Antibacterial and antiproliferation activity of green synthesized nanoparticles from rhizome extract of Alpinia galangal (L.) Wild

Raveesha, H. R.; Bharath, H.L.; Vasudha, D.R.; Sushma, B; Pratibha, S.; Dhananjaya, N.

doi:10.1016/j.inoche.2021.108854

Cited by 8 publications

(11 citation statements)

References 26 publications

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“…Furthermore, owing to their magnetic property, these NPs can be further enhanced by conjugating them with other therapeutic drugs. Other reported studies of various green synthesized IONPs with anticancer properties include [ 137 , 138 , 139 , 140 , 141 , 142 ].…”

Section: Metal Nanoparticles In Cancer Treatmentmentioning

confidence: 99%

Current Trends and Prospects for Application of Green Synthesized Metal Nanoparticles in Cancer and COVID-19 Therapies

Mbatha

Akinyelu

Chukwuma

et al. 2023

Viruses

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Cancer and COVID-19 have been deemed as world health concerns due to the millions of lives that they have claimed over the years. Extensive efforts have been made to develop sophisticated, site-specific, and safe strategies that can effectively diagnose, prevent, manage, and treat these diseases. These strategies involve the implementation of metal nanoparticles and metal oxides such as gold, silver, iron oxide, titanium oxide, zinc oxide, and copper oxide, formulated through nanotechnology as alternative anticancer or antiviral therapeutics or drug delivery systems. This review provides a perspective on metal nanoparticles and their potential application in cancer and COVID-19 treatments. The data of published studies were critically analysed to expose the potential therapeutic relevance of green synthesized metal nanoparticles in cancer and COVID-19. Although various research reports highlight the great potential of metal and metal oxide nanoparticles as alternative nanotherapeutics, issues of nanotoxicity, complex methods of preparation, biodegradability, and clearance are lingering challenges for the successful clinical application of the NPs. Thus, future innovations include fabricating metal nanoparticles with eco-friendly materials, tailor making them with optimal therapeutics for specific disease targeting, and in vitro and in vivo evaluation of safety, therapeutic efficiency, pharmacokinetics, and biodistribution.

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Section: Metal Nanoparticles In Cancer Treatmentmentioning

confidence: 99%

Current Trends and Prospects for Application of Green Synthesized Metal Nanoparticles in Cancer and COVID-19 Therapies

Mbatha

Akinyelu

Chukwuma

et al. 2023

Viruses

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“…This effect is achieved by stimulating apoptosis and lowering drug resistance genes (MAPK1 and MDR1). Moreover, A. galangal enhances p53 expression and apoptosis (Ahlina et al 2020) and acts as an antiproliferative agent by triggering S phase arrest in the cell cycle (Raveesha et al 2021). A. galangal boosted the lethal impacts of cytotoxic T-cells by reducing the abundance of human triple-negative cancerous cells (Alif et al 2021).…”

Section: Alpinia Galangamentioning

confidence: 99%

The use of medicinal plants for combating breast cancer: A comprehensive review

Alsubhi

2023

J Exp Bio & Ag Sci

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Breast carcinoma is a common illness among females. Various therapies, including hormone therapy, surgery, radiotherapy, chemotherapy, and targeted treatment, have been available to treat existing breast cancer. These therapies can potentially halt the development and spread of cancer, especially if the disease is at an early stage, but all these treatments have various adverse effects on human health. Cancer cells proliferate more rapidly than most normal cells, so chemotherapy is the most suitable treatment. Certain medications can cease dividing cells by destroying the cell's control center region. Other drugs can inhibit the chemical processes essential for cell division. On the contrary, because cancer is frequently identified at a late phase, treating the disease is extraordinarily challenging. Therefore, it is advisable to avoid this fatal condition from occurring. Multiple studies have revealed a continuous inverse connection between cancer and natural materials, such as plant extracts, their fractions, and active principles. These bioactive phytochemicals' have synergistic or cumulative effects in the treatment of cancer disease. This review article examined the effect of various extracts/fractions/active principles obtained from diverse plant origins against breast cancer disease. Information regarding the most commonly used plants, including Alpina galaga, Urtica dioica, Annona muricata, Rosmarinus officinalis, Ficus carica, Nigella sativa, Murraya koenigii, and Urtica dioica have been presented in this study. Owing to the information in this study, these plants exhibited anticancer activities in preclinical MCF-7 carcinoma models by decreasing cell proliferation, inducing programmed cell death, and triggering cell-cycle arrest. The information generated from this review will significantly contribute to developing knowledge of the scientific and medical communities in developing innovative breast cancer treatments.

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“…24,25,28,34,36,50−52 Multiple types of dopants, e.g., cobalt, nickel, copper, zinc, and rare-earth elements are broadly applied for doping purposes. 23,24,26,28,29 At present, doped-IONPs have found widespread applications in drug delivery, antimicrobial and anticancer activities, MRI imaging agent. 53−56 Moreover, when doped-IONPs are employed as antimicrobial agents, transition metals are mainly utilized due to their antimicrobial characteristics in their bulk form.…”

Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 99%

“…28,29,52 While doped-IONPs larger than 200 nm demonstrated comparatively poor antimicrobial activity. [24][25][26]29,30,36 Additionally, IONPs doped with transition metals shown significant antimicrobial activity based on the synthesis process, size, concentrations, and application. 25,30,50 Doped-IONPs were synthesized by using CP, CPA, MAP, GC, SGP, HDA, and solvothermal approach.…”

Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 99%

The Promise of Metal-Doped Iron Oxide Nanoparticles as Antimicrobial Agent

Tasnim,

Ferdous,

Rumon

et al. 2023

ACS Omega

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Antibiotic resistance (AMR) is one of the pressing global public health concerns and projections indicate a potential 10 million fatalities by the year 2050. The decreasing effectiveness of commercially available antibiotics due to the drug resistance phenomenon has spurred research efforts to develop potent and safe antimicrobial agents. Iron oxide nanoparticles (IONPs), especially when doped with metals, have emerged as a promising avenue for combating microbial infections. Like IONPs, the antimicrobial activities of doped-IONPs are also linked to their surface charge, size, and shape. Doping metals on nanoparticles can alter the size and magnetic properties by reducing the energy band gap and combining electronic charges with spins. Furthermore, smaller metal-doped nanoparticles tend to exhibit enhanced antimicrobial activity due to their higher surface-to-volume ratio, facilitating greater interaction with bacterial cells. Moreover, metal doping can also lead to increased charge density in magnetic nanoparticles and thereby elevate reactive oxygen species (ROS) generation. These ROS play a vital role to disrupt bacterial cell membrane, proteins, or nucleic acids. In this review, we compared the antimicrobial activities of different doped-IONPs, elucidated their mechanism(s), and put forth opinions for improved biocompatibility.

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Antibacterial and antiproliferation activity of green synthesized nanoparticles from rhizome extract of Alpinia galangal (L.) Wild

Cited by 8 publications

References 26 publications

Current Trends and Prospects for Application of Green Synthesized Metal Nanoparticles in Cancer and COVID-19 Therapies

Current Trends and Prospects for Application of Green Synthesized Metal Nanoparticles in Cancer and COVID-19 Therapies

The use of medicinal plants for combating breast cancer: A comprehensive review

The Promise of Metal-Doped Iron Oxide Nanoparticles as Antimicrobial Agent

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