Antibacterial and anti-inflammatory activities of cardamom (Elettaria cardamomum) extracts: Potential therapeutic benefits for periodontal infections

Souissi, M.; Azelmat, Jabrane; Chaieb, Kamel; Grenier, Daniel

doi:10.1016/j.anaerobe.2019.102089

Cited by 69 publications

(45 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of C3G was expressed in a dose-dependent manner, and the biofilm inhibitory effect in the bronchial tube was also recognized by SEM analysis. As there are several reports of potential antibiofilm candidate drugs against P. gingivalis such as the fruit and seed of Elettaria cardamomum , resveratrol, azithromycin, carvacrol and terpinen-4-ol, and curcumin [26–30], there are no established antibiofilm drugs for inhibiting biofilm formation of P. gingivalis in western medicine. These results suggest that LCEE treatment would be more beneficial for antibiofilm formation therapy of P. gingivalis as well as plaque control.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lonicera caerulea var. emphyllocalyx Fruit on Biofilm Formed by Porphyromonas gingivalis

Minami

Takase

Nakamura

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

Porphyromonas gingivalis is an important pathogenic anaerobic bacterium that causes aspiration pneumonia. This bacterium frequently forms biofilms in the oral cavity and in respiratory tract-associated medical devices. Bacterial colonization that occurs in association with this biofilm formation is the main reason for incurable aspiration pneumonia. The Lonicera caerulea var. emphyllocalyx (LCE) fruit has been used in folk medicine in Hokkaido, the northern part of Japan. The aim of this study was to elucidate one of the antimicrobial mechanisms of LCE methanol extract (LCEE)—the inhibitory effect of LCEE on biofilm formation by P. gingivalis. Our results show that LCEE significantly reduced biofilm formation by three different P. gingivalis isolates in a concentration- and time-dependent manner that were quantified by the adsorption of safranin red. When LCEE was added to biofilms already formed by P. gingivalis, LCEE did not degrade the biofilm. However, treatment with LCEE significantly promoted the removal of existing biofilm by vibration compared to that of control. We also confirmed biofilm formation in LCEE-treated P. gingivalis in tracheal tubes using scanning electron microscopic (SEM) analysis. Cyanidin 3-O-glucoside (C3G), one of the components of LCE, also inhibited the formation of biofilm by P. gingivalis in a concentration-dependent manner. Our results reveal that LCEE may be an effective antibacterial substance for P. gingivalis-induced aspiration pneumonia because of its role in the suppression of bacterial biofilm formation in the oral cavity.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Lonicera caerulea var. emphyllocalyx Fruit on Biofilm Formed by Porphyromonas gingivalis

Minami

Takase

Nakamura

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Cardamom is an effective immunomodulatory agent due to its anti-inflammatory effects. It is capable of downregulating pro-inflammatory cytokines (Figure 5b) [108]; suppressing T helper (TH)1 cytokine release and enhancing Spices-Reservoir of Health Benefits DOI: http://dx.doi.org/10.5772/intechopen.96471 T helper (TH)2 cytokine release [109]. Methanol and petroleum ether extract of cardamom reduced 70% and 50% lesions in ethanol-induced ulcer mice model at 500 mg/kg and 100 mg/kg respectively exhibiting gastroprotective effects [110].…”

Section: Cardamommentioning

confidence: 99%

“…A constituent of cardamom, cardamonin inhibited the formation of new cancer stem cells in case of breast cancer by effectively suppressing the up-regulation of IL-8 and, MCP-1 cytokines and activation of NF-κB pathway [111]. Antibacterial effects of cardamom has also been demonstrated [108,112].…”

Section: Cardamommentioning

confidence: 99%

Spices-Reservoir of Health Benefits

Sachdeva¹,

Kaushik²

2022

Natural Medicinal Plants

View full text Add to dashboard Cite

Spices contribute to the quality, nutritive value, and flavor of food. Since ancient times, they hold a great medicinal value. Their antimicrobial, antiviral, antibacterial, anti-inflammatory, and other numerous properties have made them a potent source of therapeutic agents. Phytochemical analysis revealed presence of active constituents such as eugenol, curcumin, carotenoids in clove, turmeric, saffron respectively that explains the efficacious nature of these spices. Owing to their easy availability and consumption, it is advised to make spices daily part of our diet though in balanced amount as sometimes excess usage bear few consequences. Evaluating multiple benefits offered by these as immunity boosters especially in times of pandemic and incorporating them in our routine diet would improve disease management strategies. This chapter discusses the reservoir of activities exhibited by few spices along with the components responsible for these activities. Here, we also discussed their negative effects if at all.

show abstract

“…The ethyl acetate fraction from the leaves of Schismus fasciculatus contained kaempferol, quercetin, and agathist flavone, which showed moderate antibacterial activity against different tested strains (IC 50 0.9 mg/mL) [44]. In addition, both cardamom (Elettaria cardamomum) fruit and seed extracts exerted remarkable antibacterial effect against Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, and Prevotella intermedia [45].…”

Section: Ofmentioning

confidence: 99%

Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties

et al. 2021

View full text Add to dashboard Cite

Site-Specific release of active molecules with antimicrobial activity spurred the interest in the development of innovative polymeric nanocarriers. In the preparation of polymeric devices, nanotechnologies usually overcome the inconvenience frequently related to other synthetic strategies. High performing nanocarriers were synthesized using a wide range of starting polymer structures, with tailored features and great chemical versatility. Over the last decade, many antimicrobial substances originating from plants, herbs, and agro-food waste by-products were deeply investigated, significantly catching the interest of the scientific community. In this review, the most innovative strategies to synthesize nanodevices able to release antimicrobial natural extracts were discussed. In this regard, the properties and structure of the starting polymers, either synthetic or natural, as well as the antimicrobial activity of the biomolecules were deeply investigated, outlining the right combination able to inhibit pathogens in specific biological compartments.

show abstract

Antibacterial and anti-inflammatory activities of cardamom (Elettaria cardamomum) extracts: Potential therapeutic benefits for periodontal infections

Cited by 69 publications

References 26 publications

Effect of Lonicera caerulea var. emphyllocalyx Fruit on Biofilm Formed by Porphyromonas gingivalis

Effect of Lonicera caerulea var. emphyllocalyx Fruit on Biofilm Formed by Porphyromonas gingivalis

Spices-Reservoir of Health Benefits

Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties

Contact Info

Product

Resources

About