Antibacterial and antifungal activity of phytosterols and methyl dehydroabietate of Norway spruce bark extracts

Burčová, Zuzana; Kreps, František; Greifová, Mária; Jablonský, Michal; Ház, Aleš; Schmidt, Štefan; Šurina, Igor

doi:10.1016/j.jbiotec.2018.06.340

Cited by 68 publications

(48 citation statements)

References 25 publications

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“…Within the large family of terpenoids, diterpenoid acids (called resin acids) constitute the largest part of the oleoresin (Higuchi, 1997), and they have been repeatedly shown to have fungicidal properties (Keeling and Bohlmann, 2006), which is also the case for triterpenes, known as sterols (Burčová et al, 2018). Triglycerides and fatty acids may have a role in moisture regulation (Tomppo et al, 2011), which is important in the context of degradation by microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Understanding the Formation of Heartwood in Larch Using Synchrotron Infrared Imaging Combined With Multivariate Analysis and Atomic Force Microscope Infrared Spectroscopy

et al. 2020

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Formation of extractive-rich heartwood is a process in live trees that make them and the wood obtained from them more resistant to fungal degradation. Despite the importance of this natural mechanism, little is known about the deposition pathways and cellular level distribution of extractives. Here we follow heartwood formation in Larix gmelinii var. Japonica by use of synchrotron infrared images analyzed by the unmixing method Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS). A subset of the specimens was also analyzed using atomic force microscopy infrared spectroscopy. The main spectral changes observed in the transition zone when going from sapwood to heartwood was a decrease in the intensity of a peak at approximately 1660 cm-1 and an increase in a peak at approximately 1640 cm-1. There are several possible interpretations of this observation. One possibility that is supported by the MCR-ALS unmixing is that heartwood formation in larch is a type II or Juglans-type of heartwood formation, where phenolic precursors to extractives accumulate in the sapwood rays. They are then oxidized and/or condensed in the transition zone and spread to the neighboring cells in the heartwood.

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Section: Introductionmentioning

confidence: 99%

Understanding the Formation of Heartwood in Larch Using Synchrotron Infrared Imaging Combined With Multivariate Analysis and Atomic Force Microscope Infrared Spectroscopy

et al. 2020

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“…Apart from a role in moisture regulation, the potential of RAs as biocides against multiple insects and micro-organisms was shown in numerous in vivo and in vitro assays (Micales et al, 1994 ; Nerg et al, 2004 ; Keeling and Bohlmann, 2006 ; Mason et al, 2015 ), including white rot fungi (Eberhardt et al, 1994 ), and brown rot fungi (Micales et al, 1994 ; Nerg et al, 2004 ). Sterols (STs), which are triterpenoids, have potential as growth retardants in bacteria, and a synergistic role with RAs has been proposed (Burčová et al, 2018 ). Representative chemical structures of compounds, belonging to these families and relevant for this study, can be viewed in Figure S1.1–7 .…”

Section: Introductionmentioning

confidence: 99%

Hydrophobic and Hydrophilic Extractives in Norway Spruce and Kurile Larch and Their Role in Brown-Rot Degradation

et al. 2020

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Extractives found in the heartwood of a moderately durable conifer (Larix gmelinii var. japonica) were compared with those found in a non-durable one (Picea abies). We identified and quantified heartwood extractives by extraction with solvents of different polarities and gas chromatography with mass spectral detection (GC-MS). Among the extracted compounds, there was a much higher amount of hydrophilic phenolics in larch (flavonoids) than in spruce (lignans). Both species had similar resin acid and fatty acid contents. The hydrophobic resin components are considered fungitoxic and the more hydrophilic components are known for their antioxidant activity. To ascertain the importance of the different classes of extractives, samples were partially extracted prior to subjection to the brown-rot fungus Rhodonia placenta for 2-8 weeks. Results indicated that the most important (but rather inefficient) defense in spruce came from the fungitoxic resin, while large amounts of flavonoids played a key role in larch defense. Possible moisture exclusion effects of larch extractives were quantified via the equilibrium moisture content of partially extracted samples, but were found to be too small to play any significant role in the defense against incipient brow-rot attack.

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“…AA and DHA extracted from food packaging paper in high concentrations can promote a tumor formation [9]. Despite their obvious toxicity on the human body, some RAs can find potential applications in drug development, since they have anti-atherosclerotic [40], anti-inflammatory [24], antidiabetic [41,42], antitumor [43], osteoprotective [44], cytotoxic [45], antimicrobial [12], and anti-biofilm [46] actions.…”

Section: Distribution and Toxicity Of Rasmentioning

confidence: 99%

“…Employing enzymatic activities of microorganisms allows treating these pollutants in one technological stage without the need to use expensive chemicals and under eco-friendly reaction conditions. Despite the obvious toxic effects on living organisms, RAs can be used as parent compounds to derive novel, pharmaceutically significant substances with a broad bioactivity spectrum [12,13].…”

Section: Introductionmentioning

confidence: 99%

Microbial Conversion of Toxic Resin Acids

et al. 2019

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Organic wood extractives—resin acids—significantly contribute to an increase in the toxicity level of pulp and paper industry effluents. Entering open ecosystems, resin acids accumulate and have toxic effects on living organisms, which can lead to the ecological imbalance. Among the most effective methods applied to neutralize these ecotoxicants is enzymatic detoxification using microorganisms. A fundamental interest in the in-depth study of the oxidation mechanisms of resin acids and the search for their key biodegraders is increasing every year. Compounds from this group receive attention because of the need to develop highly effective procedures of resin acid removal from pulp and paper effluents and also the possibility to obtain their derivatives with pronounced pharmacological effects. Over the past fifteen years, this is the first report analyzing the data on distribution, the impacts on living organisms, and the microbial transformation of resin acids. Using the example of dehydroabietic acid—the dominant compound of resin acids in effluents—the review discusses the features of interactions between microorganisms and this pollutant and also highlights the pathways and main products of resin acid bioconversion.

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Antibacterial and antifungal activity of phytosterols and methyl dehydroabietate of Norway spruce bark extracts

Cited by 68 publications

References 25 publications

Understanding the Formation of Heartwood in Larch Using Synchrotron Infrared Imaging Combined With Multivariate Analysis and Atomic Force Microscope Infrared Spectroscopy

Understanding the Formation of Heartwood in Larch Using Synchrotron Infrared Imaging Combined With Multivariate Analysis and Atomic Force Microscope Infrared Spectroscopy

Hydrophobic and Hydrophilic Extractives in Norway Spruce and Kurile Larch and Their Role in Brown-Rot Degradation

Microbial Conversion of Toxic Resin Acids

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