ANTIBACTERIAL AND ANTIFUNGAL TERPENES FROM Pilgerodendron uviferum (D. DON) FLORIN

Solis, Chacón; Becerra, José; Fuentes, César M.; Robledo, J.; Silva, M.

doi:10.4067/s0717-97072004000200010

Cited by 57 publications

(41 citation statements)

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“…10 This study also identified a number of other minor terpenoidcomponents such as α-cubebene, α-copaene, α-humulene, germacrene-D, γ-cadinene and δ-cadinene, which were present in lower levels. Many of these terpenoidshave potent broad spectrum antibacterial activity [35][36] and therefore may contribute to the bacterial growth inhibitory activity in our study. Interestingly, several of these monoterpenoids including limonene [37][38] and α-pinene 39 have also been reported to suppress NF-κB signaling (the major regulator of inflammatory diseases).α-Pinene affects inflammation by inhibiting p65 translocation into the nucleus in LPS-induced NF-κB signalling.…”

Section: Discussionmentioning

confidence: 99%

The Therapeutic Properties of Juniperus Communis L.: Antioxidant Capacity, Bacterial growth Inhibition, Anticancer Activity and Toxicity

Fernández¹,

Cock²

2016

Phcogj

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Introduction: J. communis berry is a high antioxidant fruit which is used in several traditional medicinal systems to treat a variety of diseases including rheumatism, arthritis and gout.This study was undertaken to examine the inhibitory activity of J. communis berry extracts on the growth of several bacteria associated with autoimmune inflammatory disease, and to test their ability to block CaCo 2 and HeLa cancer cell proliferation. Methods: J. Communis solvent extracts were prepared using solvents of varying polarity. The extracts were investigated by disc diffusion assay for the ability to inhibit the growth of a panel of pathogenic bacteria associated with autoimmune inflammatory diseases. Their MIC values were determined to quantify and compare their efficacies. Inhibitory activity against CaCo 2 and HeLa human carcinoma cell lines was evaluated using an MTS colorimetric cell proliferation assay. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: The methanol, water and ethyl acetate J. communis berry extracts displayed moderate to potent growth inhibitory activity against bacterial triggers of rheumatoid arthritis, ankylosing spondylitis and multiple sclerosis. The methanol and water extracts displayed the broadest specificity, inhibiting the growth of all bacteria tested. The ethyl acetate extract also displayed antibacterial activity, inhibiting the growth of 9 of the 13 bacterial strains (69%). The ethyl acetate extract displayed the greatest potency, with MIC values substantially below 2000 µg/mL for all bacteria which it inhibited. It was most effective at inhibiting the growth of P. mirabilis, P. vulgaris and S. aureus, each with MIC's ≤ 500 µg/mL. The

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Section: Discussionmentioning

confidence: 99%

The Therapeutic Properties of Juniperus Communis L.: Antioxidant Capacity, Bacterial growth Inhibition, Anticancer Activity and Toxicity

Fernández¹,

Cock²

2016

Phcogj

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“…It shows broad antimicrobial activity against bacterial pathogens by inducing membrane disruption followed by the efflux of bacterial cytosolic contents [37]. Antibacterial and antifungal terpenes have been isolated from Pilgerodendron uviferum (D. Don) Florin [38]. A sterol, 7-aminocholesterol displayed antibiotic activity against Saccharomyces cerevisiae, S. aureus, Enterococcus hirae and Bacillus cereus [39].…”

Section: Discussionmentioning

confidence: 99%

Activity of solvent extracts of Prosopis spicigera, Zingiber officinale and Trachyspermum ammi against multidrug resistant bacterial and fungal strains

Khan

Zakir

Afaq

et al. 2010

J Infect Dev Ctries

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Background: The emerging trends of multidrug resistance among several groups of microorganisms against different classes of antibiotics led different researchers to develop efficient drugs from plant sources to counter multidrug resistant strains. This study investigated different solvent extracts of Prosopis spicigera (P. Spicigera), Zingiber officinale, and Trachyspermum ammi (T. ammi) to determine their efficacy against multidrug resistant microbes. Methodology: Successive extractions of these plants were performed using a Soxhlet apparatus, using solvents with increasing polarities. Preliminary phytochemical analysis was also performed .Minimum inhibitory concentration was determined by a two-fold serial dilution method followed by determination of minimum bactericidal/fungicidal concentration. Multidrug resistant (MDR) strains of Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata, Escherichia coli and reference strains of Streptococcus mutans and Streptococcus bovis were used in the study. Results: The ethanolic fraction of P. spicigera (least minimum inhibitory concentration [MIC] -4.88 µg/ml) demonstrated a remarkable inhibition of the microorganisms while fractions obtained from those of Zingiber officinale (least MIC-78.125 µg/ml) exhibited little activity. The petroleum ether fraction of T. ammi (least MIC-625 µg/ml) showed best activity when compared to its other fractions. Qualitative analysis of the phytoconstituents was also performed. Conclusions: The potency shown by these extracts recommends their use against multidrug resistant microorganisms. This study also showed that P. spicigera could be a potential source of new antimicrobial agents.

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“…In addition, sesquiterpene hydrocarbons such as humulene, germacrene-D, dcadinene, α-cubebene, α-copaene, γ-cadinene, and β-elemene have shown antimicrobial activity (Haznedaroglu et al, 2001;Rahman et al, 2008;Solis et al, 2004). This indicates that antimicrobial activity of essential oil extracted from Siberian ginseng fruit might be due to the presence of sesquiterpene hydrocarbons as main constituents.…”

Section: Chemical Composition Of the Essential Oilmentioning

confidence: 99%

Composition, antioxidant and antimicrobial activities of Eleutherococcus senticosus fruit extracts

Jang¹,

Lee²,

Eom³

et al. 2016

J App Pharm Sci

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This study was designed to examine the in vitro antioxidant and antimicrobial activities of essential oil and crude methanolic (MeOH) extract of Eleutherococcus senticosus (common name, Siberian ginseng) fruit and its partitioned fractions, including hexane, ethyl acetate (EtOAc), n-butanol (BuOH) and aqueous. 1,1-dephenyl-2-picryl-hydrazyl free radical scavenging and reducing power assay suggest that antioxidant activity of EtOAc and BuOH fractions is due to the reducing ability of the antioxidant against oxidative effects of reactive oxygen species. In addition, the essential oil of Siberian ginseng fruit showed remarkable antimicrobial activity against Kocuria rhizophila (MIC = 125 µg/ml), Micrococcus luteus (MIC = 500 µg/ml), and Escherichia coli (MIC = 63 µg/ml). The chemical compositions of the essential oil obtained by the simultaneous steam-distillation and extraction method were analyzed using GC-MS; trans-caryophyllene (21.7%), humulene (7.4%), bicyclogermacrene (6.0%), (+) spathulenol (4.5%), germacrene-D (3.2%), tau-muurolol (2.5%) and deltacadinene (2.3%) were found as main constituents. Furthermore, HPLC analysis identified ursolic acid as one of the principal components in Siberian ginseng fruit extract. Although this study has been carried out by in vitro assay, these results suggest that Siberian ginseng fruit may be a good candidate as a source of antioxidant and antimicrobial ingredients.

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ANTIBACTERIAL AND ANTIFUNGAL TERPENES FROM Pilgerodendron uviferum (D. DON) FLORIN

Cited by 57 publications

References 0 publications

The Therapeutic Properties of Juniperus Communis L.: Antioxidant Capacity, Bacterial growth Inhibition, Anticancer Activity and Toxicity

The Therapeutic Properties of Juniperus Communis L.: Antioxidant Capacity, Bacterial growth Inhibition, Anticancer Activity and Toxicity

Activity of solvent extracts of Prosopis spicigera, Zingiber officinale and Trachyspermum ammi against multidrug resistant bacterial and fungal strains

Composition, antioxidant and antimicrobial activities of Eleutherococcus senticosus fruit extracts

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