Antibacterial activity of Physalis angulata L., Merremia umbellata L., and Cryptostegia grandiflora Roxb. Ex R.Br. - medicinal plants of the Colombian Northern Coast

Rivera, David E.; Ocampo, Yanet; Castro, Jenny; Caro, Daneiva; Franco, Luís

doi:10.1007/s13596-014-0176-0

Cited by 16 publications

(7 citation statements)

References 23 publications

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“…(Boraginaceae)Sauce sabaneroBronchitisBark, BudsOil Decoction, Infusion/OralWaizel-Bucay (2005) Croton malambo H.Karst.(Euphorbiaceae)CrotonRheumatismPainInflammationBarkInfusion/OralSalatino et al (2007)Suárez et al (2003) Cryptostegia grandiflora Roxb. ex R.Br.(Apocynaceae)Flor de muertoInflammationInfectionLeavesFresh plant in maceration/CataplasmCastro et al (2014)Rivera et al (2015) Dracontium dubium Kunth(Araceae)ChupaderaSnakebiteInflammationRootPoultice/TopicLévi-Strauss (1952) Maclura tinctoria (L.) D. Don. ex Steud.(Moraceae)PalomoraInflammationToothacheRheumatismBarkLatex Drops/TopicDecoction, /OralBeltrán Villanueva et al (2013) Merremia umbellata (L.) Hallier f.(Convolvulaceae)Juan de DiosInflammation and InfectionsAntiulcerRheumatismLeavesWhole PlantDecoction/OralCastro-Guerrero et al (2013)Rivera et al (2015) Physalis angulata L.(Solanaceae)Topo toropoInflammation and InfectionsAbdominal CrampsAsthma, Dermatitis, RheumatismCalycesAerial PartsWhole PlantPoultice/TopicInfusion/OralInfusion/OralRivera et al (2015)Soares et al (2003) Tabebuia rosea (Bertol.)…”

Section: Introductionmentioning

confidence: 99%

A screening of plants used in Colombian traditional medicine revealed the anti-inflammatory potential of Physalis angulata calyces

Rivera

Ocampo

Castro

et al. 2019

Saudi Journal of Biological Sciences

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The use of natural products by communities from the Colombian Caribbean region to treat health issues, together with biodiversity and geographical features, constitute a great scenery to develop new therapies based on ethnopharmacological heritage. Here, we investigated the anti-inflammatory potential of 10 commonly used plants in Colombian folk medicine, evaluating their effect on nitric oxide (NO) production by LPS-stimulated RAW 264.7 macrophages. The most active plant was evaluated in vivo using 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced mouse ear edema, along with its effect on the production of pro-inflammatory mediators in vitro. The extract of Physalis angulata L. calyces showed the highest activity. This extract was fractionated and its dichloromethane fraction (DF) was the most active in vitro, inhibiting the production of NO, prostaglandin E2 (PGE2), interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and monocyte chemotactic protein (MCP)-1 (CCL2). In vivo, DF showed a significant inhibition of ear edema and myeloperoxidase (MPO) activity, with evident reduction of the leukocyte infiltration into tissue. Our results support the ethnopharmacological use of the selected plants in folk medicine. P. angulata dichloromethane fraction represents a promising source of pharmacological compounds with great potential therapeutic use to treat inflammatory illness.

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Section: Introductionmentioning

confidence: 99%

A screening of plants used in Colombian traditional medicine revealed the anti-inflammatory potential of Physalis angulata calyces

Rivera

Ocampo

Castro

et al. 2019

Saudi Journal of Biological Sciences

Self Cite

View full text Add to dashboard Cite

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“…The observed antimicrobial activity of the T-M complex was ascribed to the capability of TGA-capped-CdTe QDs and M. emarginata extract phytochemical constituents (e.g., alkaloids, flavonoids, phenolics, saponins, steroids, and terpenoids) to induce oxidative stress on the bacteria (E. coli) surface biomolecules thereby damaging its membrane. Merremia umbellata methanol leaf extract (1000 µg mL −1 ) showed antibacterial activities with percentage inhibition of 32%, 55%, and 67% on Klebsiella pneumoniae (13883), S. aureus (25923), and Pseudomonas aeruginosa (27853), respectively [62]. The observed antibacterial effect was ascribed to phytochemicals such as leucoanthocyanidins, terpenes, and/or steroids and tannins present in the extract.…”

Section: Antimicrobial Activitiesmentioning

confidence: 99%

“…In Columbia, the leaves of M. umbellata prepared by maceration are used as an antibacterial, antifungal, and anti-inflammatory agent [62].…”

Section: Ethnomedicinal Uses Of Merremia Speciesmentioning

confidence: 99%

Research Progression of the Genus Merremia: A Comprehensive Review on the Nutritional Value, Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity

Olatunji

Adetunji

Olisah

et al. 2021

Plants

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The genus Merremia Dennst. ex Endl. (Convolvulaceae) is a rich source of structurally diverse phytochemicals with therapeutic relevance. This review presents the first comprehensive, up-to-date information and research progression on the nutritional value, ethnomedicinal uses, phytochemistry, pharmacological activities, and toxicity of the genus Merremia. Using the key search term “Merremia”, relevant documents and information were retrieved from electronic databases. Relevant documents were uploaded in RStudio with installed bibliometric software packages and used for data retrieval, tabulation, and network visualization. Bibliometric analysis revealed that ca. 55% of the studies related to Merremia were published in the last decade, which can be grouped into four thematic areas: (i) drug formulation, (ii) taxonomy, (iii) chemical analysis, and (iv) treatment of diseases. Ethnomedicinal uses, phytochemistry, and biological activities studies showed that species in the genus are promising medicinal plants with various pharmaceutical potentials. However, clinical studies to validate the efficacy of the reported bioactivities and the mechanisms underlying the various activities are lacking and should constitute a future research focus. Additionally, reports on the nutritional and antinutritional constituents of Merremia species revealed that the species meet high nutritional quality criteria for animals and are therefore suitable for inclusion in livestock diets. The few available investigations on toxicity indicated that most Merremia species are safe for human and animal use but not with prolonged chronic administration.

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“…Hasil penelitian sebelumnya menunjukkan bahwa ekstrak etanol 96% daun cecendet memiliki efek antimikroba terhadap bakteri Methicillin resistant S.aureus dan Pseudomonas aeruginosa secara in vitro. (Fitriani, 2011;Rivera, 2015). Seringkali masyarakat Indonesia menggunakan antibiotik bersamaan dengan penggunaan obat herbal.…”

Section: Pendahuluanunclassified

Pengaruh kombinasi ekstrak etanol herba cecendet (Physalis angulata l.) dengan beberapa antibiotik terhadap bakteri Staphylococcus aureus dan Klebsiella pneumonie

Choirunnisa

Sutjiatmo

2017

kjif

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The effect of a combination of ethanol extract of Physalis angulata L. with antibiotic against Staphylococcus aureus and Klebsiella pneumonie Abstract Infectious disease is one of the biggest health problems not only in Indonesia, but worldwide. Bacteria are important agents in causing infectious diseases. Indonesian people often use antibiotics along with herbal medicines. Cecendet (Physalis angulata L.) is one of the traditional plants that have antibacterial activity and widely used by the Indonesian community. This study aims to test the antibacterial activity of cecendet herbs and their effects when used in combination with various antibiotics. The preparation of P.angulata extract was carried out using reflux method with ethanol 50%. The characteristic examination and phytochemical screening are examined on simplicia and the extract. Determination of antibacterial activity from P.angulata extract was done by microdilution test method by assessing minimum inhibitory concentration (MIC). Determination of the effectiveness of combination of antibiotics with herbal cecendet against test microbes Staphylococcus aureus and Klebsiella pneumoniae was done by using checkerboard method. The results of phytochemical screening showed that simplicia and P.angulata extract contained alkaloids, flavonoids, saponins, polyphenols, monoterpenoids, sesquiterpenes, steroids and triterpenoids. The result of antibacterial activity test showed that P.angulata extract had antibacterial activity against S.aureus and K.pneumoniae with the MIC was 128 μg/mL, 256 μg/mL. The synergistic interaction of S.aureus is demonstrated by the combination of P.angulata herb extract with tetracycline. The additive/indifferent interaction of S.aureus is demonstrated by the combination of P.angulata extracts with ampicillin, and against K.pneumoniae shown by the combination of P.angulata extract of cecendet with ampicillin or tetracycline. Ethanol extract of P.angulata has antibacterial activity and and combination with antibiotics (ampicillin/tetracyclin) can give synergistic effect or additive of S.aureus and K.pneumoniae bacteria. Keywords: Cecendet, Physalis angulata L., MIC, antibiotic combination

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Antibacterial activity of Physalis angulata L., Merremia umbellata L., and Cryptostegia grandiflora Roxb. Ex R.Br. - medicinal plants of the Colombian Northern Coast

Cited by 16 publications

References 23 publications

A screening of plants used in Colombian traditional medicine revealed the anti-inflammatory potential of Physalis angulata calyces

A screening of plants used in Colombian traditional medicine revealed the anti-inflammatory potential of Physalis angulata calyces

Research Progression of the Genus Merremia: A Comprehensive Review on the Nutritional Value, Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity

Pengaruh kombinasi ekstrak etanol herba cecendet (Physalis angulata l.) dengan beberapa antibiotik terhadap bakteri Staphylococcus aureus dan Klebsiella pneumonie

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