Antibacterial and antifouling properties of a polyurethane surface modified with perfluoroalkyl and silver nanoparticles

Abstract

Inspired by mussel-adhesion phenomena in nature, a simple, mild surface modification process was elaborated to endow the polyurethane (PU) substrate with antibacterial/antifouling properties. In the present study, polydopamine was coated directly onto polyurethane surfaces. AgNO was then added and absorbed onto the surface by the active catechol and amine groups of the polydopamine coating. Meanwhile, the adsorbed Ag ions were reduced in situ into metallic silver nanoparticles by the "bridge" of the polydopamine coating which yielded a coating with good antimicrobial properties. Finally, 1H, 1H, 2H, 2H-perfluorodecanethiol (CF (CF ) CH CH SH, F-SH) was attached on the PDA coating via the Michael addition reaction. The hydrophobic F-SH layer above the antibacterial layer yielded a surface with excellent antifouling properties. Preliminary antibacterial assays indicate that the coated surfaces show enhanced antibacterial activity against Escherichia coli (Gram-negative bacteria) and Staphylococcus aureus (Gram-positive bacteria). Platelet adhesion was significantly reduced for the F-SH-coated PU film. These results suggest that the modified PU could be used as an antibacterial material for future biomedical applications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 531-538, 2017.

Design and synthesis of antibacterial waterborne fluorinated polyurethane

“…The antifouling layer consisted of F‐SH (1 H , 1 H , 2 H , 2 H ‐perfluorodecanethiol) could remove proteins and the residue from dead bacteria cells. The results show that the F‐SH layer yielded a surface with excellent antifouling properties …”

Antimicrobial strategies for urinary catheters

“…To improve the antimicrobial efficacy, an increasing number of novel silver materials have been developed . Silver nanoparticles (Ag NPs) are one of the most attractive material for catheter coatings [Fig.…”

“…To improve the antimicrobial efficacy, an increasing number of novel silver materials have been developed. [38][39][40][41][42][43][44][45][46][47][48] Silver nanoparticles (Ag NPs) are one of the most attractive SCHEME 2. Mechanisms of bactericidal silver ion.…”

“…The Ag NPs are primarily composed of Ag 0 metal with a particle size of <100 nm and very large surfaceto-volume ratio. The microorganisms inhibition mechanism of Ag NPs is related to (1) the release of antibacterial Ag + ion from particle surface [38][39][40][41][42][43][44][45][46][47][48] ; (2) the incorporation of Ag NPs into the bacterial membrane, leading to structural damages and compromised membrane functions, including increase in permeability, disruption of regulated plasma membrane transport, and eventually, causing cell death. 49,50 In addition, silver can be combined with other active materials, showing improved antimicrobial efficacy, for instance, silver coating releasing hydroxyapatite materials, 53 52 The silver-impregnated catheters will continue to play an important role, owing to its broad-spectrum antimicrobial ability, simple preparation, and less side effects.…”

Synthesis and antifouling activities of fluorinated polyurethanes

“…The adherence of bacteria on surfaces is one of the most significant limitations to the endpoint utility of many devices like biomedical implants . Biomaterial‐associated infections caused by indwelling devices have resulted in much human pain and suffering, presenting a significant economic burden to society .…”