Antibacterial and antifungal screening of newly synthesized benzimidazole-clubbed chalcone derivatives

Parikh, Kalpesh; Joshi, Durga Datt

doi:10.1007/s00044-012-0369-3

Cited by 38 publications

(22 citation statements)

References 25 publications

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“…There has been an increased interest in the investigation of antimicrobial activities of 2‐substituted benzofuran derivatives . Also, benzimidazole derivatives show antiparasitic, antibacterial, anthelmintic, analgesic, anti‐inflammatory, anticancer and antitubercular activities. The structural diversity of the moieties as well as their biological and pharmaceutical importance have motivated research to develop new classes of benzofuran‐substituted benzimidazoles.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and spectroscopic characterization of transition metal complexes derived from novel benzofuran hydrazone chelating ligand: DNA cleavage studies and antimicrobial activity with special emphasis on antituberculosis

Kokare

Naik

Nevrekar

et al. 2016

Applied Organom Chemis

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Mononuclear divalent complexes of Co, Ni, Cu and Zn derived from a benzofuran‐based novel hydrazone tridentate ligand were synthesized and characterized using various spectroscopic methods. Elemental analysis reveals that the metal‐to‐ligand ratio is 1:2 which is supported by mass spectrometry results. Conductivity measurements suggest that all the complexes are non‐electrolytic in nature. The ligand and complexes were evaluated for their antimicrobial potency. Bioassay of all hydrazone chelates shows enhanced activity as compared to that of the ligand. The complex with cobalt ion as the metal centre shows better activity against fungi than the standard. Also, ligand and complexes were screened for antituberculosis activity; some analogues (Ni, Cu, Zn) are eight times more active than the standard. Both ligand and complexes show moderate ability to cleave calf thymus DNA. Copyright © 2015 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Synthesis and spectroscopic characterization of transition metal complexes derived from novel benzofuran hydrazone chelating ligand: DNA cleavage studies and antimicrobial activity with special emphasis on antituberculosis

Kokare

Naik

Nevrekar

et al. 2016

Applied Organom Chemis

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“…This action could be attributed to some specific interactions with bacterial targeting pathways, which induce a decrease in bacterial growth without bacterial lysis. Indeed, several studies showed numerous targeting pathways such as a disruption of potassium transport, protein coagulation and quorum sensing inhibition [29][30][31][32][33][34] . These results would be partially in accordance with the results of the Agar-well diffusion method in which the Compound 4b presented the largest inhibition halo than other molecules including the molecule 3b.…”

Section: Determination Of the Minimum Inhibitory Concentration (Mic) mentioning

confidence: 99%

Novel 2-mercaptobenzimidazole derivatives: synthesis and evaluation of its antibacterial and antioxidant activities

Ouasif

Bouyahya

Zniber³

et al. 2017

Mediterr.J.Chem.,

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In the present study, a series of novel 2-mercapto-benzimidazolium were synthesized from 2-mercapto-benzimidazole with hydrocarbon chains. All compounds obtained are reported for the first time, and the structures of these compounds were confirmed by means of 1H-NMR, 13C-NMR and mass spectrometry. The newly synthesized compounds were subjected to in vitro biological evaluation. The antibacterial activity was evaluated will diffusion assay and density optic method. The antioxidant activity was carried out using DPPH free radical scavenging assay. The result indicated that some compounds show convincing antibacterial activities against two microorganisms: Escherichia coli and Staphylococcus aureus. While, these molecules have not shown interesting antioxidant effects.

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“…Arbutin is also found in bearberry, strawberry, wheat, and in trace amounts in tea, coffee, red wine, and broccoli. Although the studies on bioavailability of chalcones from food sources are limited, synthetic chalcones are reported to have important and diverse pharmacological applications [26][27][28][29][30][31][32][33][34][35][36][37]. In an effort to search for novel antiglycating agents, and as a continuation of our ongoing project on the synthesis, spectral characterization, and applications of chalcone intermediates and various heterocycles [38][39][40][41][42][43], we thought it worthwhile to evaluate B-ring 4-alkoxychalcones (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of 4-alkoxychalcones as a new class of antiglycating agents: a combined experimental and docking study

Abbas

Kalsoom

Hadda³

et al. 2014

Res Chem Intermed

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A series of 4-alkoxychalcones (1-12) has been evaluated for their in vitro antiglycation activity. Compound 2 (IC 50 = 89.07 ± 1.3 lM), compound 3 (IC 50 = 266.82 ± 4.6 lM), and compound 5 (IC 50 = 285.79 ± 1.9 lM) showed an excellent antiglycation potential better than the standard (rutin, IC 50 = 294.50 ± 1.5 lM). Additionally, all the compounds of this series were evaluated for their cytotoxicity against Artemia salina (brine shrimp) and one tumor cell line, namely human Prostate Cancer cell line (PC-3). All the compounds showed low toxicity against brine shrimp with LD 50 values much lower than the standard etoposide. Similarly, a much lower toxicity was observed for all the compounds against PC-3 cell line compared to doxorubicin, a standard reference drug used for this study. The molecular docking studies were also carried out to support the experimental results. A good correlation was found between experimental and theoretical results. The compounds of this series are therefore excellent antiglycating agents with no or very little cytotoxicity and represent a new class of antiglycating agents that deserve to be focused on for further research and in vivo studies in the future.

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Antibacterial and antifungal screening of newly synthesized benzimidazole-clubbed chalcone derivatives

Cited by 38 publications

References 25 publications

Synthesis and spectroscopic characterization of transition metal complexes derived from novel benzofuran hydrazone chelating ligand: DNA cleavage studies and antimicrobial activity with special emphasis on antituberculosis

Synthesis and spectroscopic characterization of transition metal complexes derived from novel benzofuran hydrazone chelating ligand: DNA cleavage studies and antimicrobial activity with special emphasis on antituberculosis

Novel 2-mercaptobenzimidazole derivatives: synthesis and evaluation of its antibacterial and antioxidant activities

Evaluation of 4-alkoxychalcones as a new class of antiglycating agents: a combined experimental and docking study

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