Antibacterial activity of plumbagin derivative-rich <i>Plumbago indica</i> root extracts and chemical stability

Kaewbumrung, Sermwut; Panichayupakaranant, Pharkphoom

doi:10.1080/14786419.2013.879585

Cited by 29 publications

(18 citation statements)

References 5 publications

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“…It's tuberous roots contains a quinoid constituent, plumbagin. Plumbagin is reported to have antibacterial, antifungal, anti-inflammatory and antiproliferative activities (Anuf et al 2014;Kaewbumrung and Panichayupakaranant 2014;Xue et al 2016). The plant is utilized in various Ayurvedic pharmaceutical formulations for treating cough, bronchitis, gastrointestinal disorders, skin disorders etc.…”

Section: Introductionmentioning

confidence: 99%

Calcium alginate encapsulated synthetic seed production in Plumbago rosea L. for germplasm exchange and distribution

Prakash

Nair

Alex

et al. 2018

Physiol Mol Biol Plants

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L. (Plumbaginaceae), is a medicinal shrub commercially exploited for its naphthoquinone principle, plumbagin, extracted from the roots especially for treating skin disorders. As the plant is exploited from the wild without being replenished, conservation of the species becomes inevitable. Synthetic seeds would provide for effective conservation, germplasm exchange and distribution of this species. A reliable protocol for synthetic seed production in has been developed encapsulating the axillary buds. The axillary buds from cultures established and multiplied using the nodal explants in Murashige and Skoog (MS) medium supplemented with Benzyl Adenine (BA) 1.5 mg/L and Indole 3-Acetic acid 1.0 mg/L, were used for synseed production. The plantlet conversion efficiency was the highest in synthetic seeds developed with sodium alginate 2.5% in modified MS with 0.4 M sucrose and CaCl 100 mM. This combination gave the earliest bud initiation (9.19 ± 0.39 days) and maximum number of shoots per explant (2.31 ± 0.16 shoots). Microshoots from the culture, when inoculated on to MS medium supplemented with Naphthalene Acetic Acid 1.0 mg/L gave the best rooting response with 10.67 ± 0.94 roots per plant and 5.42 ± 0.29 cm root length. This is the first report of synthetic seed production in using axillary buds as explant.

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Section: Introductionmentioning

confidence: 99%

Calcium alginate encapsulated synthetic seed production in Plumbago rosea L. for germplasm exchange and distribution

Prakash

Nair

Alex

et al. 2018

Physiol Mol Biol Plants

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“…The root contains the highest amount of plumbagin (0.17% w/w) among Plumbago species and is the part mostly contained in the medicinal remedies [ 10 ]. Plumbagin has been claimed for various biological activities, i.e., anthelmintic [ 4 , 9 , 11 ], antimalarial [ 12 ], antibacterial [ 6 ], antifungal [ 13 ], anti-inflammatory [ 14 , 15 ], immunosuppressive [ 16 ], abortifacient [ 8 ], anticancer [ 14 , 17 - 20 ], and antidiabetic activities [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Imbalance of the antioxidative system by plumbagin and Plumbago indica L. extract induces hepatotoxicity in mice

Sukkasem¹,

Chatuphonprasert²,

Tatiya-aphiradee³

et al. 2016

J Intercult Ethnopharmacol

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Background/Aim:Plumbago indica (PI) L. and its active constituent, plumbagin, has been traditionally claimed for several pharmacological activities; however, there is little information regarding their toxicity. The present study aims to examine the effects of plumbagin and PI extract (PI) on hepatic histomorphology and antioxidative system in mice.Materials and Methods:Adult male intelligent character recognition mice were intragastrically administered plumbagin (1, 5, and 15 mg/kg/day) or PI (20, 200, and 1,000 mg/kg/day) consecutively for 14 days. Hepatic histomorphology was examined. Plasma alanine transaminase (ALT) and aspartate transaminase (AST) levels, hepatic lipid peroxidation, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities, and the ratio of reduced to oxidized glutathione (GSH/GSSG) were determined.Results:Plumbagin and PI concentration-dependently induced hepatic injury based on histopathological changes via imbalance of antioxidative system. Plumbagin and PI significantly increased plasma ALT and AST levels, hepatic lipid peroxidation, and GPx activity but significantly decreased hepatic SOD and CAT activities. The GSH/GSSG ratio was significantly reduced by plumbagin.Conclusion:Plumbagin and PI caused hepatotoxic effects in the mice by unbalancing of the redox defense system. Therefore, plumbagin and PI-containing supplements should be used cautiously, especially when consumed in high quantities or for long periods.

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“…; Jeyachandran et al . ; Kaewbumrung and Panichayupakaranant ) including S. aureus . For instance, Nair et al .…”

Section: Resultsmentioning

confidence: 99%

“…The in vitro antibacterial activity of plumbagin is well known as several publications reported its activity against various bacterial organisms (Lajubutu et al 1995;de Paiva et al 2003;Jeyachandran et al 2009;Kaewbumrung and Panichayupakaranant 2014) including S. aureus. For instance, Nair et al (2016) described promising in vitro and ex vivo anti-staphylococcal activities of plumbagin.…”

Section: Mics Of Plumbaginmentioning

confidence: 99%

In vitroantibacterial activity of plumbagin isolated fromPlumbago zeylanicaL. against methicillin‐resistantStaphylococcus aureus

Periasamy

Iswarya

Pavithra

et al. 2019

Lett Appl Microbiol

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Plumbagin (5‐hydroxy‐2‐methyl‐1,4‐napthoquinone) is a bicyclic naphthoquinone, found in three major plant families viz. Plumbaginaceae, Ebenceae and Droseraceae. The phytochemical is reported to exhibit various pharmacological properties. In this study, plumbagin isolated from Plumbago zeylanica L. was investigated for its in vitro activity against methicillin‐resistant Staphylococcus aureus (MRSA). Against 100 MRSA isolates that included multi‐drug‐resistant phenotypes, plumbagin showed consistent activity with a narrow minimum inhibitory concentration (MIC) range of 4–8 μg ml−1. The time‐kill study revealed 99% kill of a reference MRSA strain, 8 h after exposure to plumbagin. In the combination MIC study using the reference MRSA strain, plumbagin showed synergistic effect with ciprofloxacin and piperacillin while additive or indifference effect with other commonly used antibiotics. The transmission electron micrograph of the reference MRSA strain treated with plumbagin confirmed cell wall and cytoplasmic changes. Our results demonstrated potent anti‐MRSA activity of plumbagin which was not impacted by multi‐drug resistance. This is a first ever study that evaluated in vitro anti‐MRSA activity of plumbagin employing large number of MRSA isolates. The findings of this study support the need for the further investigation on this phytochemical agent for therapeutic application. Significance and Impact of the Study This study revealed phytochemical plumbagin's potent and consistent in vitro antibacterial activity against clinically problematic methicillin‐resistant Staphylococcus aureus (MRSA) including multi‐drug‐resistant (MDR) phenotypes. The study results support further research to assess the clinical scope of plumbagin.

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Antibacterial activity of plumbagin derivative-rich Plumbago indica root extracts and chemical stability

Cited by 29 publications

References 5 publications

Calcium alginate encapsulated synthetic seed production in Plumbago rosea L. for germplasm exchange and distribution

Calcium alginate encapsulated synthetic seed production in Plumbago rosea L. for germplasm exchange and distribution

Imbalance of the antioxidative system by plumbagin and Plumbago indica L. extract induces hepatotoxicity in mice

In vitroantibacterial activity of plumbagin isolated fromPlumbago zeylanicaL. against methicillin‐resistantStaphylococcus aureus

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