Antibacterial and antioxidant chitosan nanoparticles improve the preservation effect for donor kidneys in vitro

Zhang, Qiuyan; Tong, Jun; Zhou, Wei; Zhong, Zibiao; Hu, Qianchao; Ma, Qiang; Long, Haitao; Wu, Shyi-Kuen; Shi, Xiaowen; Ye, Qifa

doi:10.1016/j.carbpol.2022.119326

Cited by 11 publications

(3 citation statements)

References 50 publications

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“…Additionally, we modified chitosan via quaternization. The quaternary ammonium salt group is a hydrophilic group with a positive charge, and quaternization-modified chitosan not only improves water solubility but also increases electropositivity, which facilitates the assembly of NPs and adsorption of antigenic proteins. , The ionic gel method was adopted to prepare the NPs to avoid damaging the antigenic proteins via the use of organic reagents and vigorous reactions. Furthermore, SEPS was selected as a cross-linking agent to assemble NPs more tightly, which is beneficial in reducing the particle size of NPs and enhancing recognition of antigens by immune cells .…”

Section: Discussionmentioning

confidence: 99%

Self-Assembling Sulfated Lactobacillus Exopolysaccharide Nanoparticles as Adjuvants for SARS-CoV-2 Subunit Vaccine Elicit Potent Humoral and Cellular Immune Responses

Zhang,

Fan,

Ding

et al. 2024

ACS Appl. Mater. Interfaces

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Coronavirus disease 2019 (COVID-19) has caused a global pandemic since its onset in 2019, and the development of effective vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to induce potent and long-lasting immunity remains a priority. Herein, we prepared two Lactobacillus exopolysaccharide (EPS) nanoparticle adjuvants (NPs 7-4 and NPs 8-2) that were constructed by using sulfation-modified EPS and quaternization-modified chitosan. These two NPs displayed a spherical morphology with sizes of 39 and 47 nm. Furthermore, the zeta potentials of NPs 7-4 and NPs 8-2 were 50.40 and 44.40 mV, respectively. In vitro assays demonstrated that NPs could effectively adsorb antigenic proteins and exhibited a sustained release effect. Mouse immunization tests showed that the NPs induced the expression of cytokines and chemokines at the injection site and promoted the uptake of antigenic proteins by macrophages. Mechanically, the NPs upregulated the expression of pattern recognition receptors (toll-like receptors and nod-like receptors) and activated the immune response of T cells and the production of neutralizing antibodies. In addition, the NP adjuvants had favorable immune-enhancing effects in cats, which are of great significance for controlling the trans-host transmission and reendemicity of SARS-CoV-2. Overall, we demonstrated that NP-adjuvanted SARS-CoV-2 receptor binding domain proteins could induce robust specific humoral and cellular immunity.

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Section: Discussionmentioning

confidence: 99%

Self-Assembling Sulfated Lactobacillus Exopolysaccharide Nanoparticles as Adjuvants for SARS-CoV-2 Subunit Vaccine Elicit Potent Humoral and Cellular Immune Responses

Zhang,

Fan,

Ding

et al. 2024

ACS Appl. Mater. Interfaces

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“…Alda-1 loaded N-alkyl-O-HTCC micelles [ 301] Positive charge -221 ± 3.70 45.6 ± 0.64 Alda-1; Chitosan Renal fibrosis CeNP-PEG [302] --12.73 ± 1.32 -9.00 ± 0.66 Ceria NPs Acute liver injury SIL/BSA NPs [ 316] --9 0 ± 29 -Silibinin APAP-induced liver injury TSCs [57] -Tannic acid ≈50 −11.28 SOD; CAT Drug-induced hepatitis cPBA-BE [208] TBI H 2 O 2 and pH response ≈100 -Baicalein…”

Section: Kidney Donationmentioning

confidence: 99%

Revitalizing Ancient Mitochondria with Nano‐Strategies: Mitochondria‐Remedying Nanodrugs Concentrate on Disease Control

Long,

Liu,

Nan

et al. 2024

Advanced Materials

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Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad of vital functions across diverse cellular processes. Dysfunctions within mitochondria serve as catalysts for various diseases, prompting widespread cellular demise. Mounting research on remedying damaged mitochondria indicates that mitochondria constitute a valuable target for therapeutic intervention against diseases. But the less clinical practice and lower recovery rate imply the limitation of traditional drugs, which need a further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution and high efficacy by capitalizing on excellent nanomaterials and targeting drug delivery. Mitochondria‐remedying nanodrugs have achieved ideal therapeutic effects. In this review, we have elucidated the significance of mitochondria in various cells and organs, while also compiling mortality data for related diseases. Correspondingly, nanodrug‐mediate therapeutic strategies and applicable mitochondria‐remedying nanodrugs in disease were detailed, with a full understanding of the roles of mitochondria dysfunction and the advantages of nanodrugs. In addition, the future challenges and directions have been widely discussed. In conclusion, this review provides comprehensive insights into the design and development of mitochondria‐remedying nanodrugs, aiming to help scientists who desire to extend their research fields and engage in this interdisciplinary subject.This article is protected by copyright. All rights reserved

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“…Additionally, PLGA-NPs conjugated with antibodies targeting the intercellular adhesion molecule 1 have been used to reduce graft immunogenicity 68 , and similar approaches could be used to target MHC-II molecules on allograft ECs. The delivery during hypothermic machine perfusion of NPs micelles containing an activator of mitochondrial acetaldehyde dehydrogenase 2, a key enzyme involved in protection against tissue injuries of various origin, ischemia included, reduced the ischemic damage and improved the function of high-risk, controlled, DCD kidneys donation 69 . Oxidative stress plays a key role in IRI, and antioxidant treatments include increasing endogenous antioxidants, supplementation of exogenous antioxidants, and strategies to reducing oxidative stress.…”

Section: Nanotechnologymentioning

confidence: 99%

Organ Therapeutics During Ex-Situ Dynamic Preservation. A Look Into the Future

Martins

Turco

Gilbo

2022

EJT

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Antibacterial and antioxidant chitosan nanoparticles improve the preservation effect for donor kidneys in vitro

Cited by 11 publications

References 50 publications

Self-Assembling Sulfated Lactobacillus Exopolysaccharide Nanoparticles as Adjuvants for SARS-CoV-2 Subunit Vaccine Elicit Potent Humoral and Cellular Immune Responses

Self-Assembling Sulfated Lactobacillus Exopolysaccharide Nanoparticles as Adjuvants for SARS-CoV-2 Subunit Vaccine Elicit Potent Humoral and Cellular Immune Responses

Revitalizing Ancient Mitochondria with Nano‐Strategies: Mitochondria‐Remedying Nanodrugs Concentrate on Disease Control

Organ Therapeutics During Ex-Situ Dynamic Preservation. A Look Into the Future

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