, Fn, Pg, Pi Showed anti-bacterial effect Tetracycline loaded titanium [181] Pg showed antibacterial efficiency and sustained release for 15 days Cationic antibacterial agents chlorhexidine hexametaphosphate nanoparticles coated titanium [182] Sg demonstrated antibacterial effect and sustained release of soluble chlorhexidine for 99 days The PIXIT implant containing polysiloxane oligomers and chlorhexidine gluconate [183] Clinic trail controlled bacterial adhesion; reduced the bacterial species involved with long-term failure of dental implant Dimethylaminododecyl Methacrylate(DMADDM) coated dental implant [172] saliva-derived biofilm inhibited biofilm growth and regulated microecosystem Bioactive antibacterial agents Chitosan/P-HAP bi-layers coated titanium implant [184] Sg Demonstrated an appropriate mouse pre-osteoblastic cell response, and significant anti-bacterial activity * The bacterial model were showed in abbreviated form: 1 Such kinds of dual-functional DDS not only show antibacterial effects without affecting biocompatibility, but also help promote bone regeneration, which has excellent application potential. However, long-term drug release and multifunctional dental implant research are still limited.…”

Section: Coating Type Anti-bacterial Experiments Model * Resultsmentioning

confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

View full text Add to dashboard Cite

The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.Molecules 2020, 25, 516 2 of 29 problems. For example, systemic antibiotics such as tetracycline, beta-lactam antibiotics, nitroimidazoles have been used, especially in cases of periodontal diseases and peri-implantitis [12]. However, systemic antibiotics could cause problems like drug resistance, dysbacteriosis, and systemic side effects [13,14]. The antibacterial effect is also limited as very little could arrive at the oral lesion area after systemic circulation [15][16][17]. Fluoride in drinking water has been used for the prevention of dental caries but might cause excessive intake, leading to fluorosis [18]. Therefore, local drug therapy is now more considered for oral infectious diseases [19,20]. However, the conventional forms of local therapy, like drug suspension or rinse of anti-infection agents, could be easily washed off and thus could not last long in the oral cavity. Complex local lesions like deep periodontal pockets and teeth fissure are also difficult to reach. In order to improve the effect of prophylaxis and treatment, more precise targeting therapy is quite essential [21,22]. Therefore, drug delivery systems have drawn great attention in recent decades in oral infectious diseases. Drug delivery systems (DDS) are devices that can transport and release the therapeutic agents or bioactive substances to certain sites at certain rates in vivo [23,24], usually composed of the carriers and associated therapeutics [25]. They have been widely explored in biomedical research. With local drug administration and controlled drug release, DDS could provide higher curative efficiency and fewer side effects [23,26,27]. With all these advantages, DDS has been reported w...

show abstract

Section: Coating Type Anti-bacterial Experiments Model * Resultsmentioning

confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The antimicrobial assays were conducted based on Kim et al 20 with some modifications. Cultures of Escherichia coli, and Staphylococcus aureus, Gram-negative and Gram-positive bacteria respectively were grown in Luria-Bertani (LB) broth (Tryptone 10 g/L, Yeast extract 5 g/L, NaCl 10 g/L pH 7.0) at 37 o C and 120 rpm to reach 10 7 CFU/mL.…”

Section: Antimicrobial Assaysmentioning

confidence: 99%

Plasma-Assisted Silver Deposition on Titanium Surface: Biocompatibility and Bactericidal Effect

et al. 2021

View full text Add to dashboard Cite

Dental implants are especially susceptible to bacterial adhesion and so microbial contamination. Several techniques have been explored in order to obtain implant surfaces enriched with silver (Ag). The main challenge is to obtain a bactericidal effect keeping the surface biocompatible. In this regard plasma-assisted deposition is a very attractive technique due to its versatility and low environmental impact. Thus, the present work aimed at evaluating the chemical stability, antibacterial activity, and biocompatibility of a commercially pure titanium (cp-Ti) surface containing very low amounts of plasmadeposited Ag. Ag deposition obtained by 10 minutes sputtering was able to promote antibacterial action (around 30%) on a clearly cytocompatible Ti/Ag surface with no apparent impact on biocompatibility. Taken together these results indicate that the proposed deposition process has a great potential for dental implant application with the advantage of using very small amounts of silver to achieve efficacy.

show abstract

“…Thus, an emerging research area is the development of anti-bacterial implant materials. For example, Kim et al [69] indicated the concentration of implanted silver and the topography of the surface determine the effect on the action against micro-organisms. As is shown in Figure 9, hierarchical titanium with silver nanoparticles surface (Figure 8e There are numerous elements, such as zinc (Zn), silver (Ag), fluorine (F), tantalum (Ta), calcium (Ca), chlorine (Cl),nitrogen (N), iodine (I), copper (Cu) and carbon (C), that might be injected into titanium alloys surface by PIII of the corresponding ions [66][67][68].…”

Section: Ion Implantationmentioning

confidence: 99%

“…Thus, an emerging research area is the development of anti-bacterial implant materials. For example, Kim et al [69] indicated the concentration of implanted silver and the topography of the surface determine the effect on the action against microorganisms. As is shown in Figure 9, hierarchical titanium with silver nanoparticles surface ( Figure 8e,f) significantly promoted cellular adhesion and proliferation while have excellent antimicrobial ability.…”

Section: Ion Implantationmentioning

confidence: 99%

Surface Modification of Biomedical Titanium Alloy: Micromorphology, Microstructure Evolution and Biomedical Applications

2019

View full text Add to dashboard Cite

With the increasing demand for bone implant therapy, titanium alloy has been widely used in the biomedical field. However, various potential applications of titanium alloy implants are easily hampered by their biological inertia. In fact, the interaction of the implant with tissue is critical to the success of the implant. Thus, the implant surface is modified before implantation frequently, which can not only improve the mechanical properties of the implant, but also polish up bioactivity and osseoconductivity on a cellular level. This paper aims at reviewing titanium surface modification techniques for biomedical applications. Additionally, several other significant aspects are described in detail in this article, for example, micromorphology, microstructure evolution that determines mechanical properties, as well as a number of issues concerning about practical application of biomedical implants.

show abstract

Antibacterial and bioactive properties of stabilized silver on titanium with a nanostructured surface for dental applications

Cited by 48 publications

References 41 publications

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Plasma-Assisted Silver Deposition on Titanium Surface: Biocompatibility and Bactericidal Effect

Surface Modification of Biomedical Titanium Alloy: Micromorphology, Microstructure Evolution and Biomedical Applications

Contact Info

Product

Resources

About