Antibacterial activity of phenethyl alcohol and resulting membrane alterations

Membrane damage of bacteria by silanols treatment

“…The cytoplasmic membrane lost its integrity and showed disordered structures when compared to the control, which shows a smooth and intact membrane. Unlike the result from the phenethyl alcohol treatment on S. aureus (Corre et al 1990) the enlargement of the cell wall of the Grampositive bacteria are not noticeable for the triethylsilanol treated bacteria. Cross wall formation was observed in the Gram-positive bacteria, indicative of cell division.…”

“…A general observation of E. coli treated by triethylsilanol was that the cytoplasmic membrane (CM) appeared to be retracted from the outer membrane (OM) and disorganized whereas the control showed an intact cell envelope between the outer membrane and the cytoplasmic membrane as shown in Figure 1. Corre et al (1990) reported that membrane alteration of E. coli, P. aeruginosa, and S. aureus occurred with a phenethyl alcohol treatment. These authors claimed that the Gram-negative cell envelops were permeabilized and the plasmic membrane in S. aureus was solubilized with phenethyl alcohol treatment.…”

“…coli was reported as well as enlargement of the cell wall of S. aureus upon phenethyl alcohol treatment (Corre et al 1990). In the Gram-positive bacteria, E. faecalis and S. aureus, the cytoplasmic membrane disruptions are clearly visible as seen in Figure 2 and Figure 3 respectively.…”

PROFILING OF ANTI-FUNGAL ACTIVITY OF Trichoderma virens 159C INVOLVED IN BIOCONTROL ASSAY OF Ganoderma boninense

“…Band 5 of the hexane extract of T. virens 7b (Angel et al, 2016) and fraction 2 of the EtOAc extract of T. virens 159c efficiently suppressed the growth of G. boninense PER 71 probably due to the presence of PEA in both fractions. PEA showed strong inhibition against mycelial growth of fungal pathogens (Rouissi et al, 2013) and the anti-bacterial activity of PEA was also reported previously (Corre et al, 1990). However, there were three compounds in common namely PEA, 3, 4-dimethylpent-2-en-1-ol and dodecanoic acid were compounds identified in the highly inhibitory fractions of extracts of both endophytic Trichoderma, namely the hexane extract of T. virens 7b (band 5) and the EtOAc extract of T. virens 159c (fraction 2).…”

In vitro investigation of the antimicrobial activity of a series of lipophilic phenols and naphthols

“…2 It is generally accepted that phenols and benzyl alcohols exert antimicrobial action [3][4][5][6] on the non-specific ability to alter membranes in Gram-negative bacteria. [7][8][9][10] On the other hand, a more specific mode of action of phenolic compounds has been suggested, especially against Gram-positive bacteria, since the bactericidal concentrations are not dependent on the type of cell wall.…”