Antibacterial and antibiofilm effects of Pseudomonas aeruginosa derived outer membrane vesicles against Streptococcus mutans

Gurunathan, Sangiliyandi; Thangaraj, Pratheep; Das, Joydeep; Kim, Jin-Hoi

doi:10.1016/j.heliyon.2023.e22606

Cited by 3 publications

(3 citation statements)

References 102 publications

(161 reference statements)

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“…EVs derived from Akkermansia muciniphila reduced fat accumulation, body weight gain, and pathological abnormalities in high-fat diet (HFD)-fed mice; the tested EVs had the most significant effects on adipocyte size, epididymal white adipose tissue (eWAT) weight, lipid balance, and expression of inflammatory cytokines in the adipose tissue and glucose tolerance in diabetic mice. EVs derived from Propionibacterium freudenreichii can mitigate inflammation by modulating the NF-B pathway [ 161 , 164 , 165 , 166 , 167 ].Recently, Gurunathan et al reported that Pseudomonas aeruginosa -derived outer membrane vesicles exhibited antibacterial and antibiofilm effects against Streptococcus mutans. Extracellular nanovesicles produced by Bacillus licheniformis showed anticancer effects against breast and lung cancer cells [ 167 ].…”

Section: Classification Of Postbioticsmentioning

confidence: 99%

“…EVs derived from Propionibacterium freudenreichii can mitigate inflammation by modulating the NF-B pathway [ 161 , 164 , 165 , 166 , 167 ].Recently, Gurunathan et al reported that Pseudomonas aeruginosa -derived outer membrane vesicles exhibited antibacterial and antibiofilm effects against Streptococcus mutans. Extracellular nanovesicles produced by Bacillus licheniformis showed anticancer effects against breast and lung cancer cells [ 167 ].…”

Section: Classification Of Postbioticsmentioning

confidence: 99%

“…As a result, short-chain fatty acids cause cell lysis and enhance membrane permeability in bacteria [ 271 ]. Recently, Gurunathan et al reported that Pseudomonas aeruginosa -derived outer membrane vesicles exhibited antibacterial and antibiofilm effects against Streptococcus mutans [ 167 ]. Antibacterial peptides produced by bacteria exhibit robust antibacterial activity by rupturing microbial membranes and accumulating metabolic nuclei.…”

Section: Antiviral Antibacterial Antioxidants Anticancer and Anti-inf...mentioning

confidence: 99%

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Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases

Gurunathan,

Thangaraj,

Kim

2023

Foods

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Postbiotics are (i) “soluble factors secreted by live bacteria, or released after bacterial lysis, such as enzymes, peptides, teichoic acids, peptidoglycan-derived muropeptides, polysaccharides, cell-surface proteins and organic acids”; (ii) “non-viable metabolites produced by microorganisms that exert biological effects on the hosts”; and (iii) “compounds produced by microorganisms, released from food components or microbial constituents, including non-viable cells that, when administered in adequate amounts, promote health and wellbeing”. A probiotic- and prebiotic-rich diet ensures an adequate supply of these vital nutrients. During the anaerobic fermentation of organic nutrients, such as prebiotics, postbiotics act as a benevolent bioactive molecule matrix. Postbiotics can be used as functional components in the food industry by offering a number of advantages, such as being added to foods that are harmful to probiotic survival. Postbiotic supplements have grown in popularity in the food, cosmetic, and healthcare industries because of their numerous health advantages. Their classification depends on various factors, including the type of microorganism, structural composition, and physiological functions. This review offers a succinct introduction to postbiotics while discussing their salient features and classification, production, purification, characterization, biological functions, and applications in the food industry. Furthermore, their therapeutic mechanisms as antibacterial, antiviral, antioxidant, anticancer, anti-diabetic, and anti-inflammatory agents are elucidated.

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