Antibacterial and anti-inflammatory activity of Byrsocarpus coccineus and its constituents

Ahmadu, AA; Haruna, Abdul Kaita; Sule, MI; Pateh, U. U.; ., I.N. Akpulu

doi:10.1055/s-2006-950003

Cited by 2 publications

(3 citation statements)

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“…At the end of these evaluations, these extracts have a low antifungal power [29]. Similarly, in Nigeria, the n-buthanol extract has been shown to be actively against Pseunomonas aeruginosa, Staphylococcus aureus, Escherichia coli and Bacillus subtilis with minimum inhibitory concentrations of 1250 µg/mL to 5000 µg/mL [13]. Our results corroborate these authors' result and justify that the Rourea coccinea leaf has a weak anti-shigella power.…”

Section: The In Vitro Anti-shigella Activity Of Rourea Coccinea Ethan...supporting

confidence: 86%

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Phytochemical screening, antioxidant, antishigella and antileishmanial activities of ethanolic extract of Rourea coccinea (Schumach & Thonn.) Benth leaves

Goueti,

Kpadonou-Kpoviess,

Fatondji

et al. 2023

J. Pure App. Chem Res

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Rourea coccinea is widely used as a medicinal plant in the world, especially in West Africa. The phytochemical screening of ethanolic extract of leaves by applying the Houghton and Raman method with some modifications revealed the presence of alkaloids, phenolic compounds, terpenoids, tannins, coumarins, anthocyanins and anthraquinones. The antiradical test was performed using DPPH (2,2-diphenyl-1-picryhydrazyl), ABTS (2,2-azino-bis (3-ethylbenzo-thiazoline-6-sulfonic acid) diammonium salt) and FRAP (Ferric Reducing Antioxidant Power) with a Scavenging concentration 50 (SC50) of 101.19 µg/mL, 34.73 µg/mL and 88.93 µg/mL respectively. The extract anti-shigella activity determined by the microdilution method was low. According to Jair Siquera-Neto et al., the antileishmanial study using the colorimetric resealing method showed activity against promastigote strains of Leishmania donovani with an inhibitory concentration of IC50=32.26 µg/mL. The traditional use of Rourea coccinea, to treat several diseases, would be justified by these pharmacological property's tests.

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Section: The In Vitro Anti-shigella Activity Of Rourea Coccinea Ethan...supporting

confidence: 86%

“…In Nigeria, this plant's leaf is used to treat fever, sexually transmitted infections, diarrhea, etc. [12], [13]. In Benin, the stem and leaf are used to treat malaria and couple infertility problems [14].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical screening, antioxidant, antishigella and antileishmanial activities of ethanolic extract of Rourea coccinea (Schumach & Thonn.) Benth leaves

Goueti,

Kpadonou-Kpoviess,

Fatondji

et al. 2023

J. Pure App. Chem Res

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“…Preparations of the leaves, roots, and whole plant are used for the treatment of earache, jaundice, and venereal diseases, as a sedative,[ 11 ] and for treating diarrhea, inflammation,[ 12 ] urogenital diseases,[ 13 ] and urinary problems. [ 10 ] Extracts of the plant have been reported to possess molluscidal,[ 14 ] uterotonic,[ 15 ] in vitro antioxidant,[ 16 ] antimicrobial,[ 17 18 ] anti-inflammatory,[ 19 ] hepaprotective and in vivo antioxidant,[ 20 ] and in vitro biological[ 21 ] activities.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effect of Hydroethanolic Leaf Extract of Byrsocarpus coccineus in Alcohol- and Sucrose-Induced Hypertension in Rats

Akindele

Iyamu

Dutt

et al. 2014

Journal of Traditional and Complementary Medicine

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Hypertension remains a major health problem worldwide considering the prevalence of morbidity and mortality. Plants remain a reliable source of efficacious and better tolerated drugs and botanicals. This study was designed to investigate the effect of the chemo-profiled hydroethanolic leaf extract of Byrsocarpus coccineus in ethanol- and sucrose-induced hypertension. Groups of rats were treated orally (p.o.) with distilled water (10 ml/kg), ethanol (35%; 3 g/kg), sucrose (5-7%), and B. coccineus (100, 200, and 400 mg/kg), and nifedipine together with ethanol and sucrose separately for 8 weeks. At the end of the treatment period, blood pressure and heart rate of rats were determined. Blood was collected for serum biochemical parameters and lipid profile assessment, and the liver, aorta, kidney, and heart were harvested for estimation of in vivo antioxidants and malondialdehyde (MDA). Results obtained in this study showed that B. coccineus at the various doses administered reduced the systolic, diastolic, and arterial blood pressure elevated by ethanol and sucrose. Also, the extract reversed the reduction in catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), and superoxide dismutase (SOD) induced by ethanol and sucrose. The level of MDA was reduced compared to the ethanol- and sucrose-induced hypertensive group. With respect to lipid profile, administration of B. coccineus at the various doses reduced the levels of triglycerides, low-density lipoprotein (LDL), cholesterol, and atherogenic indices, compared to the ethanol and sucrose groups. In conclusion the hydroethanolic leaf extract of B. coccineus exerted significant antihypertensive effect and this is probably related to the antioxidant property and improvement of lipid profile observed in this study.

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Antibacterial and anti-inflammatory activity of Byrsocarpus coccineus and its constituents

Cited by 2 publications

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Phytochemical screening, antioxidant, antishigella and antileishmanial activities of ethanolic extract of Rourea coccinea (Schumach & Thonn.) Benth leaves

Phytochemical screening, antioxidant, antishigella and antileishmanial activities of ethanolic extract of Rourea coccinea (Schumach & Thonn.) Benth leaves

Ameliorative Effect of Hydroethanolic Leaf Extract of Byrsocarpus coccineus in Alcohol- and Sucrose-Induced Hypertension in Rats

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