Antibacterial and Antifogging Nanopillar Array Films: Targeted Efficacy against Staphylococcus aureus

Abstract

Staphylococcus aureus (S. aureus) is a common bacterium that can cause a wide range of infections in humans. The growth of these bacteria is inhibited by strategies using antibiotics and/or nanomaterials. However, nanomaterials and antibiotics can cause cytotoxicity and antibiotic resistance. Recent research has focused on achieving mechanical inhibition of bacterial growth through the surface nanostructure. Antibacterial use of nanostructured surfaces does not need antibiotics. Meanwhile, transparent films are necessary in the medical, optical, and automotive industries. In this study, we proposed a flexible, transparent, antibacterial, and antifogging film with a nanostructured surface. The bactericidal and bacteriostatic effects were observed on the arrayed nanopillars according to spacing. For S. aureus, bactericidal effect was observed at a nanopillar spacing of 300 nm, and bacteriostatic effect was observed at 500−1000 nm. Furthermore, the antibacterial rate was improved by 94.9% through MPC polymer coating at the surface. In addition, the MPC coating maintained an antibacterial rate of 86.6 and 64.1% for 7 and 14 days, respectively. The hydrophilic MPC-coated surface has properties of antifogging and transparency for potential usage in optical devices. This study provides insight into the potential of nanostructured surfaces using a dual strategy to prevent bacterial infections.

Bactericidal Performance of Nanostructures Resin Surfaces: Nanopillars versus Nanocones

“…In addition, Table reveals that p300d100h140 exhibits the most significant structural spacing among the three nanopillar surfaces. This sizable structural spacing has been advocated for its advantageous impact on bactericidal efficacy. , However, although the top spacing of the structures of both nanocones is close to the 200 nm structural spacing of p300d100h140, the live cell ratios of p200h200 (17.6%) and p200h300 (37.4) are 4.7 and 9.9 times those of p300d100h140, respectively, as shown in Figure b. These findings diverge from the expected pattern of nanopillar spacing’s influence on bactericidal properties and contradict prior literatures. , …”

Broad-Spectrum Antimicrobial Polymer-Coated Fabrics via Commodity Polystyrene Upcycling

“…While this latest pandemic was caused by a virus, infections by pathogenic bacteria and fungi represent no less of a threat due to the emergence of multidrug resistance (MDR). , This critical threat to human health posed by MDR “superbugs” has been attributed to our overuse and misuse of antibiotics and antifungals in past decades. To overcome this problem, functional materials such as antimicrobial peptides, synthetic cationic polymers, − antimicrobial nanomaterials, composites, − and coatings − have been explored. While effective, antimicrobial peptides tend to be costly and susceptible to enzymatic degradation .…”