Antibacterial activity of organomontmorillonites and organovermiculites prepared using chlorhexidine diacetate

Holešová, Sylva; Samlíková, Magda; Pazdziora, Erich; Valášková, Marta

doi:10.1016/j.clay.2013.07.013

Cited by 28 publications

(11 citation statements)

References 21 publications

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“…The unmodified clay pastes (Kp and Tp) have developed a total aerobic microbial count >3 × 10 3 cfu/g five days after their preparation ( Table 7 ). Jou et al (2016) [ 63 ] and Holesova et al (2013) [ 69 ] also reported that natural clay minerals (e.g. kaolinite), showed no antibacterial effect.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Antimicrobial Protection of Pharmaceutical Kaolin and Talc Modified with Copper and Zinc

et al. 2021

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Six pharmaceutical pastes were prepared using chemically modified kaolin and talc powders. Tests were conducted to determine their structural and chemical characteristics as well as their antimicrobial protection, thus rendering them suitable for cosmetic and pharmaceutical uses. Kaolin and talc were treated chemically via the cation exchange method to load the clay particles with copper and zinc ions, two cations well known for their antimicrobial properties. Mineralogical analyses were conducted by using X-ray diffraction (XRD) before and after the modification, confirming the mineralogical purity of the samples. Scanning electron microscopy was also used in conjunction with energy dispersed spectroscopy (SEM-EDS) to obtain chemical mapping images, revealing the dispersion of the added metals upon the clay minerals surfaces. Moreover, chemical analysis has been performed (XRF) to validate the enrichment of the clays with each metal utilizing the cation exchange capacity. All modified samples showed the expected elevated concentration in copper or zinc in comparison to their unmodified versions. From the X-ray photoelectron spectroscopy (XPS), the chemical state of the samples’ surfaces was investigated, revealing the presence of salt compounds and indicating the oxidation state of adsorbed metals. Finally, the resistance of pastes in microbial growth when challenged with bacteria, molds, and yeasts was assessed. The evaluation is based on the European Pharmacopeia (EP) criteria.

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Section: Resultsmentioning

confidence: 99%

Evaluation of the Antimicrobial Protection of Pharmaceutical Kaolin and Talc Modified with Copper and Zinc

et al. 2021

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“…This obviously warrants further research. This argument becomes more intense because many researchers have used organoclays that were prepared from specific organic molecules as a potential antimicrobial agent (Holešová et al, 2013). Therefore, although the synthetic surfactants can elevate the bioavailability of organic contaminants to a level congenial for clay modulated biodegradation, the molecules themselves may become potentially toxic to the degrading microorganisms.…”

Section: Application Of Surfactants and Their Toxicity To Microorganimentioning

confidence: 99%

Bioremediation of PAHs and VOCs: Advances in clay mineral–microbial interaction

Biswas

Sarkar

Rusmin

et al. 2015

Environment International

122

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“…5 In this regard, montmorillonite (MMT) could perhaps be considered to be the clay most used as a drug-delivery carrier and it has been used for the preparation of antibacterial materials. 6 Among the antibacterial agents intercalated into MMT are chlorhexidine acetate, 5,7–9 cetylpyridinium chloride, 10 ciprofloxacin, 11 and tetracycline. 12…”

Section: Introductionmentioning

confidence: 99%

“…Vermiculite 8 and kaolinite 13 are also other phyllosilicate minerals that have been modified with chlorhexidine acetate, in order to prepare antibacterial materials; however, to our knowledge, there has been no published reports on the antibacterial properties of modified palygorskite (PLG). The only references regarding last topic are those published by Chang et al.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial properties and release kinetics of chlorhexidine diacetate from montmorillonite and palygorskite clays

et al. 2019

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Organoclays were prepared by means of cation-exchange reactions using different concentrations of chlorhexidine diacetate and two different types of clays: montmorillonite and palygorskite. The antibacterial activity against Escherichia coli was evaluated by means of disk diffusion tests as well as through bacterial growth inhibition (monitored by optical density measurements) in Luria broth media. Results indicate that modified palygorskites showed a greater antibacterial activity than those exhibited by modified montmorillonite, as latter only displayed antibacterial properties at the highest chlorhexidine diacetate loading. Modeling of chlorhexidine release was also performed and the models best described the drug release phenomena depended on the type of clay; being the Higuchi model and Korsemeyer–Peppas model for montmorillonite, whereas the zero-order model and Korsemeyer–Peppas model for palygorskite.

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Antibacterial activity of organomontmorillonites and organovermiculites prepared using chlorhexidine diacetate

Cited by 28 publications

References 21 publications

Evaluation of the Antimicrobial Protection of Pharmaceutical Kaolin and Talc Modified with Copper and Zinc

Evaluation of the Antimicrobial Protection of Pharmaceutical Kaolin and Talc Modified with Copper and Zinc

Bioremediation of PAHs and VOCs: Advances in clay mineral–microbial interaction

Antibacterial properties and release kinetics of chlorhexidine diacetate from montmorillonite and palygorskite clays

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