Antibacterial and anti-biofilm effects of a polyherbal formula and its constituents against coagulase-negative and -positive staphylococci isolated from bovine mastitis

Chusri, Sasitorn; Tongrod, Sirirat; Saising, Jongkon; Mordmuang, Auemphon; Limsuwan, Surasak; Sanpinit, Sineenart; Voravuthikunchai, Supayang Piyawan

doi:10.1080/09712119.2016.1193021

Cited by 17 publications

(9 citation statements)

References 38 publications

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“…In context of AMR, the infectious microbes may find it difficult to develop resistance against a multi-component polyherbal formulation, than against a single antibiotic molecule, because in a poly-component formulation there are likely to be multiple compounds exerting antimicrobial action targeting more than one component of bacterial cellular machinery. This may be a reason why the ancient medicinal practises has relied on polyherbal formulations like PF or Ya-Sa-Marn-Phlae (YSMP) for treatment of infections [37] .…”

Section: Discussionmentioning

confidence: 99%

Anti-infective potential of a quorum modulatory polyherbal extract (panchvalkal) against certain pathogenic bacteria

Patel

Joshi

Palep

et al. 2020

Journal of Ayurveda and Integrative Medicine

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Background In view of the gravity of the problem of antimicrobial resistance among pathogenic bacteria against conventional bactericidal agents, investigation on alternative approaches to combat bacterial infections is warranted. Objective Current study aimed at investigating anti-infective potential of a polyherbal ayurvedic formulation namely panchvalkal against three different pathogenic bacteria. Materials and methods The panchvalkal formulation available as Pentaphyte P5® was tested for its possible in vitro quorum-modulatory potential against Chromobacterium violaceum , Serratia marcescens , and Staphylococcus aureus through broth dilution assay. In vivo efficacy was demonstrated employing Caenorhabditis elegans as the model host for test pathogens. Results This formulation was found to exert quorum-modulatory effect on C. violaceum , S. marcescens , and S. aureus at 250–750 μg/ml. Besides altering production of the quorum sensing-regulated pigments in these bacteria, the test formulation also had in vitro effect on antibiotic susceptibility, catalase activity and haemolytic potential of the pathogens. In vivo assay confirmed the protective effect of this panchvalkal formulation on C. elegans, when challenged with the pathogenic bacteria. Repeated exposure of S. aureus to panchvalkal did not induce resistance in this bacterium. Conclusion To the best of our awareness, this the first report on quorum-modulatory potential of panchvalkal formulation, validating the anti-infective potential and moderate prebiotic property of this polyherbal preparation.

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Section: Discussionmentioning

confidence: 99%

Anti-infective potential of a quorum modulatory polyherbal extract (panchvalkal) against certain pathogenic bacteria

Patel

Joshi

Palep

et al. 2020

Journal of Ayurveda and Integrative Medicine

View full text Add to dashboard Cite

show abstract

“…In context of AMR, the infectious microbes may find it difficult to develop resistance against a multi-component polyherbal formulation, than against a single antibiotic molecule, because in a poly-component formulation there are likely to be multiple compounds exerting antimicrobial action targeting more than one component of bacterial cellular machinery. This may be a reason why the ancient medicinal practices has relied on polyherbal formulations like PF or Ya-Sa-Marn-Phlae (YSMP) for treatment of infections [35].…”

Section: Discussionmentioning

confidence: 99%

Anti-infective potential of a quorum modulatory polyherbal extract (Panchvalkal) against certain pathogenic bacteria

Patel

Joshi

Palep

et al. 2017

Preprint

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Anti-infective potential of a polyherbal ayurvedic formulation namely panchvalkal was assayed against three pathogenic bacteria. This formulation was found to exert quorum-modulatory effect on Chromobacterium violaceum, Serratia marcescens, and Staphylococcus aureus at 250-750 µg/mL. Besides altering production of the quorum sensing-regulated pigments in these bacteria, the test formulation also had in vitro effect on antibiotic susceptibility, catalase activity and hemolytic potential of the pathogens. In vivo assay confirmed the protective effect of this panchvalkal formulation on Caenorhabditis elegans, when challenged with the pathogenic bacteria. Repeated exposure of S. aureus to panchvalkal did not induce resistance in this bacterium. To the best of our awareness, this the first report on quorum-modulatory potential of panchvalkal formulation, validating the anti-infective potential and moderate prebiotic property of this polyherbal preparation.

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“…Negi and co-workers (Negi & Dave, 2010) (Chusri et al, 2017). In a study by Shafi Thompson and co-workers, the antibacterial activity of different organic extracts of A. catechu was assayed against several bacteria responsible of dental caries (Shafi Thompson et al, 2011).…”

Section: In Vitro Antimicrobial Activitymentioning

confidence: 99%

Areca catechu—From farm to food and biomedical applications

Salehi

Konovalov

Fru

et al. 2020

Phytotherapy Research

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The family Arecaceae includes 181 genera and 2,600 species with a high diversity in physical characteristics. Areca plants, commonly palms, which are able to grow in nearly every type of habitat, prefer tropical and subtropical climates. The most studied species Areca catechu L. contains phytochemicals as phenolics and alkaloids with biological properties. The phenolics are mainly distributed in roots followed by fresh unripe fruits, leaves, spikes, and veins, while the contents of alkaloids are in the order of roots, fresh unripe fruits, spikes, leaves, and veins. This species has been reputed to provide health effects on the cardiovascular, respiratory, nervous, metabolic, gastrointestinal, and reproductive systems. However, in many developing countries, quid from this species has been associated with side effects, which include the destruction of the teeth, impairment of oral hygiene, bronchial asthma, or oral cancer. Despite these side effects, which are also mentioned in this work, the present review collects the main results of biological properties of the phytochemicals in A. catechu. This study emphasizes the in vitro and in vivo antioxidant, antimicrobial, anticancer, and clinical effectiveness in humans. In this sense, A. catechu have demonstrated effectiveness in several reports through in vitro and in vivo experiments on disorders such as antimicrobial, antioxidant, or anticancer. Moreover, our findings demonstrate that this species presents clinical effectiveness on neurological disorders. Hence, A. catechu extracts could be used as a bioactive ingredient for functional food, nutraceuticals, or cosmeceuticals. However, further studies, especially extensive and comprehensive clinical trials, are recommended for the use of Areca in the treatment of diseases.

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Antibacterial and anti-biofilm effects of a polyherbal formula and its constituents against coagulase-negative and -positive staphylococci isolated from bovine mastitis

Cited by 17 publications

References 38 publications

Anti-infective potential of a quorum modulatory polyherbal extract (panchvalkal) against certain pathogenic bacteria

Anti-infective potential of a quorum modulatory polyherbal extract (panchvalkal) against certain pathogenic bacteria

Anti-infective potential of a quorum modulatory polyherbal extract (Panchvalkal) against certain pathogenic bacteria

Areca catechu—From farm to food and biomedical applications

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