Antibacterial and Bacterium Adsorbing Macromolecules

Tashiro, Tatsuo

doi:10.1002/1439-2054(20010201)286:2<63::aid-mame63>3.0.co;2-h

Cited by 318 publications

(110 citation statements)

References 66 publications

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“…[5] Polymers containing quaternary nitrogen functionalities have been commonly used as biocidal agents. [6][7][8][9][10][11][12][13][14][15] A number of polymeric disinfectants based on quaternary pyridinium groups, either in the backbone or as pendant groups, have been prepared, which show good activity against bacteria. Recently, Gao and coworkers synthesized random copolymers of acrylamide and vinyl pyridine of varying MWs and pyridine content, which were subsequently quaternized with dimethyl sulfate.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Hemolytic Activities of Quaternary Pyridinium Functionalized Polynorbornenes

Eren

Som

Rennie

et al. 2008

Macro Chemistry & Physics

146

163

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In this study, amphiphilic polyoxanorbornene with different quaternary alkyl pyridinium side chains were synthesized. The biological efficiencies of these polymers, with various alkyl substituents, were determined by bacterial growth inhibition assays and hemolytic activity (HC 50 ) against human red blood cells (RBCs) to provide selectivity of these polymers for bacterial over mammalian cells. A series of polymers with different alkyl substituents (ethyl, butyl, hexyl, octyl, decyl and phenylethyl) and two different molecular weights (3 and 10 kDa) were prepared. The impact of alkyl chain length divided the biological activity into two different cases: those with an alkyl substituent containing four or fewer carbons had a minimum inhibitory concentration (MIC) of 200 mg Á mL À1 and a HC 50 greater than 1 650 mg Á mL À1 , while those with six or more carbons had lower MICs 12.5 mg Á mL À1 and HC 50 250 mg Á mL À1 . Using MSI-78, the potent Magainin derivative which has an MIC ¼ 12.0 mg Á mL À1 and HC 50 ¼ 120 mg Á mL À1 , as a comparison, the polymers with alkyl substituents C 4 (four carbons) were not very potent, but did show selectivity values greater than or equal to MSI-78. In contrast, those with alkyl substituents !C 6 were as potent, or more potent, than MSI-78 and in three specific cases demonstrated selectivity values similar to, or better than, MSI-78. To understand if these polymers were membrane active, polymer induced lipid membrane disruption activities were evaluated by dye leakage experiments. Lipid composition and polymer hydrophobicity were found to be important factors for dye release.

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Section: Introductionmentioning

confidence: 99%

Antibacterial and Hemolytic Activities of Quaternary Pyridinium Functionalized Polynorbornenes

Eren

Som

Rennie

et al. 2008

Macro Chemistry & Physics

146

163

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“…This often leads to objectionable odor, dermal infection, product deterioration, allergic responses and other related diseases (Singh et al 2005;Thiry 2001). Hence, a wide range of antimicrobial agents have been applied to textiles, including silver based materials (Klueh et al 2000;Yuranova et al 2003), halamine compounds (Sun and Sun 2003), quaternary ammonium (Lin et al 2003;Tashiro 2001), and phosphonium polymers (Tashiro 2001) to produce antimicrobial clothing or sanitary textile products. On the other hand, natural dyes are recently being revived and gaining popularity again with increasing environment protection awareness and concern for the medicinal properties (Singh et al 2005;Jeong et al 2006;Yi and Yoo 2010).…”

Section: Introductionmentioning

confidence: 99%

Preparation and properties of multi-functionalized cotton fabrics treated by extracts of gromwell and gallnut

et al. 2011

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Extracts from the root of Lithospermum erythrorhizon (gromwell) have been used for many centuries as a natural red dye and crude drugs with excellent performance for wound healing. In particular, shikonin a major constituent of the gromwell colorant is reported to possess antibacterial, antioxidant, anti-inflammatory, antitumor activities, etc. Therefore, we tried to manufacture antimicrobial and antioxidant cotton fabrics for biocompatible clothing materials using the natural stuff and environmentally friendly process. In this study, cotton fabrics were dyed with the colorant extracted from the root of gromwell, and their properties were closely investigated. Consequently, we discovered that the cotton fabrics dyed with the extracts from the root of gromwell showed excellent antioxidant performance as well as antibacterial ability. Also, the functionalities and color fastness were improved by gallnut mordanting and cationization of the cotton fabrics.

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“…Well-defined ionenes enable a variety of potential technologies; however, most emphasis is placed on biomedical technologies, such as model gene transfection agents, [12][13][14][15] antimicrobials, [16][17][18][19][20] and cancer therapeutics. [21] Herein, the synthesis of 12,12-ammonium ionenes possessing UV-reactive end groups is described.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 12,12‐Ammonium Ionenes with Functionality for Chain Extension and Cross‐Linking via UV Irradiation

Williams

Barta

Ramirez

et al. 2009

Macro Chemistry & Physics

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A novel synthetic methodology for preparing chain‐extended and cross‐linked ionenes using UV irradiation is described. 12,12‐Ammonium ionenes were functionalized with either cinnamate or styrenic functionality at the chain ends and were subsequently exposed to UV irradiation. In addition, a novel copolymer (poly(cinDMPC‐co‐bocDMPC)) was mixed with the cinnamate‐functionalized 12,12‐ammonium ionene to prepare photo‐cross‐linked networks. The UV irradiation process was monitored via UV–Vis spectroscopy after each exposure. The chain‐extended 12,12‐ammonium ionene possessed superior tensile properties compared to the original 12,12‐ammonium ionene. Successful cross‐linking was confirmed with solubility testing of the thin films in methanol. The results indicated that photo‐cross‐linked 12,12‐ammonium ionenes offer potential in membrane technology applications.

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Antibacterial and Bacterium Adsorbing Macromolecules

Cited by 318 publications

References 66 publications

Antibacterial and Hemolytic Activities of Quaternary Pyridinium Functionalized Polynorbornenes

Antibacterial and Hemolytic Activities of Quaternary Pyridinium Functionalized Polynorbornenes

Preparation and properties of multi-functionalized cotton fabrics treated by extracts of gromwell and gallnut

Synthesis of 12,12‐Ammonium Ionenes with Functionality for Chain Extension and Cross‐Linking via UV Irradiation

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