Antibacterial and Antioxidant Activity of Extracts from Rose Fruits (Rosa rugosa)

Cendrowski, Andrzej; Kraśniewska, Karolina; Przybył, Jarosław L.; Zielińska, Agnieszka; Kalisz, Stanisław

doi:10.3390/molecules25061365

Cited by 42 publications

(39 citation statements)

References 40 publications

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“…It has also been cultivated in North America and Europe as an introduced ornamental plant. The fruits of R. rugosa possess antioxidant activity and antibacterial activity due to their high contents of phenolic and flavonoid compounds and ascorbic acid 1 , 2 . It is able to control soil erosion and is planted along highways in Germany and Denmark 3 .…”

Section: Introductionsmentioning

confidence: 99%

A chromosome-level genome assembly of rugged rose (Rosa rugosa) provides insights into its evolution, ecology, and floral characteristics

Chen

et al. 2021

Hortic Res

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Rosa rugosa, commonly known as rugged rose, is a perennial ornamental shrub. It produces beautiful flowers with a mild fragrance and colorful seed pods. Unlike many other cultivated roses, R. rugosa adapts to a wide range of habitat types and harsh environmental conditions such as salinity, alkaline, shade, drought, high humidity, and frigid temperatures. Here, we produced and analyzed a high-quality genome sequence for R. rugosa to understand its ecology, floral characteristics and evolution. PacBio HiFi reads were initially used to construct the draft genome of R. rugosa, and then Hi-C sequencing was applied to assemble the contigs into 7 chromosomes. We obtained a 382.6 Mb genome encoding 39,704 protein-coding genes. The genome of R. rugosa appears to be conserved with no additional whole-genome duplication after the gamma whole-genome triplication (WGT), which occurred ~100 million years ago in the ancestor of core eudicots. Based on a comparative analysis of the high-quality genome assembly of R. rugosa and other high-quality Rosaceae genomes, we found a unique large inverted segment in the Chinese rose R. chinensis and a retroposition in strawberry caused by post-WGT events. We also found that floral development- and stress response signaling-related gene modules were retained after the WGT. Two MADS-box genes involved in floral development and the stress-related transcription factors DREB2A-INTERACTING PROTEIN 2 (DRIP2) and PEPTIDE TRANSPORTER 3 (PTR3) were found to be positively selected in evolution, which may have contributed to the unique ability of this plant to adapt to harsh environments. In summary, the high-quality genome sequence of R. rugosa provides a map for genetic studies and molecular breeding of this plant and enables comparative genomic studies of Rosa in the near future.

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Section: Introductionsmentioning

confidence: 99%

A chromosome-level genome assembly of rugged rose (Rosa rugosa) provides insights into its evolution, ecology, and floral characteristics

Chen

et al. 2021

Hortic Res

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“…Prospecting for plants that are rich in phenolic compounds is supported by studies highlighting the strong correlation between phenolic content and antioxidant capacity [ 64 ]. Furthermore, compounds exhibiting an antioxidant capacity tend to present other activities, such as anti-diabetic [ 65 ], anti-inflammatory [ 66 ], antibacterial [ 67 , 68 , 69 ] and antiproliferative activities [ 70 ]. Determining the antioxidant capacity by means of the ORAC assay is one of the best methods currently used [ 71 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

Constituents of Chamaecrista diphylla (L.) Greene Leaves with Potent Antioxidant Capacity: A Feature-Based Molecular Network Dereplication Approach

et al. 2021

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Chamaecrista diphylla (L.) Greene (Fabaceae/Caesalpiniaceae) is a herbaceous plant that is widely distributed throughout the Americas. Plants from this genus have been used in traditional medicine as a laxative, to heal wounds, and to treat ulcers, snake and scorpion bites. In the present study, we investigated the chemical composition of Chamaecrista diphylla leaves through a mass spectrometry molecular network approach. The oxygen radical absorbance capacity (ORAC) for the ethanolic extract, enriched fractions and isolated compounds was assessed. Overall, thirty-five compounds were annotated for the first time in C. diphylla. Thirty-two of them were reported for the first time in the genus. The isolated compounds 9, 12, 24 and 33 showed an excellent antioxidant capacity, superior to the extract and enriched fractions. Bond dissociation energy calculations were performed to explain and sustain the antioxidant capacity found. According to our results, the leaves of C. diphylla represent a promising source of potent antioxidant compounds.

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“…In recent years, many researchers had reported the pharmacological and chemical properties of genus "Rosa". For instance, [31,32] discussed the antioxidant and antibacterial potential of Rosa canina and Rosa rugosa, respectively. The fruit extract of R. brunonii reveals the presence of strong antioxidant phytochemical constituents, antioxidant stress and protective potential against Rif/ INH-induced hepatic and renal damage [33].…”

Section: Discussionmentioning

confidence: 99%

Fruits of Rosa brunonii Lindle: An Ethnomedicinal Plant from Foothills of Himalaya with Antibacterial, Antitumor and Cytotoxic Properties

2021

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Traditional uses of plants are one of the important starting points in search of newer and more effective bioactive drug. Rosa brunonii (plant's family; Rosaceae) is an ethnomedicinal shrub found in lesser Himalaya region. In traditional medicines, it is used as "blood purifier, to stimulate wound healing, to treat infectious diseases". So, by considering the medicinal potential of Rosa brunonii, the methanolic fruit's extract was tested against two gram positive and three gram negative bacteria by agar well diffusion method. The maximum antibacterial potential was noticed against Klebsiella pneumoniae (94 ± 0.3 mm inhibition zone, MIC = 62.5 ± 1.1 µg/mL), while minimum antibacterial activity was shown by the plant extract against Bacillus subtilis (MIC = 250 ± 7.2 µg/mL). The cytotoxic properties of crude methanolic extract were determined by brine shrimp lethality test. A dose-dependent cytotoxic effect was observed for the plant extract at p < 0.05, F (3,8) = 1.58 with LD 50 220.95 ± 1.03 µg/mL. Antitumor potential was evaluated by potato disk antitumor bioassay. Fruit's extract of R. brunonii showed maximum tumor inhibition at 1000 µg/mL by 72.73% with IC 50 = 655.65 ± 0.03 µg/mL. Preliminary phytochemical analysis revealed that extract is devoid of alkaloid but rich in phenolics. Total phenolic and flavonoid contents were determined as 66.73 ± 3.89 µg/mg GAE and 46.51 ± 0.96 µg/mg QE, respectively, in R. brunonii. The present study underlined the ethnomedicinal importance of R. brunonii and promised useful candidate for the search of newer and effective bioactive constituents. Keywords Rosa brunonii • Ethnomedicinal potential • Antibacterial and cytotoxic properties • Antitumor potential • Total phenolics • Total flavonoids contents Abbreviations BSLT Brine shrimp lethality test CFU Colony forming units CME Crude methanolic extract GAE Gallic acid equivalent IC Inhibition concentration LD Lethal dose MIC Minimum inhibitory concentration QE Quercetin equivalent

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Antibacterial and Antioxidant Activity of Extracts from Rose Fruits (Rosa rugosa)

Cited by 42 publications

References 40 publications

A chromosome-level genome assembly of rugged rose (Rosa rugosa) provides insights into its evolution, ecology, and floral characteristics

A chromosome-level genome assembly of rugged rose (Rosa rugosa) provides insights into its evolution, ecology, and floral characteristics

Constituents of Chamaecrista diphylla (L.) Greene Leaves with Potent Antioxidant Capacity: A Feature-Based Molecular Network Dereplication Approach

Fruits of Rosa brunonii Lindle: An Ethnomedicinal Plant from Foothills of Himalaya with Antibacterial, Antitumor and Cytotoxic Properties

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