Antibacterial and anticancerous drug loading kinetics for (10-x)CuO-xZnO-20CaO-60SiO2-10P2O5 (2 ≤ x ≤ 8) mesoporous bioactive glasses

Garg, Shikha; Thakur, Swati; Gupta, Aayush; Kaur, Gurbinder; Pandey, O.P.

doi:10.1007/s10856-016-5827-x

Cited by 34 publications

(12 citation statements)

References 52 publications

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“…The potential of BGs for the delivery of various therapeutic biomolecules has been widely evaluated due to the possibility of incorporating both hydrophilic and hydrophobic groups into their structures [ 101 ]. In this regard, a broad spectrum of both natural and synthetic substances have been incorporated into BGs, in order to improve their biological activities (e.g., antibacterial effect) and, thereby, obtain an enhanced tissue repair and regeneration [ 102 ]. For example, Domingues et al in a pioneering study, used BGs as a controlled release system for tetracycline hydrochloride and its inclusion complex made of tetracycline and b-cyclodextrin [ 103 ].…”

Section: Grand Challenges For the Future—where Are We Going?mentioning

confidence: 99%

Bioactive Glasses: Where Are We and Where Are We Going?

Baino

Hamzehlou

Kargozar

2018

JFB

370

294

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Bioactive glasses caused a revolution in healthcare and paved the way for modern biomaterial-driven regenerative medicine. The first 45S5 glass composition, invented by Larry Hench fifty years ago, was able to bond to living bone and to stimulate osteogenesis through the release of biologically-active ions. 45S5-based glass products have been successfully implanted in millions of patients worldwide, mainly to repair bone and dental defects and, over the years, many other bioactive glass compositions have been proposed for innovative biomedical applications, such as soft tissue repair and drug delivery. The full potential of bioactive glasses seems still yet to be fulfilled, and many of today’s achievements were unthinkable when research began. As a result, the research involving bioactive glasses is highly stimulating and requires a cross-disciplinary collaboration among glass chemists, bioengineers, and clinicians. The present article provides a picture of the current clinical applications of bioactive glasses, and depicts six relevant challenges deserving to be tackled in the near future. We hope that this work can be useful to both early-stage researchers, who are moving with their first steps in the world of bioactive glasses, and experienced scientists, to stimulate discussion about future research and discover new applications for glass in medicine.

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Section: Grand Challenges For the Future—where Are We Going?mentioning

confidence: 99%

Bioactive Glasses: Where Are We and Where Are We Going?

Baino

Hamzehlou

Kargozar

2018

JFB

370

294

View full text Add to dashboard Cite

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“…Marques et al presented that titanium implants coated with F18 bioactive glass (F18BG) had improved antibiofilm activity in comparison to titanium, especially in the initial periods of biofilm formation by Candida albicans, P. aeruginosa, and S. epidermidis [58]. Recent studies also indicated the application of bioactive glass as a vehicle for the controlled release of therapeutic molecules [59]. Pillararene-based multilayers used for the delivery and release of antibiotics showed similar properties.…”

Section: Alternative Strategies For Combating Bacterial Biofilmsmentioning

confidence: 99%

Bacteriophage-Derived Depolymerases against Bacterial Biofilm

et al. 2021

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In addition to specific antibiotic resistance, the formation of bacterial biofilm causes another level of complications in attempts to eradicate pathogenic or harmful bacteria, including difficult penetration of drugs through biofilm structures to bacterial cells, impairment of immunological response of the host, and accumulation of various bioactive compounds (enzymes and others) affecting host physiology and changing local pH values, which further influence various biological functions. In this review article, we provide an overview on the formation of bacterial biofilm and its properties, and then we focus on the possible use of phage-derived depolymerases to combat bacterial cells included in this complex structure. On the basis of the literature review, we conclude that, although these bacteriophage-encoded enzymes may be effective in destroying specific compounds involved in the formation of biofilm, they are rarely sufficient to eradicate all bacterial cells. Nevertheless, a combined therapy, employing depolymerases together with antibiotics and/or other antibacterial agents or factors, may provide an effective approach to treat infections caused by bacteria able to form biofilms.

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“…Higher loading concentrations usually lead to enhanced drug loading capacity; [122,123] By contrast, some studies indicated that DOX loading capacity of MBGs decreased when the loading concentration increased. [113,114] The drug loading amount depends on the pore size and surface area of MBGs. [110,120,121] The effect of therapeutic ions incorporated in MBGs on the loading capacity has been investigated.…”

Section: Chemotherapeutic Drug Deliverymentioning

confidence: 99%

Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli‐Responsive, Toxicity, Immunogenicity, and Clinical Translation

et al. 2021

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Cancer is one of the top life‐threatening dangers to the human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ago, with applications that include therapeutics as well as diagnostics. A new system within the bioactive glass family, mesoporous bioactive glasses (MBGs), has evolved into a multifunctional platform, thanks to MBGs easy‐to‐functionalize nature and tailorable textural properties—surface area, pore size, and pore volume. Although MBGs have yet to meet their potential in tumor treatment and imaging in practice, recently research has shed light on the distinguished MBGs capabilities as promising theranostic systems for cancer imaging and therapy. This review presents research progress in the field of MBG applications in cancer diagnosis and therapy, including synthesis of MBGs, mechanistic overview of MBGs application in tumor diagnosis and drug monitoring, applications of MBGs in cancer therapy ( particularly, targeted delivery and stimuli‐responsive nanoplatforms), and immunological profile of MBG‐based nanodevices in reference to the development of novel cancer therapeutics.

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Antibacterial and anticancerous drug loading kinetics for (10-x)CuO-xZnO-20CaO-60SiO2-10P2O5 (2 ≤ x ≤ 8) mesoporous bioactive glasses

Cited by 34 publications

References 52 publications

Bioactive Glasses: Where Are We and Where Are We Going?

Bioactive Glasses: Where Are We and Where Are We Going?

Bacteriophage-Derived Depolymerases against Bacterial Biofilm

Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli‐Responsive, Toxicity, Immunogenicity, and Clinical Translation

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