Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of Anvillea garcinii

Abstract

Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide (1), and germacrane, 9β-hydroxyparthenolide-9-O-β-D-glucopyranoside (2), classes have been isolated from the leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3–9). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of 1–9 were screened against seven different pathogenic microbes, and compounds 1–3 showed a potent antifungal activity.

Glycosylated Phenols and an Unprecedented Diacid from the Saudi Plant Cissus rotundifolia

“…In the context of our ongoing research project aimed at the phytochemical and biological characterization of medicinal plants of the Arabian Peninsula, , we have undertaken a bioassay-guided investigation of the extracts obtained from leaves of a Saudi sample of C. rotundifolia with the aim of finding compounds active in the promotion of glucose uptake in hepatic cells. Chemical analysis of the bioactive fractions afforded the new sucrose diester cissuxinoside ( 1 ), the new C 12 diacid glucoside cissoic acid ( 2 ), three glycosylflavones ( 3 – 5 ), one of which was chemically characterized for the first time, and two coumaric acid derivatives, including 1- O -(4-coumaroyl)-β- d -glucopyranose ( 7 ), responsible for the activity of the extract.…”

“…In the context of our ongoing research project aimed at the phytochemical and biological characterization of medicinal plants of the Arabian Peninsula, 9,10 coumaroyl)-β-D-glucopyranose (7), responsible for the activity of the extract.…”

Antibacterial and Antifungal Sesquiterpenoids: Chemistry, Resource, and Activity

“…4 α ,9 α ,10 α -Trihydroxyguaia-11(13)en-12,6 α -olide ( 31 , Figure 4 ) was collected from the leaves of the Saudi medicinal plant Anvillea garcinii . Compound 31 had antibacterial activity against C. albicans , C. parapsilosis, S. aureus, B. licheniformis, and E. fergusonii , with MIC values of 0.21 , 0.25 , 2.3, 2.3, and 5.7 µg/mL, respectively [ 24 ]. 8- O -[3’-Hydroxy-2’-methylpropionate] ( 32 , Figure 4 ), extracted from the aerial parts of Centaurea rhizantha , had moderate antibacterial activity against S. aureus , and the MIC/MBC value was 500 µg/mL.…”

Phagocytosis, Degranulation and Extracellular Traps Release by Neutrophils—The Current Knowledge, Pharmacological Modulation and Future Prospects

“…radiate ( Boukemara et al, 2016 ). This plant was used for symptomatic treatment of cold ( Perveen et al, 2020 ), but the successful treatment was related to the presence of flavonoids and sesquiterpene lactones, which show significant antibacterial and antifungal properties ( Perveen et al, 2020 ). Thus, based on traditional use of A. garcinii , further evaluation of phagocytosis seems to be worth exploring.…”