Antibacterial and anticancer potential of marine endophytic actinomycetes Streptomyces coeruleorubidus GRG 4 (KY457708) compound against colistin resistant uropathogens and A549 lung cancer cells

Rajivgandhi, Govindan; Muneeswaran, Thillaichidambaram; Maruthupandy, Muthuchamy; Ramakritinan, C.M.; Saravanan, Konda Mani; Ravikumar, Vasulinga T.; Manoharan, Natesan

doi:10.1016/j.micpath.2018.09.025

Cited by 47 publications

(17 citation statements)

References 44 publications

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“…It hikes day by day and estimated that, about 10,000 new cases annually ( Malvin et al, 2020 ). About World Health Organization (WHO) statement, more than 3000 people will be died in 2019, due to the cigarette smoking, exposure to tobacco usage, physical inactivity and westernized diets ( Rajivgandhi et al, 2018a ). Also, it is a second most leading noncommunicable disease accounted 50% in men and 30% in women ( Rajesh kumar et al, 2018 , Wong et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Anti-cancer activity of biosynthesized silver nanoparticles using Avicennia marina against A549 lung cancer cells through ROS/mitochondrial damages

Tian

Saravanan

Mothana

et al. 2020

Saudi Journal of Biological Sciences

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The biosynthesized Ag NPs was synthesized by using marine mangrove plant extract Avicennia marina . The synthesized Ag NPs was confirmed by various physiochemical characterization including UV-spectrometer and XRD analysis. In addition, the shape and of the synthesized Ag NPs was morphologically identified by SEM initially and TEM finally. After confirmation, the anti-cancer property of synthesized Ag NPs was confirmed at 50 µg/mL concentration against A549 lung cancer cells by MTT assay. Further, the ability to stimulate the ROS generation and mitochondrial membrane at the IC 50 concentration of Ag NPs was confirmed by fluorescence microscopy using DCFH-DA and rhodamine 123 dyes respectively. Finally, the result was concluded that the synthesized Ag NPs has improved anti-cancer activity against A549 cells at lowest concentration.

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Section: Introductionmentioning

confidence: 99%

Anti-cancer activity of biosynthesized silver nanoparticles using Avicennia marina against A549 lung cancer cells through ROS/mitochondrial damages

Tian

Saravanan

Mothana

et al. 2020

Saudi Journal of Biological Sciences

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“…The lethal effect of phthalate derivatives has resulted in the reduction of phytoplankton biomass community, as well as causing the structural changes and decrease of Chl-a concentration at 50%. 35 The DEHP is the most common carcinogenic compounds that may impair neurodevelopment, respiratory, and reproductive systems upon dispersal in the environment. For instance, low birth-weight and retarded growth and development of the placenta occurred in rats treated with DEHP at 125 mg/kg/day.…”

Section: Discussionmentioning

confidence: 99%

Identification of Antibacterial Activity with Bioactive Compounds from Selected Marine Sponges

Kamaruding¹,

Ismail²,

Sokry³

2020

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Background: Marine sponges (phylum Porifera) are sessile filter-feeders from the ocean that are becoming the wealthiest sources of pharmacologically active compounds. Objectives: Our objectives are to identify bioactive compounds from marine sponges (Xestospongia exigua, Xestospongia muta, and Iotrochota baculifera) and to determine their antibacterial activity. Materials and Methods: Methanolic crude extracts were subjected to two-steps fractionation: first, solvent partitioning was conducted using diethyl ether and butanol, followed by column chromatography. The resulting fractions were tested for antibacterial activity against four bacterial strains (Staphylococcus aureus ATCC 25923, Micrococcus luteus ATCC 4698, Escherichia coli ATCC 11775, and Salmonella typhimurium ATCC 14128). The fractions were subsequently profiled using High-Performance Thin Layer Chromatography (HPTLC), and the component of active sub-fractions (SF) was identified using Gas Chromatography-Mass Spectrometry (GC-MS). Results: Although no antibacterial activity was recorded of the methanolic extracts in all marine sponges samples, the response towards diethyl ether extracts of X. exigua was strong. Out of 17 sub-fractions of diethyl ether profiled, three sub-fractions, i.e. 5, 13, and 14 were active. GC-MS identified five compounds in SF 5, four compounds in SF 13, and three compounds in SF 14. Furthermore, SF 13 and SF 14 could inhibit the growth of all bacteria tested, indicating a broad-spectrum activity. On the contrary, SF 5 showed selective inhibition only to E. coli and S. typhimurium, indicating narrow-spectrum activity. Conclusion: Bioactive SF 13 of X. exigua has a high potential as an antibacterial agent but in vitro assessment such as cytotoxicity against mammalian cell lines is needed to determine the toxicity and drug response.

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“…This was performed by following a procedure reported before by ref. 12. Samples freshly washed with water were spread onto freshly prepared sterile nutrient agar media and maintained under room atmosphere conditions for one day.…”

Section: Validation Of Endophytic Actinomycetesmentioning

confidence: 99%

“…Finally, the phylogenetic tree based on the sequence similarities was constructed using the Neighbor-Joining method. 12…”

Section: Genomic Dna Of Endophytic Actinomycetesmentioning

confidence: 99%

Anti-ESBL derivatives of marine endophytic Streptomyces xiamenensis GRG 5 (KY457709) against ESBL producing bacteria

et al. 2022

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Antibacterial and anticancer potential of marine endophytic actinomycetes Streptomyces coeruleorubidus GRG 4 (KY457708) compound against colistin resistant uropathogens and A549 lung cancer cells

Cited by 47 publications

References 44 publications

Anti-cancer activity of biosynthesized silver nanoparticles using Avicennia marina against A549 lung cancer cells through ROS/mitochondrial damages

Anti-cancer activity of biosynthesized silver nanoparticles using Avicennia marina against A549 lung cancer cells through ROS/mitochondrial damages

Identification of Antibacterial Activity with Bioactive Compounds from Selected Marine Sponges

Anti-ESBL derivatives of marine endophytic Streptomyces xiamenensis GRG 5 (KY457709) against ESBL producing bacteria

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