Antibacterial Activity of Selected Beta-Lactam and Aminoglycoside Antibiotics Against Cephalothin-Resistant Enterobacteriaceae

Abstract

The in vitro antibacterial activity of four 18-lactam antibiotics (cefatrizine

In Vitro Susceptibility of Gentamicin-Resistant Enterobacteriaceae and Pseudomonas aeruginosa to Netilmicin and Selected Aminoglycoside Antibiotics

“…The high degree of in vitro activity of amikacin against gentamicin-resistant Enterobacteriaceae and P. aeruginosa agrees with our previous findings reported in a smaller number of different clinical isolates (8,12). Although gentamicin and tobramycin are active against some strains ofProvidencia (7), our experience agrees with that of Overturf et al, who found gentamicin-resistant strains that were susceptible to amikacin (14).…”

“…Resistance to gentamicin among the Enterobacteriaceae and Pseudomonas aeruginosa appears to be a problem of increasing importance (5,12). At the Wadsworth VA Hospital amikacin was shown to be the most effective aminoglycoside in vitro against gentamicin-resistant Enterobacteriaceae and P. aeruginosa (8,12). Likewise, it has been highly effective in treating infections caused by gentamicin-resistant, gram-negative bacilli (11).…”

“…Early clinical investigation with netilmicin indicates that the blood levels achieved are equal to or greater than those achieved with gentamicin, which it closely resembles pharmacologically (L. S. Young, personal communication, 1976). This study was designed to compare the in vitro effectiveness ofnetilmicin with other aminoglycosides currently licensed or under clinical investigation, i.e., amikacin (8,9,11,12,15,19,20), sisomicin (8,9,20), and tobramycin (8,9,13,20 (6,10). Freezethaw extraction of the agar media was performed.…”

“…Only organisms with a gentamicin MIC :16 ,ug/ml in agar dilution testing or . 8 ,ug/ml in broth dilution testing were included.…”

Comparison of the Antibacterial Activity of Nine Cephalosporins Against Enterobacteriaceae and Nonfermentative Gram-Negative Bacilli

“…However, recently a number of new cephalosporins have been synthesized that seem to have a markedly broader spectrum against gram-negative bacilli. Among the most promising are cefamandole (2,4,5,7,10), cefuroxime (5,11,12), cefatrizine (6,7,13,15), cefoxitin (3, 7-9, 11, 14), and cefazaflur (SKF 59962) (1).…”