Antibacterial activity of phenolic compounds and aromatic alcohols

Lucchini, Jean Jérôme; Corre, Jean-Philippe; Crémieux, A

doi:10.1016/0923-2508(90)90075-2

Cited by 124 publications

(78 citation statements)

References 22 publications

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“…Phenolic compounds and aromatic alcohols are reported to have antibacterial activity mediated by growth inhibition, lethal effect, and cytologic damage (Lucchini et al, 1990). The presence of phenolic hydroxyl groups in simvastatin and more hydroxyl groups in atorvastatin may correlate with their antibacterial activity.…”

Section: Resultsmentioning

confidence: 99%

Anin Vitro. Comparative Study on the Antioxidant Activity and Determination of Antibacterial Potential of Atorvastatin and Simvastatin

Ajith

Divya

2007

Pharmaceutical Biology

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Free radicals generated from oxidative stress (OS) have been depicted in the causation of cancerous and noncancerous diseases in humans. Increase in fat content of the body may favor the deleterious effect of free radical attack. The generation of free radicals is enhanced in respiratory burst during bacterial infection. The level of plasma membrane cholesterol appears to be critical in the regulation of microbial entry, intracellular trafficking, and exit. The current study was designed to compare the in vitro antibacterial and antioxidant activities of hypocholesterolemic drugs atorvastatin and simvastatin. Agar-well diffusion assay was used to screen the antibacterial activity using Gram-positive and Gram-negative bacterial strains. Antioxidant activity was evaluated using Fe 2þ -induced lipid peroxidation inhibiting activity in whole rat liver homogenate and Fe 3þ reducing activity using ferric-reducing antioxidant power (FRAP) assay. Atorvastatin and simvastatin inhibited the growth of all bacterial strains tested. The zone of inhibition produced by atorvastatin is higher than that of simvastatin. However, antioxidant activities of simvastatin were higher than those of atorvastatin. The exhibited pleiotropic activities of these statins suggest their clinical advantages against bacterial infection and oxidative stress-induced human ailments apart from their wide use for hypolipidemic effects.

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Section: Resultsmentioning

confidence: 99%

Anin Vitro. Comparative Study on the Antioxidant Activity and Determination of Antibacterial Potential of Atorvastatin and Simvastatin

Ajith

Divya

2007

Pharmaceutical Biology

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“…Kourˇil et al (1998) used 2-phenoxyethanol in concentrations of 0.5 ml/l for 2 min prior to artificial propagation of perch. However, 2-phenoxyethanol is used also as a preservative, with ability to lyse microbial cell membranes and erythrocytes (Lucchini et al 1990;Breslin et al 1991) and to block junction-mediated intercellular communication (Loch-Caruso et al 1984) and depressed complement activity and phagocytosis (Ortun˜o et al 2002). Administered in vitro, it induces apoptosis at low concentrations and necrosis at high concentrations (Anselmi et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Comparative effectiveness of 2-phenoxyethanol and Propiscin as anesthetics for juvenile sea bass Dicentrarchus labrax L.

2005

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The comparative effectiveness of 2-phenoxyethanol and Propiscin as anesthetics were studied on juvenile sea bass. Both anesthetics showed low toxicity and good hypnotic characteristics, however median survival times at the same concentration of both anesthetics differed. Propiscin showed much lower LT 50 than 2-phenoxyethanol, pointing towards its elevated toxicity in juvenile sea bass, even the same concentrations of Propiscin induced slower anesthesia than 2-phenoxyethanol. The most suitable Propiscin concentration for anesthesia was 0.56 ml/l, while the most suitable concentration of 2-phenoxyethanol was 0.32 ml/l for juvenile sea bass. Mortalities after 96 h were induced with Propiscin at lower concentrations then of 2-phenoxyethanol, resulting in the conclusion that the 2-phenoxyethanol is a safer anesthetic for use with juvenile sea bass (Dicentrarchus labrax L.).

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“…In höheren Konzentrationen wirkt 2-Phenoxyethanol auch gegen grampositive Bakterien wie Staphylococcus aureus sowie Pilze (Hall 1984). Der Mechanismus der antimikrobiellen Wirkung (u. a. Membranruptur, Änderung der Protonen-und Kaliumpermeabilität der Membran, Hemmung der Malatdehydrogenase, Hemmung der DNS-, RNS-und Proteinbiosynthese) ist gut untersucht (Fitzgerald et al 1992;Gilbert et al 1980;Hall 1984;Lucchini et al 1990). …”

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2‐Phenoxyethanol [MAK Value Documentation in German language, 1998]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 26. Lieferung, Ausgabe 1998 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme Metabolismus Verteilung und Ausscheidung Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstiges Bewertung

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Antibacterial activity of phenolic compounds and aromatic alcohols

Cited by 124 publications

References 22 publications

Anin Vitro. Comparative Study on the Antioxidant Activity and Determination of Antibacterial Potential of Atorvastatin and Simvastatin

Anin Vitro. Comparative Study on the Antioxidant Activity and Determination of Antibacterial Potential of Atorvastatin and Simvastatin

Comparative effectiveness of 2-phenoxyethanol and Propiscin as anesthetics for juvenile sea bass Dicentrarchus labrax L.

2‐Phenoxyethanol [MAK Value Documentation in German language, 1998]

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