Antibacterial activity of some saturated polyoxotungstates

Grama, Lavinia; Man, Adrian; Muntean, Daniela-Lucia; Florea, Șerban Andrei Gâz; Boda, Francisc; Curticăpean, Augustin

doi:10.2478/rrlm-2014-0007

Cited by 6 publications

(6 citation statements)

References 28 publications

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“…These particular pathogens are also part of a wider global problem—increasing microbial resistance against antibiotics—that can lead to public healthcare crises and uncontrolled spread of infectious diseases . Although the antibacterial effects of classical POMs have been reported previously, to the best of our knowledge, this is the first systematic study on the antimicrobial activity of POM‐ILs.…”

Section: Resultsmentioning

confidence: 86%

“…Remarkably, the Gram‐positive bacterium S. aureus was especially sensitive to all types of POM‐IL tested and MIC values as low as 2–10 mg L −1 were observed. Thus, the POM‐ILs reported are significantly more potent antimicrobials than the POMs studied so far, for which MIC values for S. aureus typically were greater than 400 mg L −1 (reported for several polyoxotungstates against various strains of S. aureus ; Table ) . These initial data suggest that POM‐ILs are promising new antimicrobials against S. aureus and possibly other Gram‐positive bacteria that can rapidly develop resistance to antibiotics, leading to so‐called “superbugs” such as methicillin‐resistant S. aureus (MSRA) …”

Section: Resultsmentioning

confidence: 97%

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Antimicrobial Activity of Polyoxometalate Ionic Liquids against Clinically Relevant Pathogens

et al. 2017

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The activity of a new class of antimicrobials—polyoxometalate ionic liquids (POM‐ILs)—is systematically investigated. The prototype POM‐ILs feature Keggin‐type anions (α‐SiW11O398−) and tetraalkylammonium ions as active cationic species. Antimicrobial tests of the POM‐ILs against important human pathogens show that variation of the alkyl chain length of the cation leads to significant changes in antimicrobial activity against the medically relevant Gram‐negative bacteria Escherichia coli and Pseudomonas aeruginosa, and especially against the Gram‐positive Staphylococcus aureus. Owing to the unique materials properties of the POM‐ILs, such as high viscosity and water immiscibility, applications of antimicrobial surface coatings against airborne pathogens or for water decontamination can be envisaged. Furthermore, the combination of antimicrobially active cations with POM anions might afford new POM‐ILs with two active components.

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Section: Resultsmentioning

confidence: 86%

Section: Resultsmentioning

confidence: 97%

Antimicrobial Activity of Polyoxometalate Ionic Liquids against Clinically Relevant Pathogens

et al. 2017

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“…Thus, because of their safety and selectivity, these nanocomposite films display great potential as antimicrobial coatings for the food preservation. Polyoxometalates (POM) are anionic clusters of metal oxides with remarkable physicochemical properties such as high thermal resistivity and water solubility [217] as well as interesting antibacterial properties [218,219]. Moghayedi et al [220] fabricated rGo-phosphomolybdic acid (H 3 PMo 12 O 40 ) (rGO-P-Mo) using the hydrothermal reduction method and evaluated the antibacterial activity against E. coli using colony counting and the micro-dilution method.…”

Section: Multicomponent Composite Functionalizationmentioning

confidence: 99%

Antibacterial Properties of Graphene-Based Nanomaterials

et al. 2019

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Bacteria mediated infections may cause various acute or chronic illnesses and antibiotic resistance in pathogenic bacteria has become a serious health problem around the world due to their excessive use or misuse. Replacement of existing antibacterial agents with a novel and efficient alternative is the immediate demand to alleviate this problem. Graphene-based materials have been exquisitely studied because of their remarkable bactericidal activity on a wide range of bacteria. Graphene-based materials provide advantages of easy preparation, renewable, unique catalytic properties, and exceptional physical properties such as a large specific surface area and mechanical strength. However, several queries related to the mechanism of action, significance of size and composition toward bacterial activity, toxicity criteria, and other issues are needed to be addressed. This review summarizes the recent efforts that have been made so far toward the development of graphene-based antibacterial materials to face current challenges to combat against the bacterial targets. This review describes the inherent antibacterial activity of graphene-family and recent advances that have been made on graphene-based antibacterial materials covering the functionalization with silver nanoparticles, other metal ions/oxides nanoparticles, polymers, antibiotics, and enzymes along with their multicomponent functionalization. Furthermore, the review describes the biosafety of the graphene-based antibacterial materials. It is hoped that this review will provide valuable current insight and excite new ideas for the further development of safe and efficient graphene-based antibacterial materials.

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“…The spectroscopic change suggests that there are interactions between PMo 10 V 2 and ctDNA. The titration absorption data were analyzed to evaluate the intrinsic binding constant , which can be calculated based on (2), which was given by the ratio of slope to the intercept in plots from the equation. As shown in the inset Concentration ( g/mL)…”

Section: Dna Bindingmentioning

confidence: 99%

“…The current interest in polyoxometalates (POMs) keeps on increasing worldwide, not only because of their enormous structural variety, but also their potential applications in multitudinal fields such as catalysis, medicine, and functional materials [1,2]. Especially, the medicinal properties of POMs have been a subject of interest in drug discovery.…”

Section: Introductionmentioning

confidence: 99%

In VitroAntitumor Activity of a Keggin Vanadium-Substituted Polyoxomolybdate and Its ctDNA Binding Properties

Qin²,

Guo

et al. 2015

Journal of Chemistry

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A Keggin vanadium-substituted polyoxomolybdate, K 5 PMo 10 V 2 O 40 (PMo 10 V 2 ), has been synthesized and it's antitumor effect against Hela cells was investigated. The calf thymus DNA (ctDNA) binding ability of PMo 10 V 2 was also evaluated by UV-Vis absorption spectra and fluorescence spectra. The identity and high purity of PMo 10 V 2 was confirmed by elemental analysis and IR analysis. And the antitumor activity test of PMo 10 V 2 was carried out on Hela cancer cells line by MTT assay. The results of MTT assay show that PMo 10 V 2 significantly reduced the viability of Hela cells in a dose-dependent manner and exhibited stronger inhibitory activity against Hela cells at an IC 50 of 800 g/mL, which is more effective than the positive control, 5-Fu ( < 0.05). The results of the UV-Vis absorption spectra and fluorescence spectra indicated the groove or outside stacking binding between PMo 10 V 2 and ctDNA. These results show that the antitumor activity of PMo 10 V 2 may be caused by the interactions between DNA and PMo 10 V 2 .

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Antibacterial activity of some saturated polyoxotungstates

Abstract: Polyoxometalates are important inorganic compounds with a broad range of pharmacological properties, including antiviral, antibacterial, antiprotozoal

Cited by 6 publications

References 28 publications

Antimicrobial Activity of Polyoxometalate Ionic Liquids against Clinically Relevant Pathogens

Antimicrobial Activity of Polyoxometalate Ionic Liquids against Clinically Relevant Pathogens

Antibacterial Properties of Graphene-Based Nanomaterials

In VitroAntitumor Activity of a Keggin Vanadium-Substituted Polyoxomolybdate and Its ctDNA Binding Properties

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