Antibacterial Activity of Ordered Gold Nanorod Arrays

Zhu, Yuejing; Ramasamy, Mohankandhasamy; Yi, Dong Kee

doi:10.1021/am503153v

Cited by 66 publications

(45 citation statements)

References 45 publications

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“…73 Therefore, fabrication of gold nanorods (AuNRs) where manipulation of size, dimension, and aspect ratio is possible is imperative in the advancement of applications such as drug delivery and water treatment. Zhu et al 74 prepared two-and three-dimensional uniform arrays of AuNRs by confined convective arraying techniques and studied the photoheated bacterial effects on E. coli. The resulting AuNRs had an aspect ratio of ~2.5.…”

Section: Nanorodsmentioning

confidence: 99%

Antibacterial properties and toxicity from metallic nanomaterials

Vimbela¹,

Ngo²,

Fraze³

et al. 2017

IJN

504

334

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The era of antibiotic resistance is a cause of increasing concern as bacteria continue to develop adaptive countermeasures against current antibiotics at an alarming rate. In recent years, studies have reported nanoparticles as a promising alternative to antibacterial reagents because of their exhibited antibacterial activity in several biomedical applications, including drug and gene delivery, tissue engineering, and imaging. Moreover, nanomaterial research has led to reports of a possible relationship between the morphological characteristics of a nanomaterial and the magnitude of its delivered toxicity. However, conventional synthesis of nanoparticles requires harsh chemicals and costly energy consumption. Additionally, the exact relationship between toxicity and morphology of nanomaterials has not been well established. Here, we review the recent advancements in synthesis techniques for silver, gold, copper, titanium, zinc oxide, and magnesium oxide nanomaterials and composites, with a focus on the toxicity exhibited by nanomaterials of multidimensions. This article highlights the benefits of selecting each material or metal-based composite for certain applications while also addressing possible setbacks and the toxic effects of the nanomaterials on the environment.

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Section: Nanorodsmentioning

confidence: 99%

Antibacterial properties and toxicity from metallic nanomaterials

Vimbela¹,

Ngo²,

Fraze³

et al. 2017

IJN

504

334

View full text Add to dashboard Cite

show abstract

“…Gram-positive, Gram-negative, and mixed species of bacteria were inactivated thermally by exposing gold [218] or graphene NPs [219] to NIR. The temperature of NP-bacterial suspensions was found to be increased beyond the physiological limits of bacteria [220]. …”

Section: Nanotechnology Based Strategies For Biofilm Control and Tmentioning

confidence: 99%

Recent Nanotechnology Approaches for Prevention and Treatment of Biofilm-Associated Infections on Medical Devices

Ramasamy

Lee

2016

BioMed Research International

Self Cite

216

126

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Bacterial colonization in the form of biofilms on surfaces causes persistent infections and is an issue of considerable concern to healthcare providers. There is an urgent need for novel antimicrobial or antibiofilm surfaces and biomedical devices that provide protection against biofilm formation and planktonic pathogens, including antibiotic resistant strains. In this context, recent developments in the material science and engineering fields and steady progress in the nanotechnology field have created opportunities to design new biomaterials and surfaces with anti-infective, antifouling, bactericidal, and antibiofilm properties. Here we review a number of the recently developed nanotechnology-based biomaterials and explain underlying strategies used to make antibiofilm surfaces.

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“…25 Initially, the seed solution was prepared by mixing 250 μL of 0.01 M HAuCl 4 with 7.5 mL of 0.1 M CTAB and 600 μL of ice-cold 0.01 M NaBH 4 under vigorous stirring at room temperature. The growth solution was prepared by adding 400 μL of 0.01 M HAuCl 4 , 64 μL of 0.1 M ascorbic acid and 35.6 μL of 0.1 M AgNO 3 to 9.5 mL of 0.1 M CTAB.…”

Section: Preparation Of Aunrsmentioning

confidence: 99%

Lipid-coated gold nanocomposites for enhanced cancer therapy

An¹,

Kang²,

Ko³

2015

IJN

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The aim of the work reported here was to develop lipid-coated multifunctional nanocomposites composed of drugs and nanoparticles for use in cancer therapy. We incorporated thermosensitive phospholipids onto the surface of anisotropic gold nanoparticles (AuNPs) to further enhance drug delivery, with possible additional applications for in vivo imaging and photothermal cancer therapy. Lipid-coated nanohybrids loaded with the drug docetaxel (DTX) were prepared by a thin-film formation, hydration, and sonication method. Nanoparticles and their composites were characterized using particle-size analysis, zeta potential measurements, transmission electron microscopy, UV-visible spectroscopy, and reverse-phase high-performance liquid chromatography, demonstrating successful loading of DTX into the lipid bilayer on the surface of the gold nanoparticles. Initial in vitro studies using breast-cancer (MCF-7) and melanoma (B16F10) cell lines demonstrated that the drug-containing nanocomposites at equivalent drug concentrations caused significant cytotoxicity compared to free DTX. Differential flow cytometry analysis confirmed the improved cellular uptake of lipid-coated nanocomposites. Our preliminary results show that DTX-loaded anionic lipid-coated gold nanorod (AL_AuNR_DTX) and cationic lipid-coated gold nanoparticle (CL_AuNP_DTX) possess effective tumor cell-suppression abilities and can therefore be considered promising chemotherapeutic agents. Further evaluation of the therapeutic efficacy of these hybrid nanoparticles combined with external near-infrared photothermal treatment is warranted to assess their synergistic anticancer actions and potential bioimaging applications.

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Antibacterial Activity of Ordered Gold Nanorod Arrays

Cited by 66 publications

References 45 publications

Antibacterial properties and toxicity from metallic nanomaterials

Antibacterial properties and toxicity from metallic nanomaterials

Recent Nanotechnology Approaches for Prevention and Treatment of Biofilm-Associated Infections on Medical Devices

Lipid-coated gold nanocomposites for enhanced cancer therapy

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