Antibacterial activity of various chitosan forms against Xanthomonas axonopodis pv. glycines

Moon, Chaeyeong; Seo, Dong‐Jun; Song, Yuanlin; Jung, Woo‐Jin

doi:10.1016/j.ijbiomac.2019.11.211

Cited by 14 publications

(13 citation statements)

References 31 publications

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“…The mechanisms of the antimicrobial activity of CS involve electrostatic interactions between the positively charged chitosan chains and bacterial cell membrane, affecting cell permeability and leading to bacterial death [12]. Membrane damage, interaction with DNA/RNA, metal chelation and deposition on the microbial surface are also other possible chitosan antimicrobial mechanisms reported [52]. In this work, the antibacterial activity exhibited by the studied ABCs is enhanced by the presence of GO which presents antibacterial mechanisms due to its extremely sharp edges that cause physical damage to the bacterial membrane [49,50].…”

Section: Antibacterial Activity Against Escherichia Colimentioning

confidence: 99%

Osseointegration of Antimicrobial Acrylic Bone Cements Modified with Graphene Oxide and Chitosan

et al. 2020

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Acrylic bone cement (ABC) is one of the most used materials in orthopedic surgery, mainly for the fixation of orthopedic implants to the bone. However, ABCs usually present lack of biological activity and osseointegration capacity that leads to loosening of the prosthesis. This work reports the effect of introducing graphene oxide (GO) and chitosan (CS), separately or together, in the ABC formulation on setting performance, mechanical behavior, and biological properties. Introduction of both CS and GO to the ABC decreased the maximum temperature by 21% and increased the antibacterial activity against Escherichia coli by 87%, while introduction of only CS decreased bending strength by 32%. The results of cell viability and cell adhesion tests showed in vitro biocompatibility. The in vivo response was investigated using both subdermal and bone parietal implantations in Wistar rats. Modified ABCs showed absence of immune response, as confirmed by a normal inflammatory response in Wistar rat subdermal implantation. The results of the parietal bone implantation showed that the addition of CS and GO together allowed a near total healing bone–cement interface, as observed in the micrographic analysis. The overall results support the great potential of the modified ABCs for application in orthopedic surgery mainly in those cases where osseointegration is required.

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Section: Antibacterial Activity Against Escherichia Colimentioning

confidence: 99%

Osseointegration of Antimicrobial Acrylic Bone Cements Modified with Graphene Oxide and Chitosan

et al. 2020

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“…Xag can be spread by rain droplets during the growing season and by seed transportation 7 . A number of spreads of bacterial pustule disease have taken place in Asia during recent years, reducing the size and quantity of the seeds 8,9 …”

Section: Introductionmentioning

confidence: 99%

“…7 A number of spreads of bacterial pustule disease have taken place in Asia during recent years, reducing the size and quantity of the seeds. 8,9 Flavonoids rutin and genistein have been directly related to the defence mechanism of soybean to Xag, and soybean resistant varieties are known to produce higher amounts of flavonoids in comparison with susceptible varieties. 10,11 Although soybean has been reported to produce Biochanin A, the concentration of this isoflavonoid is under the quantification limits, indicating that soybean can synthesize Biochanin A only in very low concentration.…”

Section: Introductionmentioning

confidence: 99%

“…Only one report can be found in the literature examining the antimicrobial properties of Biochanin A against plant fungal pathogens Rhizoctonia solani and Sclerotium rolfsii. 20 Some pesticides, such as chloromycetin and copper oxychloride, 8 have been widely used for the management of Xag. Although the mentioned pesticides have shown negative effects to human health and environment, 21 and new Xag resistant strains have been reported.…”

Section: Introductionmentioning

confidence: 99%

“…Some pesticides, such as chloromycetin and copper oxychloride, 8 have been widely used for the management of Xag . Although the mentioned pesticides have shown negative effects to human health and environment, 21 and new Xag resistant strains have been reported 22 .…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial mechanism of Biochanin A and its efficacy for the control of Xanthomonas axonopodispv.glycines in soybean

Shi

et al. 2020

Pest Management Science

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BACKGROUND Xanthomonas axonopodis pv. glycines (Xag) is a hazardous pathogen able to cause bacterial pustule disease in soybean, reducing crop yield and quality. Although flavonoids rutin and genistein are known to play an important role in soybean defence, soybean is only able to produce Biochanin A in low concentration. RESULTS In this work, Biochanin A was found to produce higher antibacterial activity against Xag in comparison with genistein (minimum inhibitory concentration < 100 μg/mL). Biochanin A was able to inhibit DNA synthesis and flagella formation in Xag, and altered the composition of the bacterial membrane. These effects reduced swimming motility, extracellular protease activity and biofilm formation. Further, Biochanin A was tested for the control of Xag in soybean leaves, showing similar, or even higher, inhibitory ability in comparison with some products commonly used for the control of this pathogen. CONCLUSIONS The antibacterial properties of Biochanin A against Xag have been studied for the first time, revealing new insights on the potential applications of this isoflavonoid for the management of bacterial pustule disease. © 2020 Society of Chemical Industry

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Reimagining Chitosan‐Based Antimicrobial Biomaterials to Mitigate Antibiotic Resistance and Alleviate Antibiotic Overuse: A Review

Dhlamini,

Selepe,

Ramalapa

et al. 2024

Macro Materials & Eng

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This paper reports recent advancements in chitosan‐based antimicrobial biomaterials that aim to address the issue of antimicrobial resistance (AMR). Today, AMR is one of the most significant public health challenges the world is facing. To combat the overuse of antibiotics, a range of materials, including advanced nanosized polymers, have been explored as potential antimicrobial agents. In this direction, chitosan scores highly because of its unique combination of properties such as biodegradability, biocompatibility, bioactivity, non‐toxic, and, most importantly, its intrinsic antibacterial and antifungal activity. Herein, an overview of chitosan and its derivatives as potential alternatives to conventional antimicrobial therapeutics is reported. This review starts with understanding the AMR mechanism, which is critical for developing suitable materials for treating infectious diseases. Then, the inherent characteristics, modes of antimicrobial action, and factors that impact the antimicrobial effectiveness of chitosan and its derivatives are discussed. The authors further summarize various clinical trial results of chitosan‐based materials as antimicrobial agents. Finally, various antimicrobial applications of chitosan‐based materials are reported. In summary, this review offers new insights into the design of chitosan‐based sustainable materials for various antimicrobial applications.

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Antibacterial activity of various chitosan forms against Xanthomonas axonopodis pv. glycines

Cited by 14 publications

References 31 publications

Osseointegration of Antimicrobial Acrylic Bone Cements Modified with Graphene Oxide and Chitosan

Osseointegration of Antimicrobial Acrylic Bone Cements Modified with Graphene Oxide and Chitosan

Antibacterial mechanism of Biochanin A and its efficacy for the control of Xanthomonas axonopodispv.glycines in soybean

Reimagining Chitosan‐Based Antimicrobial Biomaterials to Mitigate Antibiotic Resistance and Alleviate Antibiotic Overuse: A Review

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