Antibacterial and anti-inflammatory activities of extract and fractions from Pyrrosia petiolosa (Christ et Bar.) Ching

Cheng, Dandan; Zhang, Yingying; Gao, Demin; Hong-meng, Zhang

doi:10.1016/j.jep.2014.07.029

Cited by 24 publications

(18 citation statements)

References 28 publications

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“…Most antibacterial studies have focused on activity of plant extracts, but few on the time-dependent stability of the activity [39]. This indicated the active principles in the ethanol extract and fractions had a relative short shelf life [40]. The leaves of C. dentata and H. indicum used in folk medicine of the population from the northern Colombian coast for the treatment of internal parasites, skin affections as eczema, pruritic ailments, abscess or other inflamed wounds, boils, dermatosis presumably caused by fungal or yeast infections, dry skin condition [3].…”

Section: Mic and Mbc Analysesmentioning

confidence: 99%

Antibacterial activity of Cordia dentata Poir, Heliotropium indicum Linn and Momordica charantia Linn from the Northern Colombian Coast

Ceballos

Hoyos

Estrada

2017

Rev. colomb. cienc. quim. farm.

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SummaryCordia dendata Poir, Heliotropium indicum Linn and Momordica charantia Linn are used for treatment of the most common human diseases and health disorders in folk medicine of the population from the northern Colombian coast. In this study, chemical composition and antibacterial activity of the ethanol extract and fractions from C. dentata, H. indicum and M. charantia were investigated. The chemical constituents of qualitative detection were examined by Thin Layer Chromatography (TLC). The antibacterial activity was determined by agar gel diffusion and broth microdilution method. The main identified compounds were flavonoids, cardiac glycosides, alkaloids, saponins, terpenoids, tannins and coumarins. The minimal inhibitory concentration (MIC) was 31.25 to 1000 g/mL for Gram-positive and Gram-negative bacteria, respectively. These results indicated that ethanol extract and fractions from C. dentata, H. indicum and M. charantia significantly inhibited the growth of standard strains. Potent antibacterial activities of C. dentata, H. indicum and M. charantia may be considered in future study, particularly against antibiotic-resistant cases. Keywords: Cordia dendata

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Section: Mic and Mbc Analysesmentioning

confidence: 99%

Antibacterial activity of Cordia dentata Poir, Heliotropium indicum Linn and Momordica charantia Linn from the Northern Colombian Coast

Ceballos

Hoyos

Estrada

2017

Rev. colomb. cienc. quim. farm.

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“…These free radicals are reduced by flavonoids (Tattini et al, ; Treutter, ). In addition, flavonoids also have anti‐tumor (Falcone Ferreyra et al, ; Middleton, Kandaswami, & Theoharides, ; Russo, Russo, & Spagnuolo, ), anti‐inflammatory (Cheng, Zhang, Gao, & Zhang, ; Cho et al, ), anti‐allergic (Kritas et al, ), anti‐thrombotic (Lee, Ku, & Bae, ), anti‐diabetic (Gaur, Yadav, Verma, Yadav, & Bhakuni, ) and anti‐atherosclerotic activities (Salvamani, Gunasekaran, Shaharuddin, Ahmad, & Shukor, ).…”

Section: Resultsmentioning

confidence: 99%

Proteomic analysis of chickpea roots reveal differential expression of abscisic acid responsive proteins

2019

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Seeds of chickpea are nutritious and alleged to be a preferred source of protein next only to milk. Some of the biotic and abiotic factors reduce chickpea production worldwide. Plant roots are the first to perceive stress signals. The wild root free radical scavenging activity measured by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) method was 28.06 ± 1.43% and 25.12 ± 0.95% in cultivated chickpea type. The root proteins were resolved on 7 cm IPG strip having a pH gradient 5–8 and subsequently separated on the basis of mass using SDS–PAGE in second dimension. A total of eight representative spots were subjected for identification by MALDI‐TOF‐MS. A protein‐protein association network analysis using STRING software permitted to build an interactomic map of all detected proteins, characterised by 16 interactions. The findings may provide a better understanding of the biochemical mechanism of different root pathways and stress‐responses in chickpea. Practical applications Information pertaining to stress resistance is essential from breeder’s perspectives. Chickpea is prone to high yield losses due to recurring droughts. MALDI‐TOF‐MS coupled with MASCOT query search found significant correlations with abscisic acid responsive proteins associated to drought stress using comparative proteomics. This report will assist researchers a ready reference for executing further studies concerning chickpea root proteins. The findings may provide a better understanding of the biochemical mechanism of different root pathways and stress‐responses in chickpea.

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“…Formalin test was used to evaluate the analgesic effect of the brucine gel [26]. It was shown that the earlier phase of formalin-induced pain reflected formalin direct irritation to mice in the recent studies.…”

Section: Resultsmentioning

confidence: 99%

A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities

Qin

Feng

et al. 2017

IJMS

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The seeds of Strychnos nux-vomica L., as a traditional Chinese medicine, have good anti-inflammatory and analgesic activities. However, it usually leads to gastrointestinal irritation and systemic toxicity via oral administration. In the study, it was discovered that a novel gel transdermal delivery system contained brucine, the main effective component extracted from Strychnos nux-vomica. Results showed that the brucine gel system inhibited arthritis symptoms and the proliferation of the synoviocytes in the rat adjuvant arthritis model, which indicated its curative effect for rheumatoid arthritis. Meanwhile, it significantly relieved the xylene-induced ear edema in the mouse ear swelling test, which manifested its anti-inflammatory property. Moreover, the brucine gel eased the pain of paw formalin injection in the formalin test, which demonstrated its analgesic effects. In addition, the brucine significantly inhibited lipopolysaccharide (LPS)-induced Prostaglandin E2 (PGE2) production without affecting the viability of cell in vitro anti-inflammatory test, which proved that its anti-inflammatory and analgesic actions were related to inhibition of prostaglandin synthesis. It is suggested that the brucine gel is a promising vehicle for transdermal delivery on the treatment of inflammatory disease.

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Antibacterial and anti-inflammatory activities of extract and fractions from Pyrrosia petiolosa (Christ et Bar.) Ching

Cited by 24 publications

References 28 publications

Antibacterial activity of Cordia dentata Poir, Heliotropium indicum Linn and Momordica charantia Linn from the Northern Colombian Coast

Antibacterial activity of Cordia dentata Poir, Heliotropium indicum Linn and Momordica charantia Linn from the Northern Colombian Coast

Proteomic analysis of chickpea roots reveal differential expression of abscisic acid responsive proteins

A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities

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