Antibacterial Activity of Propolis-Embedded Zeolite Nanocomposites for Implant Application

Son, Jun Sik; Hwang, Eun Ju; Kwon, Lee Seong; Ahn, Yong-Gook; Moon, Byung-Kwon; Kim, Jin; Kim, Douk Hoon; Kim, Su Gwan; Lee, Sook-Young

doi:10.3390/ma14051193

Cited by 13 publications

(15 citation statements)

References 48 publications

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“…One of the main characteristics attributed to propolis in the literature is its antimicrobial action 13,15,25,29,30 . The oral environment is populated by a multi-species ecosystem.…”

Section: Discussionmentioning

confidence: 99%

“…Among the engineering of mineralized dental tissues, the prolonged release of propolis over a month indicated that it can long-term inhibition of these dental pathogens in implants according to Son et al, 2021 25 . One of the compounds responsible for the antimicrobial action of propolis, cinnamic acid derivatives showed good stability in orally disintegrating lms over twelve weeks.…”

Section: Discussionmentioning

confidence: 99%

“…Chlorhexidine was the most commonly found substance in three studies. Only the study by Son et al, 2021 25 did not report the sample size, all the others detailed this information. The study about animal model did not report the sample size calculation, despite reporting that they followed international protocol for studies in animal models.…”

Section: Characteristics Of the Articles Includedmentioning

confidence: 99%

“…In studies involving periodontal 26-28 and endodontic 9,21 diseases, formulations containing it indicate a potential bene cial anti-in ammatory and antimicrobial effect. Some studies show the antimicrobial activity of propolis against Gram-positive 24,27 and Gram-negative bacteria 27 , especially Streptococcus mutans 15,25,29 , in addition to its antifungal potential against Candida albicans 25 . Some bacteria, such as Streptococcus pyogenes and S. mutans, showed greater susceptibility to propolis compared to metronidazole 30 .…”

Section: Characteristics Of the Articles Includedmentioning

confidence: 99%

“…(2021) 25 . Also, all studies had a low risk of bias to items "presence of control group" and "concentration of propolis".…”

Section: Assessment Of the Risk Of Biasmentioning

confidence: 99%

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Propolis controlled delivery systems for oral therapeutics in dental medicine: A systematic review

Barboza

Ribeiro

Ferreira

et al. 2022

Preprint

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This systematic review covers the existing evidence in the literature regarding the association of propolis with controlled delivery systems (DDS) and its potential therapeutic action in dental medicine. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Two independent reviewers performed a literature search up to 15th January 2022 in five databases: PubMed/Medline, Web of Science, Cochrane Library, Scopus, and Embase, to identify the eligible studies. Clinical, in situ, and in vitro studies that investigated the incorporation of propolis as the main agent in DDS for dental medicine were included in this study. Conversly, review articles, clinical cases, theses, dissertations, abstracts at congresses, and studies that had no application in dentistry were excluded. After examining carefully 55 full-text articles, 11 in vitro studies, 1 animal model, and 1 in vivo and in vitro study were included (n = 13). Relevant data were extracted from the included studies and analyzed qualitatively. The use of propolis has been reported in cariology, endodontics periodontics, and implantology. Propolis has shown non-cytotoxic, osteoinductive, antimicrobial, and anti-inflammatory properties. Moreover, propolis can readly be released from DDS for prolonged periods, having potential biocompatibility, safety, and potential advantage for applications in dental medicine.

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“…One of the main characteristics attributed to propolis in the literature is its antimicrobial action 13,15,25,29,30 . The oral environment is populated by a multi-species ecosystem.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Characteristics Of the Articles Includedmentioning

confidence: 99%

Section: Characteristics Of the Articles Includedmentioning

confidence: 99%

“…(2021) 25 . Also, all studies had a low risk of bias to items "presence of control group" and "concentration of propolis".…”

Section: Assessment Of the Risk Of Biasmentioning

confidence: 99%

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Propolis controlled delivery systems for oral therapeutics in dental medicine: A systematic review

Barboza

Ribeiro

Ferreira

et al. 2022

Preprint

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Synthesis and evaluation of antibacterial and antioxidant effects of propolis nanoparticles and cinnamon nanostructures in preventive dentistry: Experimental and theoretical approaches

Hamze,

Amiri,

Islami

et al. 2024

Phytochemical Analysis

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IntroductionNatural products such as green propolis and cinnamon have been used traditionally in medicine due to their medicinal value. Recently, interest has grown in developing nanotechnology‐based approaches to enhance the biological activity of these compounds.ObjectiveThis study evaluated the antioxidant and antibacterial properties of macro‐sized and nanostructured forms of green propolis and cinnamon against Streptococcus mutans (S. mutans) and the 2,2‐diphenyl‐2‐picrylhydrazyl (DPPH) assay.Material and MethodsThe sonochemical method was used to synthesize green propolis nanoparticles (PNPs) and cinnamon nanoparticles (CNPs). Their size was confirmed by scanning electron microscopy (SEM) and dynamic light scattering measurements, while they were compared with propolis (P) and cinnamon (C). The antioxidant activity was measured using the DPPH assay, while the minimum inhibitory concentration (MIC) test determined the antibacterial activity against S. mutans. One‐way analysis of variance (ANOVA) and Tukey's post hoc tests (α = 0.05) were conducted to analyze the data. Furthermore, docking calculations were carried out to examine the potential of incorporating any new supplements or therapies into your routine.ResultsThe MIC were 5.46, 21.87, 21.87, and 175 g/L for PNPs, P, CNPs, and C groups, respectively. The PNPs exhibited the most significant antibacterial effect while C was weakest. About antioxidant activity, PNPs and P exhibited significant differences from other groups (P = 0.000 and 0.001, respectively), while CNPs and C showed no significant difference between each other (P = 0.07). The docking calculations revealed a strong interaction between both nanoparticles and S. mutans. The binding energy of dihydroflavonols on propolis nanoparticles was −6.83 kcal/mol, indicating a stable connection.

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From propolis to nanopropolis: An exemplary journey and a paradigm shift of a resinous substance produced by bees

Javed

Mangla

Ahsan

2022

Phytotherapy Research

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Propolis, a natural resinous mixture produced by honey bees is poised with diverse biological activities. Owing to the presence of flavonoids, phenolic acids, terpenes, and sesquiterpenes, propolis has garnered versatile applications in pharmaceutical industry. The biopharmaceutical issues associated with propolis often beset its use as being too hydrophobic in nature; it is not absorbed in the body well. To combat the problem, various nanotechnological approaches for the development of novel drug delivery systems are generally applied to improve its bioavailability. This paradigm shift and transition of conventional propolis to nanopropolis are evident from the literature wherein a multitude of studies are available on nanopropolis with improved bioavailability profile. These approaches include preparation of gold nanoparticles, silver nanoparticles, magnetic nanoparticles, liposomes, liquid crystalline formulations, solid lipid nanoparticles, mesoporous silica nanoparticles, etc. Nanopropolis has further been explored to assess the potential benefits of propolis for the development of futuristic useful products such as sunscreens, creams, mouthwashes, toothpastes, and nutritional supplements with improved solubility, bioavailability, and penetration profiles. However, more high-quality clinical studies assessing the effects of propolis either alone or in combination with synthetic drugs as well as natural products are warranted and its safety needs to be firmly established.

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Antibacterial Activity of Propolis-Embedded Zeolite Nanocomposites for Implant Application

Cited by 13 publications

References 48 publications

Propolis controlled delivery systems for oral therapeutics in dental medicine: A systematic review

Propolis controlled delivery systems for oral therapeutics in dental medicine: A systematic review

Synthesis and evaluation of antibacterial and antioxidant effects of propolis nanoparticles and cinnamon nanostructures in preventive dentistry: Experimental and theoretical approaches

From propolis to nanopropolis: An exemplary journey and a paradigm shift of a resinous substance produced by bees

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