Antibacterial Activity of Pd(II) Complexes with Salicylaldehyde-Amino Acids Schiff Bases Ligands

Abstract

Key words salicylaldehyde-amino acid Schiff base; Pd(II) complex; antibacterial activity As bacterial drug resistance to currently administered treatments is increasing, the need for the development of new therapeutic strategies against bacterial infection becomes more stringent. Therefore, there is an urgent demand for the development of new antimicrobial agents with improved properties such as enhanced activity, reduced toxicity and shortened duration of therapy.

Spectral characterization, optical band gap calculations and DNA binding of some binuclear Schiff-base metal complexes derived from 2-amino-ethanoic acid and acetylacetone

“…The majority of work of amino acids Schiff-bases has been carried out on the aromatic aldehyde (salicylaldehyde) and its derivatives [13,14].…”

Promising Antimicrobial Activity of an Oxime Based Palladium(II) Complex

“…Patients suffering from critical diseases like AIDS, ailing people taking immunosuppressive drugs for cancer treatment or people who have undergone organ transplantation are easily prone to fungal infections. In the last few years, the increasing drug resistance of bacterial and fungal species and the infections caused by them have posed a serious threat to mankind. In this context, metal based drugs are the optimum choice as they might be more bio‐specific yet less hazardous to the host.…”

“…Palladium(II) complexes generated from such type of bidentate N,O‐donor ligands serve as potential catalysts in C–C bond‐forming reactions . Of late, a Schiff‐base palladium(II) complex generated from ortho ‐hydroxyl substituted aromatic aldehyde has been shown to possess remarkable antibacterial activity . Curiously, the bioactivities of oxime based Schiff‐base palladium(II) complexes having such type of aromatic moieties in N‐ and O‐donor environment are very rare indeed .…”

Chelating Competency and Electrochemical Response of a Heterocyclic Phenylhydrazone and its Copper Chelate

“…Such molecules and their metal chelates are having wide variety of applications in the pharmaceutical, catalysis, analytical and corrosion field [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] . In the present investigation we explored the structure of the 3-acetylpyridine phenylhydrazone and its copper chelate using various spectroscopic methods.…”