Antibacterial Activity of The Iron-Zinc Oxide Nanoparticles Synthesized Via Electric Discharge Method

Abstract

With the increase in diseases caused by bacterial and viral infections, the need for antibiotics has increased. On the other hand, by creating drug resistance to organicmoietiesbased antibiotics, novel antibiotics have attracted the attention of researchers.Nano-scale metal oxides are increasingly being considered for medical applications, especially as antibacterial agents.In this study, iron oxide nanoparticles (IONPs) and zinc oxide nanoparticles (ZONPs) were prepared via electrical discharge method in liquid medium by changing parameters such as wire diameter and electric current intensity. Synthesized NPs were evaluated by XRD, UV_Visible, FE_SEM, EDS, HR_TEM and TEM analyzes. Also, the antibacterial properties of these nanoparticles were evaluated in different ways against gram-positive and gram-negative bacteria.

Influence of Physicochemical Properties of Iron Oxide Nanoparticles on Their Antibacterial Activity

“…Diverse-shaped IONPs utilize different approaches to interact with bacteria; hexagonal IONPs are larger compared to spherical ones. As a result, the hexagonal IONPs interact with the bacterial cell wall due to their sharp edges, which results in cell wall distortion. , However, the spherical-shaped IONPs could diffuse into the intercellular space. Additionally, there is empirical evidence that displays this particular variant is not effective against all types of bacteria. − A study revealed that nanoparticles with a spherical shape exhibit the highest level of effectiveness in combating bacterial infections .…”

“…As a result, the hexagonal IONPs interact with the bacterial cell wall due to their sharp edges, which results in cell wall distortion. 166,167 However, the spherical-shaped IONPs could diffuse into the intercellular space. Additionally, there is empirical evidence that displays this particular variant is not effective against all types of bacteria.…”