Antibacterial and anti-inflammatory effects of extracts and fractions from Polygonum capitatum

Evaluation of the impact of Polygonum capitatum, a traditional Chinese herbal medicine, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs

“…This traditional Miao medicinal plant was researched and developed in the 1980s in Guizhou province. Previous pharmacological studies demonstrated that aqueous extracts of Polygonum capitatum, mainly composed of fatty acid esters, triterpenoids, steroids, flavonoids, gallic acid and its analogs, as well as other phenolic compounds (Li and Gong, 2007;Liu et al, 2008;Yu et al, 2008;Yang et al, 2009;Zhang et al, 2010;Zhao et al, 2010;Liao et al, 2011Liao et al, , 2012, possessed antibacterial, anti-inflammatory, hypothermic, analgesic, anti-oxidant and diuretic activities (Ren et al, 1995;Li and Gong, 2007;Liu et al, 2007Liu et al, , 2008Liao et al, 2011). The commercially available Polygonum capitatum products are generally composed of aqueous extracts and for this reason, this type of extract was used in the present study.…”

“…ex D Don] belongs to the Polygonaceae family and is a well-known Miao herb which has been widely used in China for the treatment of various urological disorders, including urinary calculus and urinary tract infections (Editorial Committee of Chinese Materia Medica, 2005). A number of Polygonum capitatum-based drugs (e.g., Relinqing s granules and Milin s capsules) have been approved by the Chinese State Food and Drug Administration (Liao et al, 2011). Both Relinqing s granules and Milin s capsules are made using aqueous extracts of the whole Polygonum capitatum plant, with some other excipients.…”

Identification and Characterisation of Phenolics in Polygonum capitatum by Ultrahigh‐Performance Liquid Chromatography with Photodiode Array Detection and Tandem Mass Spectrometry

“…A number of P. capitatum –based drugs (e.g., Relinqing Granule® and Milin Capsule®) have been approved by the State Food and Drug Administration. Previous investigations have demonstrated that flavonoids, gallic acid and its analogues, and tannins were the major phenolic constituents of P. capitatum (Zhao et al ., ; Liao et al ., ), however, initial ultrahigh‐performance liquid chromatography with photodiode array detection and mass spectrometry (UPLC–PDA–MS) analysis showed that quite a number of phenolic compounds have not yet been identified or characterised, and no peak assignments have been made for any chemical fingerprint of P. capitatum . Identification of the major constituents of the chemical fingerprint of this plant will contribute to the scientific understanding of the chemotaxonomic significance (and possibly the biological effects) of the medicinal plant in the genus Polygonum .…”

2,3-cis-2R,3R-(−)-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell lines

“…The plant genus Fallopia (Polygonacae) is well known in traditional medicines, and extracts have been used to treat hepatitis, liver damage, inflammation, and postmenopausal diseases [1-4]. Compounds isolated from rhizomes of Fallopia sp.…”

“…Compounds isolated from rhizomes of Fallopia sp. have demonstrated vasorelaxant, anti-oxidant, anti-bacterial, anti-inflammatory, and anti-tumor properties [4-7], which have likely led to the Fallopia genus being widely used in traditional Chinese medicines. Several polyphenolic compounds exhibiting estrogenic activity (phytoestrogens) have also been isolated from the roots and rhizomes of numerous Fallopia (recently Polygonum ) species such as F. multiflorum , F. cuspidatum , and F. japonica [8-12].…”